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Muzamil Saleem

1st Year Ph.D Student
Bayer School of Natural and Environmental Sciences
Biological Sciences

Pollock Lab, Mellon Hall
Phone: x4856

Education:

M.Sc. Neuroscience, King's College, London, 2009
B.Sc. Clinical Sciences, King's College, London, 2004
Bio

Muzamil is a first year PhD student in the Department of Biological Sciences at Duquesne University, Pittsburgh. Muzamil received a B.Sc. in Clinical Sciences from King's College, London and a M.Sc. in Neuroscience from the Institute of Psychiatry, King's College, London, where his work focused on translational Alzheimer's disease research. He continued his research upon graduating, and accepted a research investigator position at the Institute of Psychiatry in the laboratory of Professor Simon Lovestone. This culminated in him co-authoring three peer-reviewed publications. In order to gain further experience in neurodegeneration research, Muzamil accepted a Predoctoral Fellowship at the University of Pittsburgh. He worked on projects researching the cellular and molecular mechanisms of neurodegeneration, by the use of genetically modified mouse models. The work sought to explore the role of lipid associated genes in the pathogenesis of Alzheimer's Disease and yielded two co-authored peer-reviewed publications. He is a member of the Pollock laboratory in the Department of Biological Sciences, where he will complete his thesis research. 

In his free time, Muzamil actively engages his passion of photography, enjoys live music and, on occasion, writes. He is involved in the Graduate Student Organization of the Biological Sciences, where he the Media Coordinator. Muzamil's duties include: designing and maintaining the organization's Facebook page and web site, media production - including designing logos, t-shirts, fliers and welcome packets for new graduate students - as well as serving as a photographer.

Research

The Pollock laboratory's research directions include the analysis of TRP (calcium channels), as well as analyzing the immune response; both in the context of a rat chronic pain model. The laboratory collaborates with Dr. Jelena Janjc (Mylan School of Pharmacy) who has developed a novel dual-labeled nanoemulsion , which allows for the visualization of neuroinflammation by near infrared (NIR) and 19F MRI, using small animal live imaging to co-localize the immune system response to chronic pain and changes in TRP expression. 

Publications

Cronican AA, Fitz NF, Carter A, Saleem M, Shiva S, Barchowsky A, Koldamova R, Schug J, Lefterov I. Genome-wide alteration of histone H3K9 acetylation pattern in mouse offspring prenatally exposed to arsenic. PLoS One. 2013;8(2):e53478. doi: 10.1371/journal.pone.0053478. Epub 2013 Feb 6. PubMed PMID: 23405071; PubMed Central PMCID: PMC3566160.

Fitz NF, Cronican AA, Saleem M, Fauq AH, Chapman R, Lefterov I, Koldamova R. Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice. J Neurosci. 2012 Sep 19;32(38):13125-36. PubMed PMID: 22993429; PubMed Central PMCID: PMC3646580.

Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Coppola G, Geschwind D, Simmons A, Lovestone S, Dobson R, Hodges A; AddNeuroMed Consortium. Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood. J Alzheimers Dis. 2012;30(3):685-710. doi: 10.3233/JAD-2012-111592. PubMed PMID: 22466004.

Thambisetty M, An Y, Kinsey A, Koka D, Saleem M, Güntert A, Kraut M, Ferrucci L, Davatzikos C, Lovestone S, Resnick SM. Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment. Neuroimage. 2012 Jan 2;59(1):212-7. doi: 10.1016/j.neuroimage.2011.07.056. Epub 2011 Jul 28. PubMed PMID: 21824521; PubMed Central PMCID: PMC3425349.

Güntert A, Campbell J, Saleem M, O'Brien DP, Thompson AJ, Byers HL, Ward MA, Lovestone S. Plasma gelsolin is decreased and correlates with rate of decline in Alzheimer's disease. J Alzheimers Dis. 2010;21(2):585-96. doi: 10.3233/JAD-2010-100279. PubMed PMID: 20571216.