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Peter L.D. Wildfong, B.Sc., Ph.D.

Associate Professor
Pharmacy
Pharmaceutical Sciences

Mellon Hall 422C
Phone: 412.396.1543

Education:

Ph.D. Industrial and Physical Pharmacy Purdue University
Grad, Cert. Materials Engineering Purdue University
Dip, Pharm, R&D Toronto Institute of Pharmaceutical Technology
Hons. B.Sc. Biochemistry, McMaster University
Bio

Peter Wildfong is an Associate Professor of Pharmaceutics, and has been on the faculty at Duquesne University since 2004. He received an Hons. B.Sc. (1998) in Biochemistry from McMaster University and a Ph.D. (2004) in Industrial and Physical Pharmacy, with a graduate certificate in Materials Engineering (2004) from Purdue University.  His research focus is heavily oriented towards pharmaceutical materials science, where current projects seek to better understand how specific physico-chemical and structural properties of pharmaceutically relevant materials impact both large-scale manufacturing and final dosage form performance.

Research

Ongoing research is centered on 1) developing materials informatics models that will allow prediction of mechanically activated solid state phase transformations of APIs and excipients, through the investigation of mitigating factors in high-shear induction of polymorphism and disordering; 2) solubilization of poorly water soluble API through preparation of binary amorphous solid dispersions, as well as predictions regarding the formation and stability of these materials.  In support of these topics, the lab also works to advance the use of solid state characterization techniques including powder X-ray diffractometry, calorimetry, microscopy, and thermogravimitry.

Scholarship

Grants/Contracts – 2006 to present

$283,257 PI: Peter L.D. Wildfong; Co-PI: Ira S. Buckner. AbbVie, Inc. "Modeling and Prediction of Solid Dispersion Formulation using Molecular Descriptors." July 15, 2013 - July 15, 2016.

$85,413    PI: Peter L.D. Wildfong; Co-PI: Ira S. Buckner.  National Institute for Pharmaceutical Technology & Education/Food and Drug Administration. “Physical Characterization of Complex Mixtures: Solid Dispersion API:Polymer Miscibility Determination.” September 1, 2012 – August 31, 2013.

$6,511    PI: Jane E. Cavanaugh; Co-PI: Ira S. Buckner, Peter L.D. Wildfong. Duquesne University Hunkele Dreaded Disease Award. “Solid Particulate Intranasal Administration of L-Dopa for Direct to CNS Delivery.” May 11, 2012 – June 30, 2014.

$8,000 PI: James K. Drennen; Co-PIs: Carl A. Anderson, Ira S. Buckner, Peter L.D. Wildfong. Nycomed Inc. Contract. “Semisolids Manufacturing Training Course.” Dec 2010 – Jan 2011.

$7,145    PI: Peter L.D. Wildfong.  Duquesne University Faculty Development Fund Award.  “Materials Informatics and Multivariate Statistical Phenomenological Screening: Prediction of Binary Amorphous Solid Dispersion Potential.” May 1, 2009 – June 30, 2011.           

$651,811 ($55,415 Duquesne) PI: Lee E. Kirsch (University of Iowa) Subcontract ($7,600): Peter L.D. Wildfong. Food & Drug Administration/NIPTE Teaching Contract. “Reviewer Education in State of the Art Pharmaceutical Manufacturing.” Sep 2009 – Nov 2011.

$50,000  PI:  James K. Drennen; Co-PI: Carl A. Anderson, Ira S. Buckner, Peter L.D. Wildfong. Bristol-Myers-Squibb Industrial Research Contract.  “Chemical imaging of bilayer tablets.” May 2009 – April 2010.

$24,177  PI:  Peter L.D. Wildfong. Food & Drug Administration Teaching Contract.  “Solid Oral Dosage Form Unit Operations Reviewer Training.”  May 12, 2009 – Dec 19, 2010.

$1,198,000 ($164,857 Duquesne) PI: James K. Drennen; Co-PI: Peter L.D. Wildfong, Carl A. Anderson, Ira S. Buckner.  Food & Drug Administration/National Institute for Pharmaceutical Technology and Education Research Contract.  “Development of quality by design guidance elements on design space specifications across scales with stability considerations.”  September 1, 2008 – Aug 31, 2010.           

$10,000  PI: James K. Drennen; Co-PI: Moji C. Adeyeye, Carl A. Anderson, Wilson S. Meng, Peter L.D. Wildfong. National Science Foundation, I/UCRC planning grant. “Collaborative Research:  Center for Pharmaceutical Manufacturing and Formulation.” August 15, 2008 – July 31, 2009.              (no-cost extension granted through end of 2009)

$35,440  PI:  Peter L.D. Wildfong; Co-PI: Kenneth R. Morris (Purdue University). Food & Drug Administration Teaching Contract.  “Solid Oral Dosage Form Unit Operations Reviewer Training.”  October 1, 2006 – September 30, 2007, (no-cost extension granted through March 31, 2008)

$2,879    PI: Peter L.D. Wildfong; Co-PIs: Christopher K. Surratt, Wilson S. Meng, Shane P. Desselle.  Duquesne University Academic Learning Outcomes Assessment Mini-Grant.  “Evaluation of a Pilot Advanced Mentorship Program for Undergraduate Pharmacy Students.”  May 2006 – April 2007.

$169,900  PI:  Jennifer A. Aitken (Chemistry); Co-PIs:  Peter L.D. Wildfong and Stephanie J. Wetzel (Forensic Sciences). National Science Foundation, Course Curriculum Laboratory Improvement, Adaptation and Implementation (CCLI A&I).  “Development of Hands-On Powder X-Ray Diffraction laboratory Modules for Use in Chemistry, Forensic Science and Pharmacy Curricula.”  August 1, 2005 – July 31, 2008.     

$9,931    PI: Peter L.D. Wildfong.  Duquesne University Faculty Development Fund Award.  “Solid-State Mechanical Amorphization Potential of Crystalline Drug Compounds.” March 2005 – January 2007.

 

Publications – 2006 to Present

 

Michael D. Moore and Peter L.D. Wildfong, “Informatics Calibration of a Molecular Descriptors Database to Predict Solid Dispersion Potential of Small Molecule Organic Solids,” Int. J. Pharm., 418: 217-226, 2011.
Bruno C. Hancock, Kenneth R. Morris, Peter L.D. Wildfong, “Editorial: A Priori Performance Predictions in Pharmaceutical Sciences,” Int. J. Pharm., 418: 149-150, 2011.

Christopher K. Surratt, Khalid M. Kamal, Peter L.D. Wildfong, “Research funding expectations as a function of faculty teaching/administrative load,” Res. Soc. Admin. Pharm., 7: 192-201, 2011.

Autumn L. Stewart, Ira S. Buckner, Peter L.D. Wildfong, “Horizontal Integration of a Pharmaceutics and Pharmacy Practice Course using a Novel Shared Assessment,” Am. J. Pharm. Ed., 75(3): Article 44, 2011.
Michael D. Moore, Zhenqi Shi, Peter L.D. Wildfong, “Structural Interpretation in Composite Systems Using Powder X-ray Diffraction: Applications of Error Propagation to the Pair Distribution Function,” Pharm. Res., 27(12): 2624-2632, 2010.
Yannan Lin, Zhenqi Shi, Peter L.D. Wildfong, “Thermal conductivity measurements for small molecule organic solid materials using modulated differential scanning calorimetry (MDSC) and data corrections for sample porosity,” J. Pharm. Biomed. Anal., 51: 979-984, 2010.
Michael D. Moore, Alison M. Steinbach, Ira S. Buckner, Peter L.D. Wildfong, “A Structural Investigation into the Compaction Behavior of Pharmaceutical Composites using Powder X-Ray Diffraction and Total Scattering Analysis,” Pharm. Res., 26(11): 2429-2437, 2009.

Peter L.D. Wildfong, “Effects of Pharmaceutical Processing on the Solid Form of Drug and Excipient Materials,” in Polymorphism in Pharmaceutical Solids, 2nd Ed., Harry G. Brittain, Ed.: Informa Healthcare, Inc., pp. 511-560, 2009.

Yannan Lin, Robert P. Cogdill, Peter L.D. Wildfong, “Informatic Calibration of a Materials Properties Database for Predictive Assessment of Mechanically Activated Disordering Potential for Small Molecule Organic Solids,” J. Pharm. Sci., 98(8): 2696-2708, 2009.

Michael D. Moore, Peter L.D. Wildfong, “Aqueous Solubility Enhancement through Engineering of Binary Solid Composites: Pharmaceutical Applications,” J. Pharm. Innov., 4(1): 36-49, 2009.

Michael D. Moore, Robert P. Cogdill, Peter L.D. Wildfong, “Evaluation of Chemometric Algorithms in Quantitative X-ray Powder Diffraction (XRPD) of Intact Multi-Component Consolidated Samples,” J. Pharm. Biomed. Anal., 49(3): 619-626, 2009.

Steven M. Short, Robert P. Cogdill, Peter L.D. Wildfong, James K. Drennen III, Carl A. Anderson, “A Near-Infrared Spectroscopic Investigation of Relative Density and Crushing Strength in a Four-Component Solid Dosage System,” J. Pharm. Sci., 98(3): 1095-1109, 2009.

Michael D. Moore, Prashi Jain, Patrick T. Flaherty, Peter L.D. Wildfong, “1-Isopropyl-4-nitro-6-methoxy-1H-benzimidazole,” Acta Cryst. E64: o1336-o1337, 2008.

Michael D. Moore, Robert P. Cogdill, Steven M. Short, Colleen R. Hair, Peter L.D. Wildfong, “The use of net analyte signal orthogonalization in the separation of multi-component diffraction patterns obtained from X-ray powder diffraction of intact compacts,” J. Pharm. Biomed. Anal., 47(2): 238-247, 2008.

Peter L.D. Wildfong, Kenneth R. Morris, Carl A. Anderson, Steven M. Short, “Demonstration of a Shear-Based Solid-State Phase Transformation in a Small Molecular Organic System: Chlorpropamide,” J. Pharm. Sci., 96(5): 1100-1113, 2007.

Peter L.D. Wildfong, Kenneth R. Morris, Bruno C. Hancock, Michael D. Moore, “Towards an understanding of the Structurally Based Potential for Mechanically Activated Disordering of Small Molecule Organic Crystals,” J. Pharm. Sci.  95(12): 2645-2656, 2006.

 

Presentations – 2006 to Present

Peter L.D. Wildfong, "Characterization of Drug-Polymer Composite Materials: Evaluation of Drug Dispersability in polyvinylpyrrolidone:vinyl acetate copolymer (PVPva) and polyethylene glycol (PEG 4000)." Invited Speaker, 23rd Midwest Organic Solid State Chemistry Symposium, Lexington, KY, June 13-15, 2013.

Colleen R. Hair, Jeremy Pappacena, Peter L.D. Wildfong, “Investigation of a model for prediction of disordering potential of small molecule organic crystalline solids based on molar volume and glass transition temperature,” American Association of Pharmaceutical Scientists National Exposition, Chicago, IL, October 14-18, 2012.

Dipy M. Vasa, Peter L.D. Wildfong, “Investigation of Different Milling Techniques on the Physical Characteristics of Binary Composite Mixtures of Ribavirin and Poloxamer 188,” American Association of Pharmaceutical Scientists National Exposition, Chicago, IL, October 14-18, 2012.

Peter L.D. Wildfong, “Structural characterization of solid composite materials as a tool for drug product formulation and development.”  Invited Speaker, PPXRD-11, Fort Myers, FL, May 15-18, 2012.

Peter L.D. Wildfong, “Amorphous Solids: Predicting the Good, the Bad, and the Vitrified.” Invited Seminar, Duquesne University Bayer School of Natural and Environmental Sciences, Pittsburgh, PA, January 13th, 2012.

Peter L.D. Wildfong, Robert P. Cogdill, Yannan Lin, “A Comparison of Fundamental and Empirical Models for Predicting Disordering Potential of Small Molecule Organic Crystals,” American Association of Pharmaceutical Scientists National Exposition, Washington, DC, October 23-27, 2011.

Carmen Popescu, Michael D. Moore, L. Zhou, H. Almoasen, R. Zhu, Peter L.D. Wildfong, D. Damour, X. Parissaux, P. Lefevre, “Orally Disintegrating Films (ODF) as Vectors for Micro/Nanoparticle Delivery Using Benzocaine as a Model Drug,” Controlled Release Society Annual Meeting and Exposition, National Harbor, MD, July 30 – August 3, 2011.

Peter L.D. Wildfong, “Applications of Informatics Calibrated Databases to Model Complex Physical Behavior in Pharmaceutical Materials,” Invited Speaker, Dr. David J.W. Grant Symposium on Solid-State Pharmaceutics, Minneapolis, MN, June 3, 2010.

Michael D. Moore and Peter L.D. Wildfong, “Informatics Calibration of a Molecular Descriptor Database in Predicting Amorphous Molecular Solid Dispersion Potential of Small Molecule Organic Solids.” American Association of Pharmaceutical Scientists National Exposition, New Orleans, LA, November 14-18, 2010.

Peter L.D. Wildfong, and Michael D. Moore, “Application of the Atomic Pair Distribution Function Transform in Studying Process-related Changes to Crystallographic Order in Intact Composites” Invited Speaker, Bristol-Myers-Squibb Co., New Brunswick, NJ, December 10, 2009.

Michael D. Moore and Peter L.D. Wildfong, “A Structural Investigation of into the Compaction Behavior of Pharmaceutical Composites using Powder X-Ray Diffraction and Total Scattering Analysis.”  American Association of Pharmaceutical Scientists National Exposition, Los Angeles, CA, November 8-12, 2009.

Peter L.D. Wildfong, “Impact of Raw Materials Properties on Dosage Form Manufacture and Performance,” Invited Speaker, FDA Short Course: Solid Oral Dosage Form Review Training, Silver Spring, MD, September 22nd, 2009.

Peter L.D. Wildfong,Characterization Techniques for Intrinsic Properties of the Drug Substance and Excipients,” Invited Speaker, 51st Annual International Industrial Pharmaceutical Research and Development Conference, Merrimac, WI, June 1-5, 2009.

Peter L.D. Wildfong and Robert P. Cogdill, “Integrating Process Analytical Technology (PAT) with Drug Development: Advantages and Tactics,” Invited Speaker, 4th Annual IQPC Conference on Patenting and Polymorphism, Frankfurt, Germany, May 29th, 2008.

Peter L.D. Wildfong, and Robert P. Cogdill, “The Scientific Basis for Process Understanding,” Invited Speaker, FDA Short Course: Modern Process Development for Pharmaceutical Manufacturing: Approaches for QbD/PAT Systems Development and Implementation, Silver Spring, MD, March 4th, 2008.

Peter L.D. Wildfong, Michael D. Moore, Robert P. Cogdill, “Advances in Quantitative PXRD: Improving Resolution for Multi-Component Systems using Contemporary Chemometric Methods,” Invited Speaker, PPXRD-7, Orlando, FL, February 25-28, 2008.

Yannan Lin, Colleen R. Hair, Peter L.D. Wildfong, “Zero-Porosity Extrapolations for Measurements of Thermal Conductivity in Small Molecule Organic Solid Materials using Modulated DSC.”  American Association of Pharmaceutical Scientists National Exposition, Atlanta, GA, November 16-20, 2008.

Michael D. Moore, Colleen R. Hair, Peter L.D. Wildfong, “Comparison of Multivariate Quantitative PXRD Applications in Intact, Quaternary Pharmaceutical Compacts Containing both Crystalline and Disordered Components.” American Association of Pharmaceutical Scientists National Exposition, Atlanta, GA, November 16-20, 2008.

Michael D. Moore and Peter L.D. Wildfong, “Application of Pair Distribution Function (PDF) in Structural Analysis of Intact Multi-Component Consolidated Compacts.” American Association of Pharmaceutical Scientists National Exposition, Atlanta, GA, November 16-20, 2008.

Michael D. Moore, Robert P. Cogdill, Steven M. Short, Colleen R. Hair, Peter L.D. Wildfong, “The use of net analyte signal orthogonalization in the separation of multi-component diffraction patterns obtained from X-ray powder diffraction of intact compacts,” 57th Annual Conference on Applications of X-ray Analysis: Denver X-ray Conference, Denver, CO, August 4-8, 2008.

Michael D. Moore, Colleen R. Hair, Peter L.D. Wildfong, “Chemometric Applications in Quantitative X-ray powder Diffraction of Intact Consolidated Samples,” 57th Annual Conference on Applications of X-ray Analysis: Denver X-ray Conference, Denver, CO, August 4-8, 2008.

Michael D. Moore, Colleen R. Hair, Robert P. Cogdill, Peter L.D. Wildfong, “Chemometrics as a Tool for Comparing Different Geometrical Modes in Multi-Component Quantitative X-Ray Powder Diffraction Analysis of Intact Compacts,” PPXRD-7, Orlando, FL, February 25-28, 2008.

Lauren A. Pantzar, Michael D. Moore, Colleen R. Hair, Peter L.D. Wildfong, “Quantitative Multivariate Applications in PXRD of Intact Multi-Component Consolidated Pharmaceutical Systems,” PPXRD-7, Orlando, FL, February 25-28, 2008.

Carl A. Anderson and Peter L.D. Wildfong, “Drying Processes in the PAT Era,” Invited Speaker, FDA Short Course: Solid Oral Dosage Form Review Training, Silver Spring, MD, May 14th, 2007.

Michael D. Moore, Colleen R. Hair, Robert P. Cogdill, Peter L.D. Wildfong, “Chemometrics as a Tool for Comparing Different Geometrical Modes in Multi-Component Quantitative X-Ray Powder Diffraction Analysis of Intact Compacts,” American Association of Pharmaceutical Scientists National Exposition, San Diego, CA, November 11-15, 2007.

Peter L.D. Wildfong, “Mechanical Amorphization: A Structurally-based Model for Predicting Disordering of Small Molecule Organic Crystals,” Invited Seminar, University of Connecticut Graduate School of Pharmaceutical Sciences, Storrs, CT, March 20th, 2007.

 

Yannan Lin, Marc Rizzo, Peter L.D. Wildfong, “Mechanically Activated Disordering Model for Small Molecular Organic Crystals,” Parenteral Drug Association Graduate Student Symposium, Anaheim, CA, April 25th, 2006.

Courses

PHCE 360 Pharmaceutical Principles and Drug Delivery Systems I

PHCE 361 Pharmaceutical Principles and Drug Delivery Systems II

GPSC 518 Fundamentals of Pharmaceutical Solids

GPSC 503 Pharmaceutical Unit Operations and Formulation

GPSC 619 Adv. Pharmaceutics: Drug Delivery Systems

GPSC 691 Graduate Seminar (Pharmaceutics)

CHEM 598 Characterization of Solid Materials

Honors & Awards

2013 PYI Professor of the Year Award. Awarded by the Class of 2016 on behalf of the Mylan School of Pharmacy.

2011 Duquesne University Creative Teaching Award.  Awarded by the Duquesne University Center for Teaching Excellence for design and implementation of novel integrated assessments between the Clinical Sciences and Basic Sciences, within the Mylan School of Pharmacy (jointly awarded to collaborators Autumn Stewart, Ira Buckner, Peter Wildfong).

2010 Omicron Delta Kappa Teacher of the Year Award.  Awarded by the ODK National Honors Society on behalf of Duquesne undergraduate student body.

2010 PYI Professor of the Year Award.  Awarded by the PYI Class on behalf of the Mylan School of Pharmacy.

2008 Dean’s Award (Mylan School of Pharmacy). Presented for demonstrated excellence in enhancement of student learning and advisement (presented at annual faculty retreat, Oglebay, WV, May 20, 2008).

2006 Outstanding Manuscript Award in Analysis and Pharmaceutical Quality.  American Association of Pharmaceutical Scientists, (presented at AAPS national meeting, San Antonio, TX, October 29th, 2006).