Sanket Anaokar3rd Year Ph.D Student
Bayer School of Natural and Environmental Sciences
Patton-Vogt Lab, Mellon Hall
Characterization of a novel pathway for phosphatidylcholine biosynthesis in Saccharomyces cerevisiae
Glycerophosphopholipids (phospholipids) are essential components of biological membranes. Several metabolic diseases like diabetes, cancer and obesity can cause increased or decreased levels of certain phospholipids in cellular membranes. Thus, the maintenance of membrane composition is crucial to cell functioning. Phosphatidylcholine (PC) is the major phospholipid found in all eukaryotic membranes. The two main pathways by which PC is synthesized are the methylation pathway and the Kennedy pathway (CDP-DAG pathway). Here we report on the identification of a novel pathway for PC biosynthesis in S. cerevisiae.