Division of Pharmaceutical Sciences
Faculty
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Jelena Janjic, Ph.D.Assistant Professor of Pharmaceutics 415 Mellon |
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Educational Background
2009 Research Biologist, Carnegie Mellon University, Pittsburgh, PA, USA
Project: 19F MRI reagent development C synthesis, formulation and biological testing
Advisor: Prof. Eric T. Ahrens
2006 Postdoctoral Research Associate, Scripps Florida, Jupiter, Florida, USA
Project: Highthroughput screening cell based assay development Advisor: Dr. Kendall Nettles
2005 Ph.D. (Pharmaceutical Sciences), University of Pittsburgh, Pittsburgh, PA, USA
Thesis advisors: Prof. Billy W. Day and Prof. Peter Wipf
Thesis Title: Design, Synthesis and Biological Evaluation of New Agents Targeting Estrogen Receptor-Alpha and CBeta
1998 PharmD eq. (Diplomirani Farmaceut), Belgrade University, form S.R. Yugoslavia
Thesis advisor: Prof. Dusan Malesev
Thesis Title: Application of IR Spectroscopy in Drug Analysis
Research Interests
Design, synthesis, formulation and biological testing of multifunctional nanoreagents with focus on molecular imaging and drug delivery. Fluorine chemistry applied to design and synthesis of theranostics. Rational design of drug delivery vehicles for DNA, RNA, and small molecules in cancer and inflammation disease models. Studying inflammation and breast cancer using modern imaging techniques (NIR and 19F MRI) in vitro and in vivo. Studying effects of cancer therapeutics on the immune system. Role of inflammation in acute and chronic pain.
Current Grant Support
2011-2013 Pennsylvania State Health Formula Research Grants Program (C.U.R.E. Award) From Insoluble Perfluorocarbon Oils to Multifunctional Nanoparticles for Breast Cancer Imaging and Treatment.
Role: Principal Investigator
2011-2014 1R15AI081218-01A2 Non-viral Genetic Modification of Antigen-presenting Cells in Allografts, Role: Co-Investigator (PI: Dr. Wilson Meng).
2010-2012 Faculty Development Funds Award from Duquesne University
Title: Perfluorocarbon nanoemulsions for simultaneous delivery of COX2 inhibitor and antiproliferative agent to breast tumors Role: Principal Investigator
Funding History
2009-2010 1R41EB009618 - 01A1 Title: Dual Mode Nanoemulsions for 19F MRI and Fluorescence Detection Role: Principal Investigator
2008-2013 5P41EB001977-22 NMR Center Grant A MULTIDISCIPLINARY NMR CENTER FOR BIOMEDICAL RESEARCH Program Director Chen Ho, Carnegie Mellon University; Project TRD3 Cell Labeling Chemistry to Make In-vivo MRI a Practical Method Project Leader: Alan S. Waggoner, PhD, Carnegie Mellon University
Role: Investigator (2008-2009)
2006-2007 1R21NS056998-01 Assay Development for Identification of ER-NFkB Pathway Selective Agents PI: K. Nettles, PhD, Scripps Florida
Role: Research Associate
2004-2005 BC030739 Design, Synthesis and Biological Evaluation of Focused Combinatorial Libraries of Antiestrogens ($90,000) DOD Breast Cancer Predoctoral Fellowship
Role: Principal Investigator
Honors and Awards
2004 Graduate Student Excellence Award, School of Pharmacy, Univ. of Pittsburgh, Pittsburgh, PA 2001
Jewish Health Care Foundation - CORO Health Sciences Fellowship, Pittsburgh, PA
Publications and Patents
1.Hitchens,T.K.; Ye, Q.; Eytan, D.F.; Janjic, J.M.; Ahrens,E.T.; Ho, C. 19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells Magnetic Resonance in Medicine, 2011, 65, 1144-1153
2.Kadayakkara, D.K.K.; Janjic, J.M.; Pusateri, L.K.; Young, W.B.; Ahrens, E.T. In vivo observation of intracellular oximetry in perfluorocarbon-labeled glioma cells and chemotherapeutic response in the CNS using fluorine-19 MRI Magnetic Resonance in Medicine 2010, 64,1252-1259
3.Helfer, B.; Balducci, A.; Nelson, A.; Janjic, J.M.; Gil, R.R.; Kalinski, P.; M. de Vries, J.; Ahrens, E.T.; Mailliard, R. Functional assessment of human dendritic cells labeled for in vivo 19F MRI cell tracking Cytotherapy. 2010, 12, 238-250.
4.Kadayakkara, D.K.K.; Beatty, P; Janjic, J.M.; Turner, M.; Ahrens, E.; Finn, O. Inflammation driven overexpression of the hypoglycosylated abnormal MUC1 links inflammatory bowel disease (IBD) and pancreatitis Pancreas 2010, 39, 510-515
5.Srinivas, M.; Turner, MS; Janjic, J.M.; Morel, P.A.; Laidlaw, D.H.; Ahrens, E.T. In vivo cytometry of antigen specific T-cells using 19F MRI Magnetic Resonance in Medicine 2009, 62, 747-753
Peer-reviewed research publications (2002-2008)
6. Sarachine, M.J.; Janjic, J.M.; Wipf, P; Day, B.W. Biphenyl C-cyclopropylalkylamides as new scaffolds for targeting estrogen receptor Molecular Pharmacology, Bioorganic Medicinal Chemistry Letters 2009, 19, 2404-2408.
7. Janjic, J.M.; Srinivas, M.; Kadayakkara, D.K.K.; Ahrens, E.T. Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection, Journal of American Chemical Society 2008, 130, 2832-2413. (Cited 38 times)
8. Poloyac, S.M.; Rohan, L.C.; Janjic, J.M.; Gibbs, R.B.; Kroboth, P.D.; Smith, R.B.; GEAR-UP (Graduate Education And Research at the University of Pittsburgh) A Program for Educating Students about Pharmaceutical Research, American Journal of Pharmaceutical Education 2005, 69, 91-97.
9. Wipf, P.; Coleman, C.M.; Janjic, J.M.; Iyer, P.S.; Fodor, M.D.; Shafer, Y. A. Stephenson, C.R. J.; Kendall, C.; Day, B.W. Microwave-Assisted Libraries from Libraries Approach toward the Synthesis of Allyl- and C-Cyclopropylalkylamides, J. Comb. Chem., 2005, 7, 322-330.
10. Janjic, J.M.; Mu, Y. ; Kendall, C.; Stephenson, C.R. J.; Balachandran, R.; Raccor, B. S. ; Lu, Y.; Zhu, G.; Xie, W.; Wipf, P.; Day, B. W. New Antiestrogens from a Library Screen of Homoallylic Amides, Allylic Amides and C-Cyclopropylalkylamides, Bioorganic and Medicinal Chemistry 2005, 13, 157-164.
11. Wipf, P.; Janjic, J.M.; Stephenson, C.R. Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation-transmetalation-aldimine addition sequence, Organic and Biomolecular Chemistry 2004, 2, 443-445.
12. Lu, G.; Janjic, B.M.; Janjic, J.; Whiteside, T.L.; Storkus, W.J.; Vujanovic, N.L. Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1), -beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand, Journal of Immunology 2002, 168, 1831-1839.
Reviews
13. Janjic, J.M.; Ahrens, E.T. Fluorine-containing nanospheres for MRI Advanced Reviews, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, September/October 2009, 1, 492-501
14. Wipf, P.; Gong, H.; Janjic, J.M.; Li, S.; Day, B.W.; Xie, W. New Opportunities for pregnane X receptor (PXR) targeting in drug development. Lessons from enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues Mini Reviews Medicinal Chemistry 2007, 7, 617-625
Patents
15. Janjic, J.M., Ahrens, E.T. Fluoropolymer compositions and methods for producing cellular labels for nuclear magnetic resonance techniques PCT Int. Appl. 2009, WO 2009009105 A2 20090115
16. Ahrens, E.T.; Janjic, J.M. Emulsions containing perfluoro ethers for NMR techniques and other applications; PCT Int. Appl. 2009, WO 2009134435
National and International Scientific Meetings
Oral Presentations
1. Janjic, J.M. Road to True Theranostic Nanoreagents is Paved with Perfluorocarbons Symposium in Honor of Donald J. Burton: Fluorine Chemistry the Iowa Way, American Chemical Society 242nd National Meeting, Denver, CO, Aug. 29 C Sept. 1 2011
2. Janjic, J.M.; Kadayakkara, D.K.K.; Hitchens, K.T.; Ahrens, E.T. Multispectral 19F MRI Reagents C Design, Synthesis and Biological Evaluation Fluorine Chemistry Symposia, American Chemical Society 236th National Meeting Aug. 17-21 Philadelphia 2008
3. Janjic, J.M.; Srinivas, M.; Kadayakkara, D.K.K.; Ahrens, E.T. Synthesis of novel dual-mode self-delivering nanoparticles for in vivo fluorine-19 MRI and fluorescence cell tracking¡ Joint Molecular Imaging Conference, Providence, RI, Sep. 8-11, 2007
Invited Lectures
4. Janjic, J.M. From Inert Perfluorocarbons to Theranostic Agents: A road less travelled
Invited lecture at The Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia (EU), March 3rd, 2011
Poster Presentations
5. Patel, S.K., OHanlon, C.E., Janjic, J.M. Perfluorinated Lipids for Drug Delivery Winter Fluorine Conference St. Peters Beach, FL, Jan. 9-14 2011 1st PRIZE WINNER for BEST POSTER
6. OHanlon, C.E.; Amede, K.; Kadayakkara, D.K.K.; Ahrens, E.T.; Janjic, J.M. Self-assembling perfluorocarbon nanoemulsions for drug delivery and imaging¡± American Association of Pharmaceutical Scientists (AAPS) National Biotechnology Conference May San Francisco, CA May 16-18, 2011
7. Janjic, J.M., OHanlon, C.E., Tunney, R. PFC Based, MR Detectable Nanoemulsions for Celocoxib Delivery to Breast Tumors CHI World Pharmaceutical Congress, Philadelphia, PA, June 16-17,2010
8. Patel, S.K., Jaswal,S., Kadayakkara, D.K.K., OHanlon, C.E., Ahrens, E.T., Janjic, J.M. "Fluorinated Nanoemulsions and Liposomes for Drug Delivery: Design, Synthesis and Formulation" Pharmaceutics Graduate Student Research Meeting (PGSRM) in Columbus, Ohio 17-19 June, 2010,
9. Janjic, J.M.; Patrick, M.J.; Schmidt, B.F.; Mailliard, R.; Waggoner, A.S.; Ahrens, E.T. Multimodal fluorine containing nanoemulsions with biosensing properties World Molecular Imaging Congress, Montreal, Canada, Sept. 23-26, 2009, poster
10. Helfer, B.M.; Nelson, A.D.; Janjic, J.M.; Ahrens, E.T.; Gil, R.R.; Kalinski, P.; de Vries, J.; Milliard, R.B. Using a 19F MRI tracer agent for in vivo tracking of human dendritic cell vaccines International Society for Magnetic Resonance in Medicine International Meeting (ISMRM) 17th Scientific Meeting & Exhibition Honolulu, Hawai'i, USA 18-24 April 2009, oral
11. Hitchens, T.K.; Ye, Q.; Eytan, D.F.; Wu, Y.L.; Janjic, J.M.; Ahrens, E.T.; Ho, C. Comparison of Iron-oxide and perfluorocarbon based cellular contrast agents for detecting immune cell infiltration in models of organ transplant rejection¡± International Society for Magnetic Resonance in Medicine International Meeting (ISMRM) 17th Scientific Meeting & Exhibition Honolulu, Hawai'i, USA 18-24 April 2009, poster
12. Janjic, J.M.; Kadayakkara, D.K.K.; Pusateri, L.K.; Ahrens, E.T. Novel perfluorocarbon nanoemulsions for 19F MRI cell trackgin of two cell populations in vivo International Society for Magnetic Resonance in Medicine International Meeting (ISMRM) 17th Scientific Meeting & Exhibition Honolulu, Hawai'i, USA 18-24 April 2009, e-poster
13. Saranchine, M.; Janjic, J.M.; Coleman, C.; Wipf, P.; Day, B.W. Biphenyl C-Cyclopropylkylamides as New Scaffolds for Targeting Estrogen Receptor Beta 31st National Medicinal Chemistry Symposium, American Chemical Society, June 15-18th, Pittsburgh, PA, 2008, poster
14. Srinivas, M.; Turner, M. S.; Morel, P. A.; Janjic, J. M.; Laidlaw, D. H.; Ahrens, E. T. Longitudinal tracking and quantification of T cells using in vivo 19F MRI International Society for Magnetic Resonance in Medicine International Meeting (ISMRM) 16th Scientific Meeting & Exhibition, Toronto, Canada, May 3-9 2008, oral presentation C 4th best abstract
15. Kadayakkara, D. K.; Pusateri, L. K.; Xu, H.; Janjic, J. M.; Ahrens, E.T. In vivo intracellular pO2 measurements of perfluorocarbon labeled 9L glioma cells International Society for Magnetic Resonance in Medicine International Meeting (ISMRM) 16th Scientific Meeting & Exhibition, Toronto, Canada, May 3-9 2008, oral presentation
16. Hitchens, T. K.; Ye, Q.; Zhang, H.; Foley, L. M.; Janjic, J. M.; Ahrens, E. T.; Ho, C. 19F MRI Detection of Acute Cardiac Allograft Rejection with In Situ Perfluorocarbon Labeling of Immune Cells International Society for Magnetic Resonance in Medicine International Meeting (ISMRM) 16th Scientific Meeting & Exhibition, Toronto, Canada, May 3-9 2008, poster
17. Janjic, J.M.; Saranchine, M.; Coleman, C.; Wipf, P.; Day, B.W. New Ligands for Estrogen Receptors, American Chemical Society National Meeting, Washington DC, 2005, poster
18. Janjic, J.M.; Wipf, P.; Day, B.; New Antiestrogens from Libraries of Homoallylic amides, Allylic amides and C-Cyclopropylalkylamides, Era of Hope, Philadelphia, PA, 2005, poster
19. Janjic, J.M.; Coleman, C.; Wipf, P.; Day, B.W.; Targeting Agents for ER¦Á and ER: Fluorescence Polarization Based Screening, CHI High-Content Analysis, San Francisco CA, 2005, poster
20. Janjic, J.M.; Coleman, C.; Kendall, C.; Stephenson, C.R. J.; Mu, Y.; Xie, W.; Day, B.W.; Wipf, P.; New Antiestrogens from Library Screens of Homoallylic Amides, Allylic Amides and C-Cyclopropylalkylamides National Medicinal Chemistry Symposium, Madison WI, 2004, poster
