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David W. Seybert, Ph.D.

Professor
Bayer School of Natural and Environmental Sciences
Chemistry and Biochemistry

313 Mellon Hall
Phone: 412.396.6465

Education:

Ph.D., Biochemistry, Cornell University, 1976
B.A., Chemistry and Biology, Bloomsburg State College, 1972
Bio

David W. Seybert is a Professor of Chemistry and Biochemistry at Duquesne University.  He earned a B.A. degree from Bloomsburg State College in 1972 and a Ph.D. in Biochemistry from Cornell University in 1976. Following the completion of a three-year postdoctoral research appointment at Duke University Medical Center, Dr. Seybert joined the faculty of Duquesne University in 1979.  Over the years, Dr. Seybert’s research interests have extended from mechanistic studies of mammalian enzymes that catalyze biological oxidations to the role of lipid peroxidation in human disease and aging.  He was appointed as Interim Dean of the Bayer School in 2000 and Dean in 2002. At Duquesne, he has served as Chair of the Organizing Committee for the 2003 conference “Stem Cell Research:  Science, Ethics and Religion” and as co Chair of the 2008 Rachel Carson Legacy Conference “Green Chemistry: Solutions for a Healthy Economy.” Dr. Seybert has also served as a member of the Board of Directors of Bishop Canevin High School and currently serves on the STEM Advisory Board of the Carnegie Science Center.  

Research

Our research interests focus on the general theme of biological oxidations and oxidative stress, with particular interest in defining mechanisms by which lipid peroxidation byproducts result in structural and functional modification of proteins and other biomolecules.  Research in the laboratory ranges from model in vitro systems to studies that correlate antioxidant status and lipid peroxidation biomarkers in humans.  We also have an ongoing interest in the study of the cytochrome P-450 dependent steroid hydroxylases and the protein-protein interactions essential for steroidogenic electron transport among flavoproteins, iron-sulfur proteins, and heme proteins in these systems.

Publications

Evanseck, J.D., Gawalt, E.S., Huisso, A., Madura, J.D., Nunes, S.S., Oki, R.R., Seybert, D.W., and Venkatraman, R., Optimizing Research Productivity While Maintaining Educational Excellence: A Collaborative Endeavor, in Broadening Participation in Undergraduate Research (Boyd, M.K. and Wesemann, J.L., eds.) Council on Undergraduate Research, 65-76 (2009)

Seybert, D.W., Evanseck, J.D., and Doctor, J.S., Integrated Biological and Chemical Laboratory Experiences for Enhanced Education, Research Opportunities, and Career Development. CUR Quarterly, 26(3), 104-108 (2006)

Seybert, D.W., A two-semester integrated chemistry laboratory experience at Duquesne University. Division of Chemical Education, Abstract 1295, 213st ACS National Meeting (2006)

Pollock, A.M., and Seybert, D.W., Modification of human serum albumin induced by E-2-hexenal and 4-hydroxy-2-nonenal. Free Radical Biol. Med. 35, S109 (2003)

Seybert, David W., Development of a Preparing Future Faculty module at Duquesne University. Abstract 425, Sixteenth Biennial Conference on Chemical Education, (2000)

Professional Affiliations
  • American Association for the Advancement of Science
  • American Chemical Society
  • American Society for Biochemistry and Molecular Biology
  • Society for Free Radical Biology and Medicine
  • Sigma Xi
  • Spectroscopy Society of Pittsburgh
  • Council of Environmental Deans and Directors (CEDD/NCSE)
  • Phi Kappa Phi