Aleem Gangjee, Ph.D.

Division of Pharmaceutical Sciences

Faculty

aleem-gangjee

Aleem Gangjee, Ph.D.

Professor of Medicinal Chemistry
Mylan School of Pharmacy Distinguished Professor
Endowed Chair - Adrian Van Kaam

451 Mellon
T 412.396.6070
gangjee@duq.edu

Educational Background

B. S. (Chemistry)--Indian Institute of Technology
M.S. (Organic Chemistry),--Indian Institute of Technology
Ph.D.--(Medicinal Chemistry)--University of Iowa
PostDoctoral, Biochemistry--University of Iowa
NCI Postdoctoral Trainee, Medicinal Chemistry--SUNY at Buffalo

Courses Taught

Undergraduate Courses Taught: (1979 to present)

232 Basic Pharmacology (University of Pittsburgh, 1983)
309 Biochemistry and Nutrition
310 Analysis of Drug Substances
313 Medicinal Chemistry & Natural Products
314 Medicinal Chemistry & Natural Products
352 Foundations of Pharmacology and Medicinal Chemistry
421 Medicinal Chemistry
427 Biomedical Sciences/Therapeutics VI: Pulmonary, Oncology and Hematology Module
429 Biomedical Sciences and Therapeutics VIII

Graduate Courses Taught (1979 to present)

522 Spectral Methods
523 Advanced Medicinal Chemistry I
524 Advanced Medicinal Chemistry II
623 Selected Topics in Medicinal Chemistry
671 Chemistry of Heterocyclic Compounds
527 Advanced Medicinal Chemistry

Research

Synthetic Medicinal Chemistry
Computer Assisted Drug Design
Design and Synthesis of Antitumor Agents Related to Folates and Folate Metabolism
Design and Synthesis of Multi-Acting Antitumor Agents
Design and Synthesis of Novel Tubulin Antimitotic Inhibitors
Design and Synthesis of Mono, dual and Multi-Tyrosine Kinase Inhibitors
Heterocyclic Synthesis of Novel Ring Systems
Stereochemistry of Inhibition of Folate Metabolizing Enzymes
Stereochemistry of attachment of purinergic agents to receptors
Design of combination chemotherapeutic potential in single agents

Research in Progress

Structure-base design and synthesis of:
Antibacterial and Antitumor Agents Related to Antifolates.
Receptor Tyrosine Kinase Inhibitors as Antitumor Agents.
Dual Thymidylate Synthase/Dihydrofolate Reductase Inhibitors.
Dual and Multi-acting Inhibitors as Antitumor Agents.
Single Agents with Cytotoxic and Cytostatic Activities
Tubulin Inhibitors as Antitumor Agents.
Computer Assisted Drug Design.

Honors and Awards

Ranked first in the graduating M.S. Class of 1971, Organic Chemistry, Indian Institute of Technology.
International Student Scholarship, University of Iowa, 1971-75.
Research Assistantship, Graduate College, University of Iowa, 1971-75.
Award for Outstanding Academic Achievement Graduate College, University of Iowa, 1973.
Phi Lambda Upsilon, Chemistry Honor Society, 1975.
Postdoctoral Trainee Fellowship National Cancer Institute training grant at SUNY, Buffalo, 1976-1979.
The American Men and Women of Science, 1979.
Rho Chi, Pharmacy Honor Society, 1980.
The Society of Sigma XI, 1981.
Starter Grant, Faculty Research and Scholarship Award, Duquesne University, April 1982.
The New York Academy of Science, 1982.
President, Duquesne Sigma Xi Club, 1983.
Runner-up Duquesne Man of the Year, 1985-86.
Commencement Speaker, Pharmacy Class of 1988.
Duquesne University Presidential Award for Faculty Excellence in Scholarship, 1988.
School of Pharmacy Teacher of the Year Award, 1988.
Shannon Award, NIH, 1991.
Who's Who in American Education, 1992.
National Institutes of Health (NIH) consultant.
Duquesne University School of Pharmacy Award for Excellence in Research, 1995.
Who's Who in Medicine and Healthcare, 1996.
Elected to the American Association for Cancer Research, 1996.
National Institutes of Health, BNP-1 Special Emphasis Pane Study Sectionl, 1996.
Duquesne University School of Pharmacy Award for Excellence in Teaching, 1997.
The only faculty in the School of Pharmacy to receive both the awards for Excellence in Teaching and Research.
Duquesne University Presidential Award for Faculty Excellence in Teaching, 1997.
One of three faculty at Duquesne University to receive both the University Presidential Award for Faculty Excellence in Scholarship and Teaching.
Among the top three authors to publish the most number of papers in The Journal of Medicinal Chemistry for 1995 and two years in a row, 1997 and 1998, of all authors both nationally and internationally.
Awarded twenty US patents.
World Health Organization invited participant in collaborative research, 1998.
Granted the title of Mylan School of Pharmacy Distinguished Professor, 1998.
NIH National Cancer Institute Study Section Experimental Therapeutics I, 1999-2003.
Chosen as a N.C.P.A. Member's Favorite Professor, 2000.
Editorial Advisory Board Member, Current Medicinal Chemistry, Anti-Cancer Agents, 2001-present.
Ad-Hoc Member: National Institutes of Health, Center for Scientific Review, AIDS and Related Research, 2002-2003.
Ad-Hoc Member: National Institutes of Health, Center for Scientific Review, AIDS and AIDS Related Research Integrated Review Group (AARR), AIDS and AIDS Related Research Study Section, 2003-2004.
Ad-Hoc Member: National Institutes of Health, Center for Scientific Review, Oncologic Sciences Integrated Review Group, Drug Discovery & Molecular Pharmacology (DMP) Study Section, 2003-2004.
Editorial Board of Medicinal Chemistry Reviews - Online, 2004-2006.
Member of The Honor Society of Phi Kappa Phi, 2007.
Recipient of the President’s Award for Faculty Excellence in Scholarship, September 2008.
Member: Editorial Advisory Board, Journal of Medicinal Chemistry, 2008-2012.
Received the President's Award for Faculty Excellence in Scholarship, Sept. 2008.
Adrian Van Kaam, C.S.Sp., Endowed Chair in Scholarly Excellence, 2010-2015.
Chairperson: National Institutes of Health, Center for Scientific Review Special Emphasis Panel, ZRG1 OTC-K (04) Cancer Therapeutics Study Section; Feb. 17, 2011.

Recent Grants

Single Agents With Designed Combination Chemotherapy Potential National Institutes of Health, National Cancer Institute (NIH/NCI) American Recovery and Reinvestment Act of 2009 Two years: June 1, 2009 to May 31, 2011
Antitumor Antimitotics That Reverse Tumor Resistance NIH, National Cancer Institute (NCI) Five years: Feb. 24, 2006 -- Jan. 31, 2011
Novel, P. jirovecii Specific Antipneumocystis Agents NIH, National Institute of Allergy and Infectious Diseases (NIAID) five years: May 15, 2006 to Apr. 30, 2011
Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
NIH, National Cancer Institute Five years: Sept. 26, 2006 to July 31, 2011
Discovery of Novel PCFT-Targeted Agents. National Institutes of Health, National Cancer Institute (NCI). March 1, 2011 to Feb. 28, 2016. Co-Principal Investigator. Co-PI: Dr. Larry Matherly, (* contact PI, Wayne State Univ. )Total award $2,296,601
DU award $955,370 (funded at 83%).
Water Soluble Antimitotics That Circumvent Tumor Resistance. National Institutes of Health, National Cancer Institute (NCI). June 1, 2011 to March 31, 2016. Co-Principal Investigator (*contact PI). Co-PI: Dr. Susan Mooberry (University of Texas Health Science Center at San Antonio). Total award: $1,567,135, DU award: $842,615 (funded at 83%).
Duquesne University Five year appointment: 2010 - 2015. Adrian Van Kaam, C.S.Sp. Endowed Chair for Scholarly Excellence.Awarded: $15,000 / per year ($75,000 total).
Pneumocystis jirovecii Targeted Antiopportunistic Agents. National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIAID), 02/01/2012 - 01/31/2017. Principal Investigator. $1,903,735

Publications and Patents (Partial list)

Wang, L.; Cherian, C.; Desmoulin, S. K.; Mitchell-Ryan, S.; Hou, Z.; Matherly, L. H. and Gangjee, A. Synthesis and Biological Activity of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Inhibitors of de Novo Purine Biosynthesis with Selectivity for Cellular Uptake by High Affinity Folate Receptors and the Proton-Coupled Folate Transporter Over the Reduced Folate Carrier. J. Med. Chem., 2012. Article ASAP. DOI: 10.1021/jm201688n.

Gangjee, A.; Kurup, S.; Ihnat, M. A.; Thorpe, J. E. and Disch, B. N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as Receptor Tyrosine Kinase Inhibitors. Bioorg. Med. Chem., 2012, 20, 910-914. NIHMSID 346944; PubMed 22204741. http://www.sciencedirect.com/science/article/pii/S0968089611009941.

Gangjee, A.; Namjoshi, O. A.; Keller, S. N. and Smith, C. D. 2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as Novel Antitumor Antimitotic Agents that Also Reverse Tumor Resistance. Bioorg. & Med. Chem., 2011, 19, 4355-4365.

Zhang, X.; Zhou, Z.; Kisliuk, R. L.; Piraino, J.; Cody, V. and Gangjee, A. Design, Synthesis, Biological Evaluation and X-ray Crystal Structure of Novel Classical 6,5,6-tricyclic Benzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors. Bioorg. & Med. Chem., 2011, 19, 3585-3594.

Matherly, L. H. and Gangjee, A. Discovery of Novel Antifolate Inhibitors of de Novo Purine Nucleotide Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter Over the Reduced Folate Carrier for Cellular Entry. In Targeted Drug Strategies for Cancer and Inflammation, A. L. Jackman, C. Leamon, Eds., Springer, New York, 2011. 110-134.

Wang, L.; Desmoulin, S. K.; Cherian, C.; Polin, L.; White, K.; Kushner, J.; Fulterer, A.; Chang, M-H.; Mitchell-Ryan, S.; Stout, M.; Romero, M. F.; Hou, Z.; Matherly, L. H. and Gangjee, A. Synthesis, Biological and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity Over the Reduced Folate Carrier That Inhibits -Glycinamide Ribonucleotide Formyltransferase. J. Med. Chem., 2011, 54, 7150-7164. PubMed 21879757; NIHMSID 328244. https://www.nihms.nih.gov/pmc/articlerender.fcgi?artid=328244.

Gangjee, A.; Zhao, Y.; Hamel, E.; Westbrook, C. and Mooberry, S. L. Synthesis and Biological Activities of (R)- and (S)-N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium Chloride as Potent Cytotoxic Antitubulin Agents. J. Med. Chem., 2011, 54, 6151-6155. DOI 10.1021/jm2007722, PubMed 21786793, NIHMSID 314812.

Desmoulin, S. K.; Wang, L.; Hales, E.; Polin, L.; White, K.; Kushner, J.; Stout, M.; Hou, Z.; Cherian, C.; Gangjee, A. and Matherly, L. H. Therapeutic Targeting of a Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Transporter. Mol. Pharmacol. Fast Forward, Sept. 22, 2011, doi: 10.1124/mol.111.073833.

Gangjee, A.; Namjoshi, O. A., Ihnat, M. A. and Buchanan, A. The Contribution of a 2-Amino Group on Receptor Tyrosine Kinase Inhibition and Antiangiogenic Activity in 4-Anilinosbustituted Pyrrolo[2,3-d]pyrimidines. Bioorg. & Med. Chem. Ltrs., 2010, 20, 3177-3181. NIHMSID 192103. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866134/?tool=nihms.

Gangjee, A.; Zhao, Y.; Raghavan, S.; Ihnat, M. A. and Disch, B. C. Design, Synthesis and Evaluation of 2-Amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as Tyrosine Kinase Inhibitors and Antiangiogenic Agents. Bioorg. & Med. Chem., 2010, 18, 5261-5273. NIHMSID 210323; PubMed 20558072; Publ. ID BMC8418.

Gangjee, A.; Kurup, S.; Ihnat, M. A.; Thorpe, J. E. and Shenoy, S. S. Synthesis and Biological Activity of N4-Phenylsubstituted-6-(2,4-dichlorophenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4- diamines as Vascular Endothelial Growth Factor Receptor-2 Inhibitors and Antiangiogenic and Antitumor Agents. Bioorg. & Med Chem., 2010, 18, 3575-3587. NIHMSID 193243, PubMed 20403700. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868963/?tool=nihms.

Desmoulin, S. K.; Wang, Y.; Wu, J.; Stout, M.; Hou, Z.; Fulterer, A.; Chang, M-H.; Romero, M. F.; Cherian, C.; Gangjee, A. and Matherly, L. H. Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolate Inhibitors of de novo Purine Biosynthesis in the Chemotherapy of Solid Tumors. Mol. Pharmacol., 2010, 78, 577.587. DOI: 10.1124/mol.110.065896.

Gangjee, A.; Zhao, Y.; Lin, L.; Raghavan, S.; Roberts, E. G.; Risinger, A. L.; Hamel, E. and Mooberry, S. L. Synthesis and Discovery of Water Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance. J. Med. Chem., 2010, 53, 8116-8128. http://pubs.acs.org/doi/pdfplus/10.1021/jm101010n; http://pubs.acs.org/doi/suppl/10.1021/jm101010n/suppl_file/jm101010n_si_001.pdf; NIHMSID 248371; Publ. ID. jm101010n; PubMed # 20973488; https://www.nihms.nih.gov/pmc/articlerender.fcgi?artid=248371.

Cody, V.; Piraino, J.; Pace, J.; Li, W. and Gangjee, A. Preferential Selection of Isomer Binding From Chiral Mixutures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-Substitited 2,4-Diamino[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase. Acta. Crystal. D., 2010, D66, 1271-1277.

Gangjee, A.; Zaware, N.; Raghavan, S.; Ihnat, M.; Shenoy, S. and Kisliuk, R. L. Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido[4,5-b]indoles as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents. J. Med. Chem., 2010, 53, 1563-1578. NIHMSID 173160. PMID 20092323. http://pubs.acs.org/doi/pdf/10.1021/jm9011142.

Gangjee, A.; Lin, X.; Biondo, L. and Queener, S. F. CoMFA Analysis of tgDHFR and rlDHFR Based on Antifolates with 6-5 Fused Ring System Using the All-Orientation Search (AOS) Routine and a Modified Cross-Validated r2-Guided Region Selection (q2-GRS) Routine and Its Initial Application. Bioorg. & Med. Chem., 2010, 18, 1684-1701. DOI: 10.1016/j.bmc.2009.12.066. PMID 20117005. https://www.nihms.nih.gov/pmc/articlerender.fcgi?artid=176663.

Wang, L.; Cherian, C.; Desmoulin, S. K.; Polin, L.; Deng, Y.; Wu. J.; Hou, Z.; White, K.; Kushner, J.; Matherly, L. H. and Gangjee, A. Synthesis and Antitumor Activity of a Novel Series of 6-substituted pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry. J. Med. Chem., 2010, 53, 1306-1318. DOI: 10.1021/jm9015729. NIHMSID 171980. PMID 20085328.

Gangjee, A.; Jain, H. D.; Phan, J.; Guo, X.; Queener, S. F.; Kisliuk, R. L. 2,4-Diamino-5-methyl-6-substituted Arylthio-furo[2,3-d]pyrimidines as Novel Classical and Nonclassical Antifolates as Potential Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors. Bioorg. & Med. Chem., 2010, 18, 953-961. NIHMSID 167667. PMID 20056546.

Cody, V.; Pace, J.; Lin, L. and Gangjee, A. The Z Isomer of 2,4-Diaminofuro[2,3-d]pyrimidine Antifolate Promotes Unusual Crystal Packing in a Human Dihydrofolate Reductase Ternary Complex. Acta. Crystallogr. Sect. F, Struct. Biol. Cryst. Commun., 2009, 65, 762-766.

Gangjee, A.; Li, W.; Lin, L.; Zeng, Y.; Ihnat, M.; Warnke, L. A.; Green, D. W.; Cody, V.; Pace, J. and Queener, S. F. Design, Synthesis and X-ray Crystal Structures of 2,4-Diaminofuro[2,3-d]pyrimidines as Multireceptor Tyrosine Kinase and Dihydrofolate Reductase Inhibitors. Bioorg. & Med. Chem., 2009, 17, 7324-7336. NIHMS 14021. PMID 19748785.

Gangjee, A.; Li, W.; Kisliuk, R. L.; Cody, V.; Pace, J.; Piraino, J. and Makin, J. Design, Synthesis and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents. J. Med. Chem., 2009, 52, 4892-4902. "http://pubs.acs.org/doi/pdfplus/10.1021/jm900490a. NIHMSID # 133294.

Deng, Y,; Zhou, X.; Desmoulin, S.K.; Wu, J.; Cherian, C.; Hou, Z.; Matherly, L. H. and Gangjee, A. Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors Over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry. J. Med. Chem., 2009, 52, 2940-2951. http://pubs.acs.org/doi/pdfplus/10.1021/jm8011323. PMID 19371039.

Gangjee, A.; Adair, O. O.; Pagley, M. and Queener, S. F. N9-Substituted 2,4-Diaminoquinazolines: Synthesis and Biological Evaluation of Lipophilic Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase. J. Med. Chem., 2008, 51, 6195-6200. http://pubs.acs.org/doi/abs/10.1021/jm800694g.

Gangjee, A.; Qiu, Y.; Li, W. and Kisliuk, R. L. Potent Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors: Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine Antifolates. J. Med. Chem., 2008, 51, 5789-5797. http://pubs.acs.org/doi/abs/10.1021/jm8006933.

Deng, Y.; Wang, Y.; Cherian, C.; Hou, Z.; Buck S. A.; Matherly, L. H. and Gangjee, A. Synthesis and Discovery of High Affinity Folate Receptor-Specific Glycinamide Ribonucleotide Formyltransferase Inhibitors with Antitumor Activity. J. Med. Chem., 2008, 51, 5052-5063.

Gangjee, A.; Jain, H. D.; Queener, S. F. and Kisliuk, R. L. The Effect of 5-Alkyl Modification on the Biological Activity of Pyrrolo[2,3-d]pyrimidine Containing Classical and Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductase and as Antitumor and/or Antiopportunistic Infection Agents. J. Med. Chem., 2008, 51, 4589-4600.

Gangjee, A., Namjoshi, O. A.; Yu, J.; Ihnat, M. A.; Thorpe, J. E. and Warnke, L. A. Design, Synthesis and Biological Evaluation of Substituted Pyrrolo[2,3-d]pyrimidines as Multiple Receptor Tyrosine Kinase Inhibitors and Antiangiogenic Agents. Bioorg. & Med. Chem., 2008, 16, 5514-5528.

Gangjee, A.; Jain, H. D. and Kurup, S. Recent Advances in Classical and Non-classical Antifolates as Antitumor and Antiopportunistic Infection Agents, Part II. Anti-Cancer Agents in Med. Chem., 2008, 8, 205-231.

Deng, Y.; Hou, Z.; Wang, L.; Cherian, C.; Wu, J.; Gangjee, A. and Matherly, L. H. Role of Lysine 411 in Substrate Carboxyl Group binding to the Human Reduced Folate Carrier, as Determined by Site-directed Mutagenesis and Affinity Inhibition. Mol. Pharmacol., 2008, 73, 1274-1281.

Gangjee, A.; Li, W.; Yang, J. and Kisliuk, R. L. Design, Synthesis and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors. J. Med. Chem., 2008, 51, 68-76.

Gangjee, A.; Jain, H.D. and Kurup, S. Recent Advances in Classical and Non-classical Antifolates as Antitumor and Antiopportunistic Infection Agents, Part II. Anti-Cancer Agents in Med. Chem., 2008, 8, 205-231.

Gangjee, A.; Jain, H. D.; Queener, S. F. and Kisliuk, R. L. The Effect of 5-Alkyl Substitution on Dual Inhibitory Activity Against Dihydrofolate Reductase and Thymidylate Synthase in Pyrrolo[2,3-d]pyrimidines. In the proceedings of the 13th International Symposium on Chemistry & Biology of Pteridines and Folates, 2007, 1, 84-90.

Gangjee, A.; Jain, H.D. and Kurup, S. Recent Advances in Classical and Non-classical Antifolates as Antitumor and Antiopportunistic Infection Agents, Part I. Anti-Cancer Agents in Med. Chem., 2007. 7, 524-542

Gangjee, A.; Kurup, S. and Namjoshi, O. A. Dihydrofolate Reductase as a Target for Chemotherapy in Parasites. Current Pharm. Design, 2007, 13, 609-639.

Gangjee, A.; Yu, J.; Copper, J. E. and Smith, C. D. Discovery of Novel Antitumor Antimitotic Agents That Also Reverse Tumor Resistance. J. Med. Chem., 2007, 50, 3290-3301.

Gangjee, A.; Zeng, Y.; Talreja, T.; McGuire, J. J.; Kisliuk, R. L. and Queener, S. F. Design and Synthesis of Classical and Nonclassical, 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates. J. Med. Chem., 2007, 50, 3046-3053

Gangjee, A.; Jain, H. D.; Phan, J.; Lin, X.; Song, X.; McGuire, J. J. and Kisliuk, R. L. Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase as Antitumour Agents: Design, Synthesis and Biological Evaluation of Classical and Nonclassical Pyrrolo[2,3-d]pyrimidine Antifolates. J. Med. Chem., 2006, 49, 1055-1065.

Gangjee, A.; Yang, J. and Queener, S. F. Novel Nonclassical C9-Methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as Potential Inhibitors of Dihydrofolate Reductase and as Anti-opportunistic Agents. Bioorganic & Medicinal Chemistry, 2006, 14, 8341-8351.

Gangjee, A.; Yang, J.; McGuire, J. J. and Kisliuk, R. L. Synthesis and Evaluation of a Classical 2,4-Diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-Amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as Antifolates. Bioorganic & Medicinal Chemistry, 2006, 14, 8590-8598.

Gangjee, A.; Wang, Y.; Queener, S. F. and Kisliuk, R. L. Synthesis of 2,6-Diamino-5-[(2-substituted phenylamino)ethyl]pyrimidin-4(3H)-one as Inhibitors of Folate Metabolizing Enzymes. J. Heterocyclic Chem., 2006, 43, 1523-1531.

Gangjee, A. and Lin, X. COMFA and COMSIA Analyses of Pneumocystis carinii Dihydrofolate Reductase, Toxoplasma gondii Dihydrofolate Reductase and Rat Liver Dihydrofolate Reductase. J. Med. Chem., 2005, 48, 1448-1469.

Gangjee, A.; Jain, H. D. and Kisliuk, R. L. Novel 2-Amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase. Bioorg. & Med. Chem. Ltrs., 2005, 15, 2225-2230.

Gangjee, A.; Jain, H. D. and Queener, S. F. Design, Synthesis and Biological Evaluation of 2,4-Diamino-6-methyl-5-substituted-pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors. J. Heterocyclic Chem., 2005, 42, 589-594.

Gangjee, A.; Zeng, Y.; McGuire, J. J. and Kisliuk, R. L. Synthesis of Classical, Four-carbon-bridged 5-Substituted Furo[2,3-d]pyrimidine and 6-Substituted Pyrrolo[2,3-d]pyrimidine Analogues as Antifolates. J. Med. Chem., 2005, 48, 5329-5336.

Gangjee, A.; Zeng, Y.; Ihnat, M.; Warnke, L. A.; Green, D. W.; Kisliuk, R. L. and Lin, F-T. Novel 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Multi-receptor Tyrosine Kinase and Dihydrofolate Reductase Inhibitors with Antiangiogenic and Antitumor Activity. Bioorganic and Medicinal Chemistry, 2005, 13, 5475-5491.

Gangjee, A.; Ye, Z. and Queener, S. F. Synthesis of Three Carbon Atom Bridged 2,4-Diaminopyrrolo[2,3-d]pyrimidines as Nonclassical Dihydrofolate Reducatse Inhibitors. J. Heterocyclic Chem., 2005, 42, 1127-1133.

Gangjee, A.; Lin, X.; Kisluk, R. L. and McGuire, J. J. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic Acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic Acid as Dual Inhibitors of Dihydrofolate Reductase and Thymidylate Synthase, and as Potential Antitumor Agents. J. Med. Chem., 2005, 48, 7215-7222

Cody, V.; Luft, J. R.; Pangborn, W.; Gangjee, A. and Queener, S. F. Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry. Acta Cryst., 2004, D60, 646-655.

Li, W.; Favelyukis, S.; Yang, J.; Zeng, Y.; Yu, J.; Jain, H.; Gangjee, A. and Miller, W. T. Inhibition of Insulin-like Growth Factor I Receptor Autophosphorylation by Novel 6-5 Ring-fused Compounds. Biochem. Pharm., 2004, 68, 145-154.

Gangjee, A.; Lin, X. and Queener, S. F. Design, Synthesis and Biological Evaluation of 2,4-Diamino-5-methyl-6-substituted Pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors. J. Med. Chem., 2004, 47, 3689-3692.

Gangjee, A. and Jain, H. D. Antifolates - Past, Present and Future. Curr. Med. Chem. - Anti-Cancer Agents, 2004, 4, 405-410.

Gangjee, A.; Qiu, Y. and Kisliuk, R. L. Synthesis of Classical and Nonclassical 2-Amino-4-oxo-6-benzythieno[2,3-d]pyrimidines as Potential Thymidylate Synthase Inhibitors. J. Heterocyclic Chem., 2004, 41, 941-946.

Gangjee, A.; Zeng, Y.; McGuire, J. J.; Mehraein, F. and Kisliuk, R. L. Synthesis of Classical, Three Carbon Bridged 5-Substituted Furo[2,3-d]pyrimidine and 6-Substituted Pyrrolo[2,3-d]pyrimidine Analogues as Antifolates. J. Med. Chem., 2004, 47, 6893-6901.

Gangjee, A.; Jain, H. D.; McGuire, J. J. and Kisliuk, R. L. Benzoyl Ring Halogenated Classical 2-Amino-6-methyl-3,4-dihydro-4-oxo-5-substituted Thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine Antifolates as Inhibitors of Thymidylate Synthase and as Antitumor Agents. J. Med. Chem., 2004, 47, 6730-6739.

Gangjee, A.; Jain, H. D.; Phan, J. and Kisliuk, R. L. Synthesis of 2-Amino-4-oxo-5-substitutedbenzylthio-pyrrolo[2,3-d]pyrimidines as Potential Inhibitors of Thymidylate Synthase. J. Heterocyclic Chem., 2004, 42, 165-168.

Recent Presentations (Partial list)

Pavana, R. K.; Gangjee, A.; Hamel, E. and Mooberry, S. L. Design, Synthesis and Biological Evaluation of Novel, Conformationally Restricted, Water Soluble, Substituted Pyrrolo[3,2-d]pyrimidines as Antitubulin Antitumor Agents. Presented at the 242nd American Chemical Society (ACS) National Meeting in Denver, CO on Aug. 28-Sept. 1, 2011. MEDI 48.

Zaware, N.; Gangjee, A.; Mooberry, S. L. and Hamel, E. Synthesis and Biological Evaluation of N4-(substitutedphenyl)-N4-methyl/desmethyl-9H-pyrimido[4,5-b]indole-2,4-diamines as Antimitotic Agents. Presented at the 242nd American Chemical Society (ACS) National Meeting in Denver, CO on Aug. 28-Sept. 1, 2011. MEDI 52.

Devambatla, R. K. V.; Gangjee, A.; Zaware, N.; Mooberry, S. L. and Hamel, E. Synthesis and Biological Evaluation of 5-Chloro-N4-substituted-N4-methyl-9H-pyrimido[4,5-b]indole-2,4-diamines as Antimitotic Agents. Presented at the 242nd American Chemical Society (ACS) National Meeting in Denver, CO on Aug. 28-Sept. 1, 2011. MEDI 53.

Zhao, S.; Gangjee, A.; Wang, L.; Matherly, L. H. and Kisliuk, R. L. 2-Methyl-6-substituted Pyrrolo[2,3-d]pyrimidine Classical Antifolates as Selective Folate Receptor Substrates, Glycinamide Ribonucleotide Formyltransferase Inhibitors and Antitumor Agents. Presented at the 242nd American Chemical Society (ACS) National Meeting in Denver, CO on Aug. 28-Sept. 1, 2011. MEDI 58.

Raghavan, S.; Gangjee, A.; Zhao, Y.; Mooberry, S. L. and Hamel, E. Synthesis and Biological Evaluation of the R- and S-enantiomers of the Antitubulin 6-Methyl Cyclopenta[d]pyrimidines as Cytotoxic Agents that Parallel Predicted Antitubulin Activities. Presented at the 242nd American Chemical Society (ACS) National Meeting in Denver, CO on Aug. 28-Sept. 1, 2011. MEDI 269.

Gangjee, A.; Zhao, Y.; Westbrook, C.; Nawrocki, S.; Mooberry, S. and Hamel, E. Synthesis of Novel Water Soluble Small Molecule Antitubulin Agents with Antitumor Activity That Circumvent Resistance to Pgp and -III Tubulin. Presented at the 12th Tetrahedron Symposium in Sitges, Spain, June 21-24, 2011.

Wang, L.; Cherian, C.; Desmoulin, S. K.; Hou, Z.; Matherly, L. H. and Gangjee, A. Design, Synthesis and Evaluation of Potent Antiproliferative and Cytotoxic Antifolates with Selective FRs and PCFT Transport Over RFC and Potent GARFTase Inhibition. Presented at the 102nd Annual Meeting of the American Association for Cancer Research (AACR) in Orlando, FL, April 2-6, 2011. Abstract No: 1364.

Gangjee, A.; Zaware, N.; Kisliuk, R. L. and Ihnat, M. A. Substituted Pyrimido[4,5-b]indoles with Single Agent Combination Chemotherapeutic Potential. Presented at the 102nd Annual Meeting of the American Association for Cancer Research (AACR) in Orlando, FL, April 2-6, 2011. Abstract No: 1367.

Desmoulin, S. K.; Wang, L.; Tait, L.; Polin, L.; Hou, Z.; Cherian, C.; Gangjee, A. and Matherly, L. H. Therapeutic Targeting of a Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by PCFT. Presented at the 102nd Annual Meeting of the American Association for Cancer Research (AACR) in Orlando, FL, April 2-6, 2011. Abstract No: 2528.

Gangjee, A.; Zhang, X.; Namjoshi, O.; Devambatla, R. K. V.; Hamel, E. and Mooberry, S. L. Design, Synthesis and Biological Evaluation of Substituted Furo[2,3-d]pyrimidines as Potent Microtubule Targeting Antitumor Agents That Circumvent Pgp and III-tubulin Mediated Resistance. Presented at the 102nd Annual Meeting of the American Association for Cancer Research (AACR) in Orlando, FL, April 2-6, 2011. Abstract No: 3244.

Wang, Y.; Mitchell, S.; Cherian, C.; Desmoulin, S. K.; Hou, Z.; Kisliuk, R. L.; Matherly, L. H. and Gangjee, A. Design, Synthesis and Biological Evaluation of Side Chain Pemetrexed (PMX) Analogues as Potent Inhibitors of Tumors Expressing Folate Receptors via GARFTase Inhibition. Presented at the 102nd Annual Meeting of the American Association for Cancer Research (AACR) in Orlando, FL, April 2-6, 2011. Abstract No: 3250.

Pavana, R. K.; Gangjee. A. and Ihnat, M. A. 7-Benzyl-2-methyl-N-substituted Phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-amines as Receptor Tyrosine Kinase Inhibitors: Design, Synthesis and Biological Evaluation. Presented at the 241st American Chemical Society National Meeting, March 27-31, 2011, Anaheim, CA. MEDI 263.

Gangjee, A. Synthesis and Discovery of Water Soluble Microtubul Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance. Invited podium presentation at the National Institutes of Health, National Cancer Institute, Nov. 3, 2010, Frederick, MD.

Pavana, R. K.; Gangjee, A. and Ihnat, M. A. Design, Synthesis and Evaluation of 7-Benzyl-2-methyl-N-substituted-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-amines as Receptor Tyrosine Kinase Inhibitors. Presented at the 2nd Annual Mylan School of Pharmacy Student Research Symposium, Co-hosted by the University of Pittsburgh School of Pharmacy AAPS Chapter, Oct. 20, 2010, Pittsburgh, PA. Poster # 36.

Raghavan, S. and Gangjee, A. CoMFA Analysis of Pyrrolo[2,3-d]pyrimidines and Furo[2,3-d]pyrimidines as Multiple Receptor Tyrosine Kinase Inhibitors. Presented at the 2nd Annual Mylan School of Pharmacy Student Research Symposium, Co-hosted by the University of Pittsburgh School of Pharmacy AAPS Chapter, Oct. 20, 2010, Pittsburgh, PA. Poster # 37.

Gangjee, A.; Wang, Y.; Desmoulin, S. K.; Cherian, C.; Matherly, L. H. and Kisliuk, R. L. Design, Synthesis and Biological Evaluation of Pemetrexed (PMX) Homologs for Folate Receptor Targeting Multiple Enzyme Antifolates. Presented at the 2nd Annual Mylan School of Pharmacy Student Research Symposium, Co-hosted by the University of Pittsburgh School of Pharmacy AAPS Chapter, Oct. 20, 2010, Pittsburgh, PA. Poster # 40.

Gangjee, A. Synthesis, Evaluation and SAR of FR and PCFT Specific Antitumor Agents. Podium presentation at The Third International Symposium on Folate Receptors and Transporters, Oct. 12-15, 2010, Zion National Park, UT.

Gangjee, A.; Zhao, Y. and Mooberry, S. Discovery of Water Soluble N,2-dimethyl-N-substituted Phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amines as Antimitotic Agents that Circumvent Taxol Resistance. Presented at the 240th American Chemical Society National Meeting, August 22-26, 2010, Boston, MA. MEDI 52.

Gangjee, A.; Lin, L. and Hamel, E. Discovery of Substituted Pyrrolo[2,3-d]pyrimidines as Water Soluble Antitubulin Antitumor Agents. Presented at the 240th American Chemical Society National Meeting, August 22-26, 2010, Boston, MA. MEDI 53.

Wang, Y.; Desmoulin, S. K.; Cherian, C.; Matherly, L. H.; Kisliuk, R. L. and Gangjee, A. Design, Synthesis and Biological Evaluation of Pemetrexed (PMX) Homologs for Folate Receptor Targeting Multiple Enzyme Antifolates. Presented at the 240th American Chemical Society National Meeting, August 22-26, 2010, Boston, MA. MEDI 87.

Zhao, S.; Cherian, C.; Desmoulin, S. K.; Matherly, L. H.; Kisliuk, R. L. and Gangjee, A. 2-Desamino and 2-Methyl-6-substituted Pyrrolo[2,3-d]pyrimidine Classical Antifolates as Selective Folate Receptor Substrates, Glycinamide Ribonucleotide Formyltransferase Inhibitors and Antitumor Agents. Presented at the 240th American Chemical Society National Meeting, August 22-26, 2010, Boston, MA. MEDI 89

Raghavan, S and Gangjee, A. CoMFA Analysis of Pyrrolo[2,3-d]pyrimidines and Furo[2,3-d]pyrimidines as Multiple Receptor Tyrosine Kinase Inhibitors. Presented at the 240th American Chemical Society National Meeting, August 22-26, 2010, Boston, MA. MEDI 401.

Gangjee, A.; Zhou, X.; Cherian, C.; Desmoulin, S. K. and Matherly, L. H. Classical 6-Substituted Thieno[2,3-d]pyrimidine as GARFTase Inhibitor. Presented at the 240th American Chemical Society National Meeting, August 22-26, 2010, Boston, MA.

Gangjee, A.; Wang, L.; Cherin, C.; Hou, Z.; Desmoulin, S. K.; Matherly, L. H. and Kisliuk, R. L. The Design, Synthesis and in vitro Evaluation of Selective FR α and β and PCFT Substrates with Potent GARFTase Inhibitory Activity as Antitumor Agents. Presented at the 101st Annual Meeting of the American Association for Cancer Research (AACR) in Washington, DC, April 17-21, 2010. Poster Number 4542/22.

Desmoulin, S. K.; Wang, L.; Tait, L,; Hou, Z.; Cherin, C.; Gangjee, A. and Matherly, L. H. Expression Profiling of the Major Folate Facilitative Transporters in Human Tumors and Normal Tissues. Presented at the 101st Annual Meeting of the American Association for Cancer Research (AACR) in Washington, DC, April 17-21, 2010. Poster Number 4546/26.

Gangjee, A.; Zhou, X.; Zhang, X. and Kisliuk, R. L. Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-propyl Thieno[2,3-d]pyrimidine as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors. Presented at the 239th American Chemical Society National Meeting in San Francisco, CA, March 21-25, 2010. MEDI 239.

Gangjee, A.; Zhang, X.; Zhou, X. and Matherly, L. H. Importance of the Glutamate Moiety for Folate Receptor Targeting and GARFTase Inhibitory Activity in Classical Thieno[2,3-d]pyrimidine Antifolates. Presented at the 239th American Chemical Society National Meeting in San Francisco, CA, March 21-25, 2010. MEDI 238.

Wang, L.; Gangjee, A. and Kisliuk, R. L. Synthesis of 2,4-Diamino-pyrimido[4,5-b]indoles as Inhibitors of Dihydrofolate Reductase. Presented at the 1st Annual Research Symposium, Mylan School of Pharmacy and the Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, Oct. 20, 2009. Poster # 6.

Devambatla, R.; Gangjee, A.; Zaware, N.; Yang, J. and Kisliuk, R. L. Design, Synthesis and Biological Evaluation of 2-Amino-5-substituted-3,9-dihydro-4H-pyrimido[4,5-b]indol-4-ones as Potent Inhibitors of Toxoplasma gondii Thymidylate Synthase. Presented at the 1st Annual Research Symposium, Mylan School of Pharmacy and the Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, Oct. 20, 2009. Poster # 3.

Gangjee, A.; Pavana, R. K. and Ihnat, M. A. Design and Synthesis of 7-(3,4,5-Trimethoxybenzyl)-N4-substituted Phenyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-diamines as Receptor Tyrosine Kinase Inhibitors. Presented at the 238th American Chemical Society National Meeting in Washington DC, August 16-20, 2009. MEDI 366.

Gangjee, A.; Zhao, Y, and Ihnat, M. A. Novel (E)-9-benzylidene-N4-substituted-9H-indeno[2,1-d]pyrimidine-2,4-diamines as Multiple RTK Inhibitors. Presented at the 238th American Chemical Society National Meeting in Washington DC, August 16-20, 2009. MEDI 141.

Gangjee, A.; Zaware, N.; Yang, J.; Devambatla, R. K. V. and Kisliuk, R. L. Design, Synthesis and Biological Evaluation of 2-Amino-5-substituted-3,9-dihydro-4H-pyrimido[4,5-b]indol-4-ones as Potent Inhibitors of Toxoplasma gondii Thymidylate Synthase. Presented at the 238th American Chemical Society National Meeting in Washington DC, August 16-20, 2009. MEDI 117.

Gangjee, A.; Wang, L. and Kisliuk, R. L. Synthesis of 2,4-Diamino-pyrimido[4,5-b]indoles as Inhibitors of Dihydrofolate Reductase. Presented at the 238th American Chemical Society National Meeting in Washington DC, August 16-20, 2009. MEDI 72.

Gangjee, A.; Zhang, X.; Li, W.; Zeng, Y, and Kisliuk, R. L. Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-methylfuro[2,3-d]pyrimidine Antifolates as Thymidylate Synthase Inhibitors. Presented at the 238th American Chemical Society National Meeting in Washington DC, August 16-20, 2009. MEDI 70.

Gangjee, A.; Devambatla, R. K. V.; Zaware, N. and Ihnat, M. A. Efficient Large Scale Synthesis of 5-(Phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamine: A Potent Dual Inhibitor of Thymidylate Synthase and Multiple Receptor Tyrosine Kinases. Presented at the 42nd Annual Mid-Atlantic Graduate Student Symposium (MAGSS) in Medicinal Chemistry, Toledo, OH, June 21-23, 2009.

Cody, V.; Pace, J.; Piraino, J.; Queener, S. F. and Gangjee, A. Conformational Flexibility in the binding of a thieno[2,3-d]pyrimidine Antifolate to Human Dihydrofolate Reductase Active Site Mutants. Presented at the 100th Annual Meeting of the American Association for Cancer Research (AACR) in Denver, CO, April 18-22, 2009. Abstract No: 5361.

Cody, V.; Freindorf, M.; Furlani, T.; Queener, S. F. and Gangjee, A. Correlations of the Kinetic Properties and Computational Qm/MM Modeling of Potent Dihydrofolate Reductase Inhibitors. Presented at the 100th Annual Meeting of the American Association for Cancer Research (AACR) in Denver, CO, April 18-22, 2009. Abstract No: 2458.

Desmoulin, S. K.; Wang, Y.; Wu, J.; Hou, Z.; Cherian, C.; Gangjee, A. and Matherly, L. H. Discovery of a Glycinamide Ribonucleotide Formyltransferase Inhibitor with Solid Tumor Selectivity via its Transport by the Proton-coupled Folate Transporter. Presented at the 100th Annual Meeting of the American Association for Cancer Research (AACR) in Denver, CO, April 18-22, 2009. Abstract No: 1684.

Gangjee, A.; Zaware, N.; Kisliuk, R. L. and Ihnat, M. A. The Design of Combination Chemotherapeutic Potential in Single Agents. Presented at the 100th Annual Meeting of the American Association for Cancer Research (AACR) in Denver, CO, April 18-22, 2009. Abstract No: 656.

Wang, L.; Desmoulin, S. K.; Polin, L.; Cherian, C.; Deng, Y.; Matherly, L. H. and Gangjee, A. The Design, Synthesis and Preclinical Evaluation of Selective FR and PCFT Substrates With Potent GARFTase Inhibitory Activity as Antitumor Agents. Invited podium presentation at the 100th Annual Meeting of the American Association for Cancer Research (AACR) in Denver, CO, April 18-22, 2009. Abstract No: 1918.

Gangjee, A.; Zhao, Y. and Ihnat, M. A. Novel N4-Phenyl Substituted Tricyclic Indeno[1,2-d]pyrimidines as Tyrosine Kinase Inhibitors and Antiangiogenic Agents. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 219.

Gangjee, A.; Zaware, N. and Ihnat, M. A. Design, Synthesis and Evaluation of 5-Chloro-N4-substituted Phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as Potential Inhibitors of Multiple Receptor Tyrosine Kinases. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 226.

Gangjee, A.; Zhou, X.; Li, W. and Kisliuk, R. L. Classical and Nonclassical 2-Amino-4-oxo-5-arylthio-substituted-6-isopropyl Thieno[2,3-d]pyrimidine Antifolates as Potent Thymidylate Synthase Inhibitors. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 95. Received a $1,000 MEDI Travel Grant.

Gangjee, A. and Zhao, S. Design, Synthesis and Biological Evaluation of 2-Desamino-4-alkyl-5-[(substituted phenyl)ethyl]-7substituted Pyrrolo[2,3-d]pyrimidines as Antitumor Antimitotic Agents. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 94.

Gangjee, A.; Zhang, X.; Zhou, X. and Kisliuk, R. L. Synthesis of 2-Methyl-4-oxo-benzo[4,5]thieno[2,3-d]pyrimidine as TS Inhibitor. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 93.

Gangjee, A.; Wang, Y.; Deng, Y.; Cherian, C.; Hou, Z. and Matherly, L. H. The Importance of the Glutamate Moiety for Folate Receptor Targeting and GARFTase Inhibitory Activity in Classical Pyrrolo[2,3-d]pyrimidine Antifolates. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 65.

Gangjee, A.; Wang, L.; Matherly, L. H.; Deng, Y. and Kisliuk, R. L. Synthesis of Classical 6-Substituted Pyrrolo[2,3-d]pyrimidines as GARFTase Inhibitors With Folate Receptor (FR) Specificity and Antitumor Activity. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 64.

Gangjee, A.; Raghavan, S.; Li, W.; Queener, S. F. and Cody, V. Synthesis and Biological Evaluation of 2,4-Diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as Inhibitors of Pneumocystis jirovecii and Toxoplasma gondii Dihydrofolate Reductase. Presented at the 237th American Chemical Society (ACS) National Meeting in Salt Lake City, UT, March 22-26, 2009. MEDI 63. Received a $1,000 MEDI Travel Grant.

Gangjee, A. Design of Combination Chemotherapeutic Potential in Single Agents. Seminar presentation, Department of Chemistry, Bayer School of Natural and Environmental Sciences, Duquesne University, Pittsburgh, PA, March 20, 2009.

Gangjee, A. Synthesis and Evaluation of Folate Receptor Specific Antitumor Agents. Invited podium presentation at the 2nd International Meeting on Folate Receptors and Carriers, Villa Vigoni, Como, Italy, Oct. 26-30, 2008.

Gangjee, A.; Li, W.; Qiu, Y.; Kisliuk, R. L. and Queener, S. F. Design, Synthesis and Biological Evaluation of 2,4-Diamino-5-methyl-6-substituted-thieno[2,3-d]pyrimidine: A Novel Classical Antifolate with Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitory Activity as Potential Antitumor Agent. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 130.

Gangjee, A.; Zhao, Y. and Ihnat, M. A. Novel 4-Phenylsulfanyl Substituted Tricyclic Indeno[2,1-d]pyrimidines as Tyrosine Kinase Inhibitors and Antiangiogenic Agents. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 156.

Gangjee, A.; Zhang, X.; Kisliuk, R. L. and Queener, S. F. Design, Synthesis and Evaluation of 6-6 Fused Bicyclic Nonclassical Pneumocystis jirovecii (pj) and Toxoplasma gondii (tg) Dihydrofolate Reductase (DHFR) Selective Inhibitors. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 341.

Gangjee, A.; Kurup, S. and Ihnat, M. A. Synthesis and Biological Activity of 2-Desamino-4-substituted Anilino-6-substituted Phenylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 362.

Gangjee, A.; Zaware, N.; Yang, J. and Ihnat, M. A. N4-(3-Bromophenyl)-7-(substitutedbenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,3-diamines as Novel Potent Multiple Receptor Tyrosine Kinase Inhibitors. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 373.

Gangjee, A.; Zhou, X.; Deng, Y,; Matherly, L. H. and Kisliuk, R. L. Classical 6-Substituted Thieno[2,3-d]pyrimidines as GARFTase Inhibitors with Folate Receptor (FR) Specificity and Antitumor Activity. Presented at the 236th American Chemical Society (ACS) National Meeting, Philadelphia, PA, August 17-21, 2008. MEDI 157.

Gangjee, A.; Zhao, Y.; Ihnat, M. A. and Kisliuk, R. L. Novel Tricyclic Indeno[2,1-d]pyrimidines with Dual Cytostatic and Cytotoxic Activities as Antitumor Agents. Presented at the American Association for Cancer Research (AACR) Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract no. 1295.

Gangjee, A.; Wang, Y.; Deng, Y.; Cherian, C.; Hou, Z. and Matherly, L. H. Discovery of -Folate Receptor Specific GARFTase Inhibitors as Selective Antitumor Agents. Presented at the American Association for Cancer Research (AACR) Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract no. 1309.

Cody, V.; Pace, J. B.; Gangjee, A.; Lin, L.; Zeng, L. and Queener, S. F. Alternate Binding Modes Observed for E- and Z-Isomers of 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH in Mouse Dihydrofolate Reductase. Presented at the American Association for Cancer Research (AACR) Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract no. 3188.

Deng, Y.; Wang, Y.; Cherian, C.; Hou, Z.; Taub, J. W.; Gangjee, A. and Matherly, L. H. A Series of Novel 6-Substituted 2-Amino-4-oxopyrrolo[2,3-d]pyrimidine Antifolates Specifically Transported by Folate Receptors and Targeting the de novo Purine Biosynthesis Pathway. Presented at the American Association for Cancer Research (AACR) Annual Meeting, San Diego, CA, April 12-16, 2008. Abstract no. 3288.

Gangjee, A.; Smith, C. D. and Zaware, N. Synthesis and Evaluation of Potential Antitumor Antimitotics That Also Reverse Tumor Resistance. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 107.

Gangjee, A.; Kurup, S. and Smith, C. D. Synthesis of 7-Substituted Benzyl-5-[(3,4,5-trimethoxyphenyl)ethyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as Microtubule Inhibitors. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 074.

Gangjee, A.; Zhang, X. and Smith, C. D. Synthesis of Substituted Pyrrolo[2,3-d]pyrimidines with N7 Chain Length Difference as Novel Antitumor Antimitotic Agents That Also Reverse Tumor Resistance. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 108.

Gangjee, A.; Zhou, X.; Zhang, X. and Kisliuk, R. L. Synthesis of Benzo[4,5]thieno[2,3-d]pyrimidine as Potential Dual TS and DHFR Inhibitor. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 109.

Gangjee, A.; Wang, L. and Kisliuk, R. L. Synthesis of Pyrimido[4,5-b]indoles as Selective Inhibitors of Toxoplasma gondii Dihydrofolate Reductase. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 224.

Gangjee, A.; Li, W. and Queener, S. F. Design, Synthesis and Biological Evaluation of 5-Substituted-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-diamines as Dihydrofolate Reductase Inhibitors. Presented at the 235th American Chemical Society (ACS) National Meeting, New Orleans, LA, April 6-10, 2008, MEDI 297.

Gangjee, A. From the Design of Antifolates to Tyrosine Kinase Inhibitors and Beyond. Plenary presentation at the 15th Mainzer Forum "Medicinal Chemistry," Kinase Inhibitors - From Biology to Clinic, Johnannes Gutenberg Universität, Institute of Pharmacy, Mainz, Germany, September 28, 2007.

Gangjee, A.; Namjoshi, O.; Zhao, Y. and Smith, C. D. Synthesis and Evaluation of Substituted Pyrrolo[2,3-d]pyrimidines as Antitumor Antimitotics That Also Reverse Tumor Resistance. Podium presentation at the 6th Asian Federation for Medicinal Chemistry (AFMC) International Medicinal Chemistry Symposium, Istanbul, Turkey, July 8-11, 2007. OP-60.

Gangjee, A.; Zaware, N.; Keller, S. N. and Smith, C. D. Antitubulin 7-Benzyl-4-methyl-5-(2-substituted phenyl ethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amines as Potential Antitumor Agents and P-glycoprotein Modulators. Presented at the 40th Annual Mid-Atlantic Graduate Student Symposium (MAGSS), West Virginia University, Department of Basic Pharmaceutical Sciences, C. Eugene Bennett Department of Chemistry, Morgantown, WV, June 10-12, 2007.

Gangjee, A.; Zhao, Y.; Smith, C. D. and Keller, S. N. Substituted Pyrrolo[2,3-d]pyrimidines as Antitumor Antimitotic Agents With Tumor Resistance Reversing Attributes. Presented at the 40th Annual Mid-Atlantic Graduate Student Symposium (MAGSS), West Virginia University, Department of Basic Pharmaceutical Sciences, C. Eugene Bennett Department of Chemistry, Morgantown, WV, June 10-12, 2007.

Deng, Y.; Zhanjun, H.; Cherian, C.; Hou, Z.; Wu, J.; Wang, L.; Gangjee, A. and Matherly, L. H. Identification of Human Reduced Folate Carrier (hRFC) Substrate Binding Sites by Site-directed Mutagenesis and Affinity Labeling Strategies. Podium presentation at the American Association for Cancer Research (AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007. Abstract no. 5731.

Gangjee, A.; Yang, J.; Li, W. and Kisliuk, R. L. Design, Synthesis and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methyl-pyrrolo[3,2-d]pyrimidines as Potential Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors. Presented at the American Association for Cancer Research (AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007. Abstract no. 2411.

Gangjee, A.; Wang, L.; Deng, Y.; Cherian, C.; Matherly, L. H. and Kisliuk, R. L. Synthesis of 2,4-Diamino-5-substituted-furo[2,3-d]pyrimidines as Potential Substrates for the RFC and as Classical Antifolate Analogs. Presented at the American Association for Cancer Research (AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007. Abstract no. 4865.

Gangjee, A.; Zhao, Y.; Smith, C. D. and Keller, S. N. Design and Synthesis 7-Substituted-benzyl-5-[2-(2-methyoxyl-phenyl)-ethyl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamine as Microtubule Inhibitors. Presented at the American Association for Cancer Research (AACR) Annual Meeting, Los Angeles, CA, April 14-18, 2007. Abstract no. 3958.

Gangjee, A.; Namjoshi, O. A.; Keller, S. N. and Smith, C. D. 2-Amino-4-methyl-5-phenylethylsubstituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as Novel Antitumor Antimitotic Agents That Also Reverse Tumor Resistance. Presented at the 233rd American Chemical Society National Meeting, Chicago, IL, March 25-29, 2007. MEDI 169.

Gangjee, A.; Kurup, S.; Ihnat, M. A. and Green D. Synthesis and Biological Activity of 2-Amino-4-substituted Anilino-6-substituted Phenylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases. Presented at the 233rd American Chemical Society National Meeting, Chicago, IL, March 25-29, 2007. MEDI 113.

Gangjee, A., Namjoshi, O. A.; Ihnat, M. A.; Warnke, L. A. and Thorpe, J. E. Design and Synthesis of 2-Amino-4-anilino-6-substituted Pyrrolo[2,3-d]pyrimidines as Antiangiogenic Agents. Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006. MEDI 432.

Gangjee, A.; Yu, J.; Keller, S. N. and Smith, C. D. Discovery of Novel Antitumor Antimitotic Agents that Also Reverse Tumor Resistance. Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006. MEDI 142.

Gangjee, A.; Jain, H. D.; Queener, S. F. and Kisliuk, R. L. Non-classical 5-Aryl-furo[2,3-d]pyrimidines and 6-Aryl-pyrrolo[2,3-d]pyrimidines as Potential Dihydrofolate Reductase and/or Thymidylate Synthase Inhibitors. Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006. MEDI 140.

Gangjee, A.; Zhou, X.; Kisliuk, R. L. and Queener, S. F. 2,4-Dimino-6-aryl Thieno[2,3-d]pyrimidines as Potential Dihydrofolate Reductase Inhibitors. Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006. MEDI 138.

Gangjee, A.; Wang, L.; Matherly, L. H.; Deng, Y. and Kisliuk, R. L. Synthesis of Classical diaminofuro[2,3-d]pyrimidine Analogs as Antifolates. Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006. MEDI 143.

Gangjee, A.; Li, W.; Ihnat, M.; Warnke, L. A.; Thorpe, J. E.; Miller, W. T. and Kisliuk, R. L. Design, Synthesis and Evaluation of Novel 5-Substituted, 2,4-Diaminofuro[2,3-d]pyrimidines as Single Agent Multireceptor Tyrosine Kinase and Dihydrofolate Reductase Inhibitors. Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006. MEDI 141.

Gangjee, A.; Lin, L.; Ihnat, M.; Warnke, L. A.; Thorpe, J. E. and Kisliuk, R. L. Novel-5-Substituted 2,4-diaminofuro[2,3-d]pyrimidines as Potential Multi-receptor Tyrosine Kinases and Dihydrofolate Reductase Inhibitors in Single Molecules. Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006. MEDI 139.

Gangjee, A.; Lin, X.; Biondo, L. R. and Queener, S. F. Design and Synthesis of a Novel Nanomolar Inhibitor of Toxoplasma gondii Dihydrofolate Reductase, Its Salt Form and Analogues. Presented at the 232nd American Chemical Society National Meeting, San Francisco, CA, September 10-14, 2006. MEDI 363.

Gangjee, A.; Namjoshi, O. A.; Ihnat, M. A. and Miller, W. T. Effect of a 2-Amino Group on Receptor Tyrosine Kinase Inhibition and Antiangiogenic Activity of 4-Anilinosubstituted Pyrrolo[2,3-d]pyrimidines. Presented at the 39th Annual Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry (MAGSS) at Ohio State University, Columbus, OH, June 18-20, 2006.

Gangjee, A.; Raghavan, S. and Ihnat, M. A. Synthesis of 2-Amino-4-substituted-6-arylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor tyrosine Kinases. Presented at the 39th Annual Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry (MAGSS) at Ohio State University, Columbus, OH, June 18-20, 2006.

Celikkaya, H.; Jain, H. D.; Zeng, Y.; Yang, J.; Lin, X.; Gangjee, A.; Bertino, J. R. and Abali, E. E. Novel Antifolates That Do Not Upregulate Thymidylate Synthase and Dihydrofolate Reductase Levels. Presented at the 97th American Association for Cancer Research (AACR) Annual Meeting, Washington, DC, April 1-5, 2006. Poster No. 552.

Gangjee, A.; Namjoshi, O. A.; Ihnat, M. A. and Miller, W. T. Effect of a 2-Amino Group on Receptor Tyrosine Kinase Inhibition and Antiangiogenic Activity of 4-Anilinosubstituted Pyrrolo[2,3-d]pyrimidines. Presented at the 97th American Association for Cancer Research (AACR) Annual Meeting, Washington, DC, April 1-5, 2006. Poster No. 243.

Gangjee, A.; Zaware, N.; Yang, J. and Ihnat, M. A. 7-Arylmethyl Pyrrolo[2,3-d]pyrimidines as Receptor Tyrosine Kinase Inhibitors: Design, Synthesis and Biological Evaluation. Presented at the 97th American Association for Cancer Research (AACR) Annual Meeting, Washington, DC, April 1-5, 2006. Poster No. 5077.

Gangjee, A.; Jain, H. D.; Queener, S. F. and Kisliuk, R. L. Non-classical 5-Alkyl-6-substitutedarylthiopyrrolo[2,3-d]pyrimidines as Potent and Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors. Presented at the 231st American Chemical Society (ACS) National Meeting, Atlanta, GA, March 26-30, 2006.

Gangjee, A.; Raghavan, S. and Ihnat, M. A. Synthesis of 2-Amino-4-substituted-6-arylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases. Presented at the 231st American Chemical Society (ACS) National Meeting, Atlanta, GA, March 26-30, 2006.

Gangjee, A. and Lin, X. CoMFA Analysis of tgDHFR and rlDHFR Based on Antifolates with 6-5 Fused Ring System. Presented at the 231st American Chemical Society (ACS) National Meeting, Atlanta, GA, March 26-30, 2006.

Gangjee, A.; Jain, H. D.; Kisliuk, R. L. and Queener, S. F. Design and Synthesis of N-[4-[(2,4-Diamino-5-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-6-ylsulfanyl)-bensoyl]-L-glutamic Acid as a Potent Inhibitor of Dihydrofolate Reductase and as an Antitumor Agent. Presented at the 13th International Symposium on Chemistry and Biology of Pteridienes and Folates, Amsterdam, The Netherlands, June 20-24, 2005. P-09.
Gangjee, A.; Jain, H. D. and Kisliuk, R. L. Synthesis of a Classical N-[4-[(2,6-dimethyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-ylsulfanyl)-benzoyl]-L-glutamic Acid as a Potential Inhibitor of Thymidylate Synthase and Antitumor Agent. Presented at the 13th International Symposium on Chemistry and Biology of Pteridienes and Folates, Amsterdam, The Netherlands, June 20-24, 2005. P-10.

Gangjee, A.; Jain, H. D.; Lin, X.; Zeng, Y.; McGuire, J. J. and Kisliuk, R. L. The Effect of 5-Alkyl Substitution on Dual Inhibitory Activity Against DHFR and TS in Pyrrolo[2,3-d]pyrimidines. Podium presentation at the 13th International Symposium on Chemistry and Biology of Pteridienes and Folates, Amsterdam, The Netherlands, June 20-24, 2005. Abstract number O04-02.

Gangjee, A.; Zhao, Y.; Ihnat, M. A.; Green, D. and Miller, W. T. Synthesis of 2-Amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as Tyrosine Kinase Inhibitors and Antiangiogenic Agents. Presented at the 96th American Association for Cancer Research (AACR) Annual Meeting, Anaheim, CA, April 16-20, 2005.

Gangjee, A.; Kurup, S.; Ihnat, M. A.; Green, D. and Miller, W. T. Synthesis and Biological Activity of 2-Amino-4-substitutedanilino-6-(2,4-dichloro)phenylmethyl-pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases. Presented at the 96th American Association for Cancer Research (AACR) Annual Meeting, Anaheim, CA, April 16-20, 2005.

Gangjee, A.; Ye, Z.; Kisliuk, R. L. and Queener, S. F. Synthesis and Design of 2,4-Diamino-6-substituted-pyrido[3,2-d]pyrimidines as Dihydrofolate Reductase Inhibitors from Opportunistic Pathogens. Presented at the 229th American Chemical Society National Meeting, San Diego, CA, March 13-17, 2005. MEDI 353.
Gangjee, A.; Li, W.; Ihnat, M. A.; Green, D.; Kisliuk, R. L. and Miller, W. T. Novel 5-Substituted, 2,4-Diaminofuro[2,3-d]pyrimidines as Potential Multi-receptors Tyrosine Kinase and Dihydrofolate Reductase Inhibitors. Presented at the 229th American Chemical Society National Meeting, San Diego, CA, March 13-17, 2005. MEDI 112.

Gangjee, A.; Namjoshi, O. A.; Ihnat, M. A.; Green, D. and Miller, W. T. Design, Synthesis and Biological Activities of 2-Amino-4-anilino Substituted-6-arylethyl Pyrrolo[2,3-d]pyrimidines as Receptor Tyrosine Kinase Inhibitors and Antiangiogenic Agents. Presented at the 229th American Chemical Society National Meeting, San Diego, CA, March 13-17, 2005. MEDI 114.

Gangjee, A.; Zaware, N.; Ihnat, M. A.; Green, D. and Miller, W. T. Novel 2-Amino-4-anilino Substituted-7-arylmethyl Pyrrolo[2,3-d]pyrimidines as Receptor Tyrosiine Kinase Inhibitors and Antiangiogenic Agents. Presented at the 229th American Chemical Society National Meeting, San Diego, CA, March 13-17, 2005. MEDI 115.

Gangjee, A.; Jain, H.; Queener, S. F. and Kisliuk, R. L. Design and Synthesis of N-[4-(2,4-diamino-5-propyl-7H-pyrrolo[2,3-d]pyrimidin-6-ylsulfanyl)-benzoyl]-L-glutamic Acid as a Potent Inhibitor of Dihydrofolate Reductase and as an Antitumor Agent. Presented at the 229th American Chemical Society National Meeting, San Diego, CA, March 13-17, 2005. MEDI 491.

Gangjee, A.; Jain, H. D.; Queener, S. F. and Kisliuk, R. L. Design and Synthesis of N-[4-[(2,4-diamino-5-methylfuro[2,3-d]pyrimidin-6-yl)thio]benzoyl]-L-glutamic Acid as a Classical Dual Inhibitor of TS and DHFR. Presented at the 228th American Chemical Society National Meeting, Philadelphia, PA, August 22-26, 2004.

Gangjee, A. and Lin, X. CoMFA and CoMSIA Analyses of Pneumocystis carinii, Toxoplasma gondii and Rat Liver Dihydrofolate Reductase (DHFR) Inhibitors. Presented at the 228th American Chemical Society National Meeting, Philadelphia, PA, August 22-26, 2004.

Gangjee, A.; Qiu, Y. and Ihnat, M. A. Design and Synthesis of 2-Amino-4-(3-bromoanilino)-6-substituted Benzylthieno[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases. Presented at the 228th American Chemical Society National Meeting, Philadelphia, PA, August 22-26, 2004.
Gangjee, A.; Kurup, S.; Ihnat, M. A. and Williams, D. E. Design, Synthesis and Biological Evaluation of 2-Amino-4-substituted Anilino-6-substituted Phenylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases. Presented at the 37th Annual Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry, Purdue University, West Lafayette, IN. June 17-19, 2004.

Gangjee, A.; Qiu, Y. and Kisliuk, R. L. Design and Synthesis of N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-gluatmic Acid as a Classical Thymidylate Synthase Inhibitor and as an Antitumor Agent. Presented at the 37th Annual Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry, Purdue University, West Lafayette, IN. June 17-19, 2004.

Gangjee, A. Antitumor Agents: Design and Synthesis. Presented at the Tripartite Symposium at Duquesne University, sponsored by the Society for Analytical Chemists of Pittsburgh, the Spectroscopy Society of Pittsburgh and the American Chemical Society, Pittsburgh, PA, Apr. 3, 2004.

Gangjee, A.; Jain, H. D.; McGuire, J. J.; Chu, E. and Kisliuk, R. L. Design and Synthesis of Classical and Nonclassical 6-Ethyl-5-arylthio-substituted Pyrrolo[2,3-d]pyrimidines as Inhibitors of Thymidylate Synthase and as Antitumor Agents. Presented at the 227th American Chemical Society National Meeting, Anaheim, CA, Mar. 28 - Apr.1, 2004.

Gangjee, A.; Namjoshi, O. A.; Ihnat, M. A. and Kamat, S. Design and Synthesis of 2-Amino-4-anilino Substituted -6-phenylethylpyrrolo[2,3-d]pyrimidines as Receptor Tyrosine Kinase Inhibitors. Presented at the 227th American Chemical Society National Meeting, Anaheim, CA, Mar. 28 - Apr.1, 2004.

Gangjee, A.; Kurup, S.; Ihnat, M. A. and Williams, D. E. Synthesis and Biological Activity of 2-Amino-4-substituted Anilino-6-substituted Phenylmethyl Pyrrolo[2,3-d]pyrimidines as Inhibitors of Receptor Tyrosine Kinases. Presented at the 95th American Association for Cancer Research Annual Meeting, Orlando, FL, Mar. 27-31, 2004.
Gangjee, A.; Qiu, Y. and Kisliuk, R. L. Design and Synthesis of N-[4-[(2-Amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic Acid as a Classical Thymidylate Synthase Inhibitor and as an Antitumor Agent. Presented at the 95th American Association for Cancer Research Annual Meeting, Orlando, FL, Mar. 27-31, 2004.
Gangjee, A. Design of Single Molecules With Multimechanisms of Action. Presented at the Spring 2004 Seminar, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA , Feb. 24, 2004.

Professional Affiliations

Rho Chi, Pharmacy Honor Society
Phi Lambda Upsilon, Chemistry Honor Society
American Association of Pharmaceutical Scientists
American Chemical Society, Division of Medicinal Chemistry
American Chemical Society, Division of Organic Chemistry
American Chemical Society
Sigma XI, the Scientific Research Society (President,Duquesne University, 1983)
New York Academy of Sciences
American Men and Women of Science
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American Association for the Advancement of Science

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