Division of Pharmaceutical Sciences

Faculty

Lauren O'Donnell, Ph.D. Assistant Professor of Pharmacology Office: 441 Mellon Hall Laboratory: 414 Mellon Hall T 412.396.5133 odonnel6@duq.edu

Educational Background

B.S. – (Animal Science/Agricultural Biotechnology) University of Delaware, Advisor: Carl J. Schmidt, PhD
Ph.D. – (Cell and Molecular Biology) University of Pennsylvania School of Medicine, Advisor: Dennis L. Kolson, MD, PhD
Postdoctoral Fellow – Fox Chase Cancer Center, Advisor: Glenn F. Rall, PhD

Research Interests

• Viral infections of the central nervous system
• Impact of inflammation and infection on the developing brain
• Protective strategies against neuroinflammation

Scientific/Professional Affiliations

• American Society of Virology
• American Society for Microbiology
• International Society of Neurovirology
• Society for Neuroscience

Publications

• O'Donnell LA, Conway S, Rose RW, Nicolas E, Slifker M, Balachandran S, Rall GF. 2012. STAT1-Independent Control of a Neurotropic Measles Virus Challenge in Primary Neurons and Infected Mice. Journal of Immunology. 188(4):1915-23.
  

• O’Donnell, LA, and Rall, GF. 2010. Blue Moon Neurovirology: The Merits of Studying Rare CNS Diseases of Viral Origin. Journal of Neuroimmune Pharmacology. 5(3):443-55.

• O’Donnell, LA, Agrawal, A, Sabnekar, P, Dichter, MA, Lynch, DR, Kolson DL. 2007. Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury. Journal of Neurochemistry. 102(6):1905-17

• Wan, Q, Douglas, SD, Wang, X, Kolson, DL, O’Donnell, LA, Ho, WZ. 2006. Morphine Up-regulates Functional Expression of Neurokinin-1Receptor in Neurons. Journal of Neuroscience Research. 84(7): 1588-1596

• O’Donnell, LA, Agrawal, A, Jordan-Sciutto, KL, Dichter, MA, Lynch, DR, Kolson, DL. 2006. HIV-induced neurotoxicity: Roles for activation of N-Methyl-D-Aspartate receptor subtypes 2A and 2B and the calcium activated protease calpain by a cerebrospinal fluid-derived HIV-1 strain. Journal of Neuroscience; 26(3): 981-90

• O'Donnell, LA, Clemmer, JA, Czymmek, K, Schmidt, CJ. 2002. Marek's disease virus VP22: subcellular localization and characterization of carboxyl terminal deletion Mutations. Virology; 292(2): 235-40

Awards

• 2008-2010 - NIH Ruth L. Kirschstein National Research Service Award for Postdoctoral Fellows (F32 NS062519-01) for “Mechanisms of cytokine-mediated viral clearance from neurons”

• 2009 - Edward Lustbader Award for First Place Oral Presentation – 14th Annual Fox Chase Cancer Center Postdoctoral Research Conference

• 2007-2008 - Fox Chase Cancer Center NIH Training Grant

• 2007 - American Society for Microbiology Annual Philadelphia Infection and Immunity Forum: Best Poster Presentation

• 2006-2007 - Greenwald Fellowship (Fox Chase Cancer Center)

• 2005 - Penn Center for AIDS Research Best Poster Abstract in HIV Pathogenesis

• 2003-2005 - University of Pennsylvania NIH Training Grant in HIV Pathogenesis (T32-AI-007632)

• 2000-2002 University of Pennsylvania Cell and Molecular Biology Training Grant

• 2000 - State of Delaware Center for Agricultural Biotechnology Fellowship

• 1999-2000 - American Society of Animal Science Award

• 1999 - University of Delaware Science and Engineering Research Fellowship

• Alpha Zeta (Agricultural Honor Society) (1997-2000)

Published Abstracts and Presentations

• Invited Speaker: 4th Annual Bice Perussia Memorial Symposium. 2010

• O’Donnell, LA, Rose, RW, Skipworth, JD, Rall, GF. 2009. Interferon signaling in neurons: The usual suspects result in unusual outcomes Gordon Conference: Viruses and Cells.

• Invited speaker: Keystone “Viral Immunity” Workshop; Keystone, CO. 2008

• O’Donnell, LA, Rose, RW, Skipworth, JD, Nicolas, E, Rall, GF. 2007. Interferon-gamma signaling in neurons: Classical pathways or new roads to viral clearance? Gordon Conference: Viruses and Cells.

• O’Donnell, LA, Rose, RW, Skipworth, JD, Nicolas, E, Rall, GF. 2007. Interferon-gamma signaling in neurons: Classical pathways or new roads to viral clearance? 16th Annual Philadelphia Infection and Immunity Forum.

• O’Donnell, LA, Agrawal, A, Sabnekar, P, Dichter, MA, Lynch, DR, Cook, DR, and Kolson, DL. 2007. Apelin, an endogenous soluble neuronal peptide, protects hippocampal neurons against HIV-associated excitotoxic injury. The 8th International Symposium on NeuroVirology.

• O’Donnell, LA, Rose, RW, Skipworth, JD, Nicolas, E, Rall, GF. 2007. Interferon- gamma signaling in neurons: Classical pathways or new roads to viral clearance? Gordon Conference: Viruses and Cells.

• O’Donnell, LA, Rose, RW, Skipworth, JD, Nicolas, E, Rall, GF. 2007. Interferon- gamma signaling in neurons: Classical pathways or new roads to viral clearance? 16th Annual Philadelphia Infection and Immunity Forum.

• O’Donnell, LA, Agrawal, A, Sabnekar, P, Dichter, MA, Lynch, DR, Kolson DL. 2006. The G-protein coupled receptor APJ mediates survival signaling in hippocampal neurons and protects against HIV-induced neurotoxicity. The 7th International Symposium on NeuroVirology.

• White, MG, Kolson, L, Sabnekar, P, Chodroff, RA, O’Donnell, LA, Wang, Y, Akay, A, DL, Jordan-Sciutto, KL. 2006. The role of astrocytes and the integrated stress Response in HIV-infected macrophage induced neurotoxicity. The 7th International Symposium on NeuroVirology.

• O’Donnell, LA, Agrawal, A, Lynch, DR, Dichter, MA, Giudetti, P, Schwarcz, R, Jordan-Sciutto, KL, Kolson, DL. 2005. HIV-Induced Neurodegeneration: Role for the Kynurenine Metabolic Pathway and NMDA Receptor Activation. Society for Neuroscience 35th Annual Meeting.

• O’Donnell, LA, Agrawal, A, Lynch, DR, Dichter, MA, Schwarcz, R, Jordan-Scuitto, KL, Kolson, DL. 2005. HIV-Induced Neurodegeneration: Role for the Kynurenine Metabolic Pathway and NMDA Receptor Activation. Penn Center for AIDS Research 7th Annual Retreat

• O’Donnell, LA, Agrawal, A, Dichter, MA, Lynch, DR, Kolson, DL. 2005 Mechanisms of HIV-induced neurodegeneration: Role of NMDA Receptor Subunits in Communicating Neuronal Cell Death. Conference of Retroviruses and Opportunistic Infections.

• O’Donnell, LA, Dichter, MA, Kolson, DL. 2004. Role of AKT in neuroprotection against HIV-induced apoptosis. American Society for Virology 2004 Annual Meeting.

• O’Donnell, LA, Sabnekar, P, Agrawal, A, Kolson DL. 2004. APJ and Apelin interactions: Downstream effects in primary cortical and hippocampal neurons endogenously expressing APJ. The 6th International Symposium on NeuroVirology.

• O’Donnell, LA, Agrawal, A, Kolson, DL. 2003. APJ/Apelin Signal Transduction is Neuroprotective Against HIV-induced Apoptosis: Examinations using the Human NT2.N Neuronal System. Conference on Retroviruses and Opportunistic Infections.

• O’Donnell, LA, Sabnekar, P, Agrawal, A, Kolson, DL. 2003. Single-cell RNA Profiling of TUNEL reactive neurons in AIDS dementia. The 5th International Symposium on NeuroVirology and the HIV Molecular & Clinical NeuroScience Workshop

• O’Donnell, LA, Chen, W, Sulcove, J, Agrawal, A, Kolson, DL. 2002. Potential neuroprotective role of APJ/Apelin interactions: Protection against HIV-induced apoptosis. Conference on Viral and Host Genetic Factors Regulating HIV/CNS Disease.

• Chen, W, O’Donnell, LA, Frank, I, Ozdener, H, Kolson, DL. 2002. HIV-1 induced neuronal apoptosis: mechanisms, pathways, and production. 4th International Symposium on Neurovirology.