Publications

Peer Reviewed Publications

Saleem M, Stevens A, Deal B, Nehl, Janjic J , JA Pollock (2019). Nanomedicine-driven neuropathic pain relief in a rat model is associated with macrophage polarity and mast cell activation. Acta Neuropathologica Communications 7: 108.

Saleem M, Stevens A, Deal B, Liu L, Janjic J, JA Pollock (2019) A new best practice for validating tail vein injections in rat with near infrared labeled agents. JoVE (146), e59295, doi:10.3791/59295.

Kantorski B,  Sanford-Dolly CW, JA Pollock (2019) Backward design as a mobile application development strategy. Educational Tech Research (2019) Dev. 67: 711. On-line April 8, 2019 67: 711. https://doi.org/10.1007/s11423-019-09662-7

Kassick AJ, Allen HAG, Yerneni SS, Pary F, Kovaliov M, Cheng C, Pravetoni M, Tomycz ND, Whiting DM, Nelson TL, Feasel M, Campbell PG, Kolber BJ, S Averick (2019). Covalent poly(lactic acid) nanoparticles for the sustained delivery of naloxone. ACS Applied Bio Materials 2(8): 3418-3428. doi: 10.1021/acsabm.9b00380.

Tseuguem PP, Ngangoum DAM, Pouadjeu JM, Piégang BN, Sando Z, Kolber BJ, Tidgewell KJ, TB NguelefackC (2019). Aqueous and methanol extracts of Paullinia pinnata L. (Sapindaceae) improve inflammation, pain and histological features in CFA-induced mono-arthritis: Evidence from in vivo and in vitro studies. Journal of Ethnopharmacology 2019 May 23;236:183-195. doi: 10.1016/j.jep.2019.02.048.

Polaski A, Phelps AL, Kostek MC, Szucs KA, & B Kolber (2019). Exercise-induced hypoalgesia: A meta-analysis of exercise dosing for the treatment of chronic pain. PLoS ONE 14(1): e0210418. https://doi.org/10.1371/journal.pone.0210418.

Baktay J, Miller Neilan R, Behun M, McQuaid N, & B Kolber (2019). Modeling neural behavior and pain during bladder distention using an Agent-based model of the central nucleus of the amygdala. SPORA: A Journal of Biomathematics 5(1): 1-13.

Ferraro NA & Cascio M. (2018) Cross-Linking-Mass Spectrometry Studies of Cholesterol Interactions with Human α1 Glycine Receptor. Anal. Chem. 90: 2508-2516. doi: 10.1021/acs.analchem.7b03639.

Lax N, Parker SA, Hilton E, Seliman Y, Tidgewell K, & B Kolber (2018). Cyanobacterial extract with serotonin receptor subtype 7 (5-HT7R) affinity modulates depression and anxiety-like behavior in mice. Synapse Nov;72(11):e22059. doi: 10.1002/syn.22059.

Yarravarapu N, Geffert L, Surratt CK, Cascio M, & DJ Lapinsky (2018) Clickable photoaffinity ligands for the human serotonin transporter based on the selective serotonin reuptake inhibitor (S)-citalopram. Bioorg. Med. Chem. Lett. 28: 3431-3435. doi: 10.1016/j.bmcl.2018.09.029.

Janjic JM, Vasudeva K, Saleem M, Stevens S, Liu L, Patel S, Pollock JA (2018). Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat. Journal of Neuroimmunology, 318, 72-79. https://doi.org/10.1016/j.jneuroim.2018.02.010.

Lampe DJ, Kantorski B, Pollock JA (2018) Charles Darwin Synthetic Interview. Journal of STEM Outreach, [S.l.], v. 1, n. 1, Jan. 2018.

Lax N, Chen R, Leep S, Ulrich K, Yu L, & B Kolber (2017). Polymorphine provides extended analgesic-like effects in mice with spared nerve injury. Molecular Pain 13: 1-12. doi: 10.1177/1744806917743479.

Sadler KE, Gartland N, Cavanaugh J & BJ Kolber (2017). Central amygdala activation of extracellular signal-regulated kinase 1 and age-dependent changes in inflammatory pain sensitivity in mice. Neurobiology of Aging 56: 100-107. doi: http://dx.doi.org/10.1016/j.neurobiolaging.2017.04.010

Beidler E, Donnellan M B, Covassin T, Phelps AL, & Kontos AP (2017). The Association Between Personality Traits and Sport-Related Concussion History in Collegiate Student-Athletes. Sport, Exercise, and Performance Psychology, 6 (3), 252-261, doi: 10.1037/spy0000107

BJ Kolber (2017). It's what's on the inside that counts: Evidence for intracellular GPCR signaling in inflammatory pain. PAIN April 2017 158 (4): 541-542. doi: 10.1097/j.pain.0000000000000843; PMID: 28141636

Sadler KE, McQuaid NA, Cox AC, Behun MN, Trouten AM, & BJ KolberC (2017). Divergent functions of the left and right central amygdala in visceral nociception. PAIN April 2017 158(4): 747-759. doi: 10.1097/j.pain.0000000000000830

Moriarty, J (2016). Seeing Voices: Potential Neuroscience Contributions to a Legal Reconstruction of Insanity. 85 Fordham L. Rev. 599.

Attaallah AF, Elzamzamy OM, Phelps AL, Ranganthan P, & Vallejo MC (2016). Increasing Operating Room Efficiency through Electronic Medical Record Analysis. Journal of Perioperative Practice, 26 (5), 106-108, doi: PubMedID: 27400488.

Provenzano,DA, Deer T, Phelps AL, Drennen Z, Thomson S, Hayek SM, Narouze S, Rana MV, Watson TW, Buvanendran A (2016). An International Survey to Understand Infection Control Practices for Spinal Cord Stimulation. Neuromodulation: Technology at the Neural Interface, 19 (1), doi: 10.1111/ner.12356.

Kostek M, Polaski AG, Kolber B, Ramsey A, Kranjec A & K Szucs (2016). A Protocol of Manual Tests to Measure Sensation and Pain in Humans. J. Vis. Exp. (118), e54130, doi:10.3791/54130 (2016).

Long CC, Sadler KE & BJ Kolber (2016). Hormonal and molecular effects of restraint stress on formalin-induced pain-like behavior in male and female mice. Physiol Behav Oct 165: 278-285. doi: 10.1016/j.physbeh.2016.08.009. PMID: 27520589

Wolz MJ, Sadler KE, Long CC, Brenner D, Kim BS, Gereau IV RW & BJ Kolber (2016). Post-inflammatory hyperpigmentation following human cold pain testing. PAIN Reports 1:e569. doi: 10.1097/PR9.0000000000000569.

Lax N, Ahmed Kh, Ignatz CM, Spadafora C, Kolber BJ & KJ Tidgewell. (2016) Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice. Pharmaceutical Biology Nov;54(11):2723-2731. Epub 2016 May 14 doi: 10.1080/13880209.2016.1181659 PMID: 27181630

Sadler KE, Kolber BJ. (2016) Urine Trouble: Alterations in Brain Function Associated with Bladder Pain. J Urol. 2016 Feb 22.

Provenzano, DA., Deer, TR., Buvanendran, A., Hayek, S., Rana, M., Thomson, S., Narouze, S., Drennen, Z., Watson, T. (2016) An International Survey to Understand Infection Control Practices for Spinal Cord Stimulation. Neuromodulation: Technology at the Interface. Vol. 19. No. 1,:71-84. January 2016. Editor's Choice

Kolber BJ, Janjic JM, Pollock J, K Tidgewell (2016). Summer undergraduate research: A new pipeline for pain clinical practice and research. BMC Med Educ. 2016 May 4;16(1):135.  Link to study data set

Pope, JE., Provenzano, D., McRoberts, P., Deer T. (2016) The Proper Use of Neurostimulation for Hand Pain. Hand Clinics. Vol. 32. No. 1, Feb. 2016.

Provenzano, DA., Williams, JR., Jarzabek, G., DeRiggi, LA., Scott, TF. (2016) Treatment of Neuropathic Pain and Functional Limitations Associated With Multiple Sclerosis Using an MRI-Compatible Spinal Cord Stimulator: A Case Report With Two Year Follow-Up and Literature Review. Neuromodulation: Technology at the Interface. March 2016.

Vasudeva K, Vodovotz Y, Azhar N, Barclay D, Janjic JM, JA Pollock (2015) In Vivo and Systems Biology Studies Implicate IL-18 as a Central Mediator in Chronic Pain. Journal of Neuroimmunology, doi: 10.1016/j.jneuroim.2015.04.012. PMID: 26004155

Provenzano, DA., Watson, TW., Somers, DL. The Interaction Between the Composition of Preinjected Fluids and Duration of Radiofrequency on Lesion Size. Regional Anesthesia and Pain Medicine. Vol. 40. No. 2, March - April 2015.

Narouze, SN., Benzon, HT., Provenzano, DA. Buvanendran, A., De Andres, J., Deer, T., Rauck, R., Huntoon, M. (2015) American Society of Regional Anesthesia and Pain Medicine (ASRA), the European Society of Regional Anesthesia and Pain Therapy (ESRA), the American Academy of Pain Medicine (AAPM), the International Neuromodulation Society (INS), the North American Neuromodulation Society (NANS) and the World Institute of Pain(WIP) Guidelines for Interventional Spine and Pain Procedures in Patients on Antiplatelets and Anticoagulants. Regional Anesthesia and Pain Medicine. Vol. 40. No. 23, May - June 2015.

Ahmed, Kh.T, Lax, N, K Tidgewell (2015) CNS Modulators from the Ocean. In Marine Pharmacognosy: From Beach to Bedside; Ed. Baker, W.; CRC Press.

Provenzano, DA. (2015)Perioperative Precautions for Infection Control. Atlas of Implantable Therapies for Pain Management 2nd Edition. Springer. 2015.

Patel SK, JM Janjic (2015). Macrophage targeted theranostics as personalized nanomedicine strategies for inflammatory diseases. Theranostics ;5:150-72.

Liu L, Bagia C, JM Janjic (2015). The First Scale-Up Production of Theranostic Nanoemulsions. ; Bioresearch Open Access.

Janjic JM, SK Patel (2015). Perfluorocarbon Theranostic Nanomedicines: Pharmaceutical Scientist's Perspective. In: Ahrens ET, Flogel U, editors. 19F Magnetic Resonance Imaging: Pan Stanford Publishing; 2015.

BJ Kolber (2015). mGluRs from head to toe in pain. Prog Mol Biol Transl Sci. 131: 281-324.

JR Covvey (2015). Recent developments toward the safer use of opioids in the USA, with a focus on hydrocodone. Res Social Adm Pharm. Published online 13 Feb.

Pope D, Madura JD, M Cascio (2014) β-Amyloid and neprilysin computational studies identify critical residues implicated in binding specificity. J. Chem. Inf. Model. 54, 1157-65.

Wen Y, Liu W, Bagia C, Zhang S, Bai M, Janjic JM, et al. (2014) Antibody-functionalized peptidic membranes for neutralization of allogeneic skin antigen-presenting cells. Acta Biomaterialia.

Liu, Z, Szarecka, A, Yonkunas, M, Speranskiy, K, Kurnikova, M, and M Cascio (2014) Crosslinking constraints and computational models as complementary tools in modeling the extracellular domain of the glycine receptor. PLoS One. 9, e102571.

Lobo, C, Pfalzgraf, A, Giannetti, V, and G Kanyongo (2014). Impact of invalidation and trust in physicians on health outcomes in fibromyalgia patients. J ClinPsychiat-PCC CNS Disord. (In Press).

Lax N, George D, Ignatz C and B Kolber (2014). The mGluR5 Antagonist Fenobam Induces Analgesic Conditioned Place Preference in Mice with Spared Nerve Injury.  PLoS One. 2014 Jul 25;9(7):e103524.

Nolan T, Geffert L, Kolber B, Madura J and C Surratt (2014). Discovery of Novel-Scaffold Monoamine Transporter Ligands via in Silico Screening with the S1 Pocket of the Serotonin Transporter. ACS Chem Neurosci. 2014 Jul 15.

Sadler K, Stratton J and B Kolber (2014). Urinary bladder distention evoked visceromotor responses as a model for bladder pain in mice. Journal of Visual Experimentation 2014 Apr 27;(86).

Janjic J, Pin S, Patel S, Zhang S, Yang X and M Bai (2014). Design and Development of Fluorinated Nanoemulsions with Optimal Fluorescent, Colloidal and Magnetic Properties for Bimodal Imaging. Biomaterials (2014)  (In Press).

Mountain G, Bagia C, Jelier B, Friesen C and J Janjic (2014). Design and formulation of nanoemulsions using 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro(polyethylene glycol dimethyl ether) Journal of Fluorine Chemistry 2014 Jun 1;162:38-44.

Vasudeva K, Andersen K, Zeyzus-Johns B, Hitchens T, Patel S, Balducci A, Janjic J and J Pollock (2014). Imaging neuroinflammaiton in-vivo in a neuropathic pain rat model with near-infrared fluorescence and 19F magnetic resonance. PLoS ONE 9 (2): e90589.

Sadler K, Stratton J, DeBerry J and B Kolber (2013).Optimization of a pain model: effects of body temperature and anesthesia on bladder nociception in mice. PLoS ONE Nov 5; 8(11): e79617.

Lobo C, Pfalzgraf A, Giannetti V. Self-reported quality of life, treatment effectiveness, attitudes and perceptions of fibromyalgia patients. Journal of Pharmacy Practice. 2013;26(3):304-346.

Janjic J, Patela S, Patrick M,  Pollock J, DiVito E and M Cascio (2013) Suppressing inflammation from inside out with novel NIR visible perfluorocarbon nanotheranostics. Proc. SPIE 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 85960L (February 21, 2013); doi:10.1117/12.2004625.

Patel SK, Zhang Y, Pollock JA, and Janjic JM (2013) Cyclooxgenase-2 inhibiting perfluoropoly (ethylene glycol) ether theranostic nanoemulsion - In vitro study.  PLoS ONE 8(2): e55802. doi:10.1371/journal.pone.0055802

Balducci A, Wen Y, Zhang Y, Helfer BM, Hitchens TK, Meng WS, Wesa AK, and Janjic J (2013).  A novel probe for the non-invasive detection of tumor-associated inflammation.  Onco Immunology 2(2).  

Crock LW*, Kolber BJ*, Morgan C D, Sadler K E, Vogt SK, Bruchas MR and Gereau RW IV (2012) Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain. The Journal of Neuroscience  32(41):14217-14226.  * co-first authors

Goss JR*, Cascio M*, Goins WF, Huang S, Krisky DM, Clarke RC, Johnson JW, Yoshimura N, Gold MS, Glorioso JC (2011) HSV delivery of a ligand-regulated endogenous ion channel gene to sensory neurons results in pain control following channel activation. Molecular Therapy 19, 500-506. * co-first authors

Lamb K, Tidgewell K, Simpson D, Bohn LM and Prisinzano TE (2011) Effects of Herkinorin, a Novel mu Opioid Receptor Agonist Derived from Salvinorin A, on Nociception in Rats. Drug Alcohol Depend 121(3) 181-8.

Montana MC, Conrardy BA, Cavallone LF, Kolber BJ, Rao LK, Greco SC, RW Gereau (2011) Metabotropic Glutamate Receptor 5 Antagonism with Fenobam: Examination of Analgesic Tolerance and Side Effect Profile in Mice. Anesthesiology 115(6):1239-1250.

Nolan TL, Lapinsky DJ, Talbot JN, Indarte M, Liu Y, Manepalli S, Geffert LM, Amos ME, Taylor PN, Madura JD, Surratt CK (2011) Identification of a novel selective serotonin reuptake inhibitor by coupling monoamine transporter-based virtual screening and rational molecular hybridization.  ACS Chem Neurosci 2:544-552.

Manepalli S, Geffert LM, Surratt CK and Madura JD (2011) Discovery of novel selective serotonin reuptake inhibitors through development of a protein-based pharmacophore. J Chem Inf Model 51:2417-2426.

Arnett MG, Kolber BJ, Boyle MP, & Muglia LJ (2011) Behavioral insights from mouse models of forebrain--and amygdala-specific glucocorticoid receptor genetic disruption.  Molecular and cellular endocrinology 336(1-2):2-5.

Kolber BJ, Montana MC, Carrasquillo Y, Xu J, Heinemann SF, Muglia LJ & RW Gereau   (2010) Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. J Neurosci 30(24):8203-8213.

Provenzano A, Lassila HC and Somers DL (2010) The effect of fluid injection on lesion size during radiofrequency treatment period.  Regional Anesthesia and Pain Medicine, 35: 338-342.

Indarte M, Liu Y, Madura JD and Surratt CK (2010) Receptor-based discovery of a plasmalemmal monoamine transporter inhibitor via high-throughput docking and pharmacophore modeling. ACS Chem Neurosci 1:223-233.

Kolber BJ, Howell MP, Wieczorek L, Kelley CL, Onwuzurike CC, Nettles SA, Vogt SK & LJ Muglia   (2010) Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice.  J Neurosci 30(7):2571-2581.

Somers DL, Clemente FR (2009) Contralateral high or a combination of high and low frequency transcutaneous electrical nerve stimulation reduces mechanical allodynia and alters dorsal horn neurotransmitter content in neuropathic rats. Journal of Pain 10:221-229

Leak RK, Zigmond MJ, and Liou AKF (2008) Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism. Journal of Neurochemistry. 106: 860-874.

Kolber BJ, Roberts MS, Howell MP, Wozniak DF, Sands MS & LJ Muglia   (2008) Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning.  PNAS 105(33):12004-12009.

Tidgewell K, Groer C, Harding WW, Lozama A, Schmidt M, Marquam A, Hiemstra J, Partilla JS, Dersch CM, Rothman RB, Bohn LM and Prisinzano T (2008) Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem 51(8): 2421-2431.

Holden K, Tidgewell K, Marquam A, Rothman RB, Navarro H, and Prisinzano T (2007) Synthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-position. Bio. Med. Chem. Letters. (17): 6111-6115.

O'Donnell LA, Agrawal A, Sabnekar P, Dichter MA, Lynch DR, Kolson DL (2007) Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury. J Neurochem 102(6):1905-1917.

Groer C, Tidgewell K, Moyer R, Harding W, Rothman R, Prisinzano T, and Bohn L (2007) An Opioid Agonist that Does Not Induce Mu Opioid Receptor - Arrestin Interactions or Receptor Internalization. Mol Pharm. (71): 549-557.

O'Donnell LA, Agrawal A, Jordan-Sciutto KL, Dichter MA, Lynch DR, Kolson DL. (2006) Human Immunodeficiency Virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes. J Neurosci 26(3): 981-990.

Somers DL, Clemente FR (2006) Transcutaneous electrical nerve stimulation for the treatment of neuropathic pain: the impact of frequency and electrode position on prevention of allodynia in a rat model of complex regional pain syndrome type II Physical Therapy 86:698-709.

Leak RK, Liou KF, and Zigmond MJ (2006) Effects of sublethal 6-hydroxydopamine on the response to subsequent oxidative stress in dopaminergic cells: evidence for preconditioning.Journal of Neurochemistry. 99: 1151-1163

Tidgewell K, Harding W, Schmidt M, Lozama A, Cobb H, Shah K, Kannan P, Dersch C, Parrish D, Deschamps J, Rothman R and Prisinzano T (2006) Synthesis of Salvinorin A Analogues as Opioid Receptor Probes. J.Nat.Prod. (69): 914-918.

Surratt CK, Ukairo OT and Ramanujapuram S (2005) Recognition of psychostimulants, antidepressants and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transporters. Am Assoc Pharmaceu Sci J 7:Article 74.

Surratt CK and Adams WR (2005) G protein-coupled receptor structural motifs and their application to opioid receptor activation. Curr Topics Med Chem 5:315-324.

Harding WW, Tidgewell K, Schmidt M, Shah K, Dersch CM, Snyder J, Parrish D, Deschamps J, Rothman R and Prisinzano TE(2005) Salvinicins A and B, New Neoclerodane Diterpenes from Salvia divinorum. Org. Lett.  (7): 3017-3020.

Spivak CE, Beglan CL, Zöllner C and Surratt CK (2003) b-Funaltrexamine, a gauge for the recognition site of wild-type and mutant H297Q -opioid receptors. Synapse 49:55-60.

Somers DL, Clemente FR (2003) The relationship between dorsal horn neurotransmitter content and allodynia in neuropathic rats treated with high frequency transcutaneous electrical nerve stimulation Archives of Physical Medicine and Rehabilitation 84:1575-1583.

Somers DL and Clemente FR (2002) Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve Neuroscience Letters 323: 171-174.

Wang D, Surratt CK and Sadee W (2000) Calmodulin regulation of basal and agonist-stimulated G protein coupling by the  opioid receptor (OP3) in morphine pretreated cells. J Neurochem 75:763-771.

Deng HB, Yu Y, Pak Y, O'Dowd BF, George SR, Surratt CK, Uhl GR, Wang JB (2000) Role for the C-terminus in agonist-induced  opioid receptor phosphorylation and desensitization. Biochemistry 39:5492-5499.Zöllner C, Johnson PS, Bei Wang J, Roy AJ Jr, Layton KM, Min Wu J, Surratt CK. (2000) Control of  opioid receptor expression by modification of cDNA 5'- and 3'-noncoding regions. Brain Res Mol Brain Res 79:159-162.

Zhang P, Johnson PS, Zöllner C, Wang W, Wang Z, Montes AE, Seidleck BK, Blaschak CJ, Surratt CK (1999) Mutation of human  opioid receptor extracellular "disulfide cysteine" residues alters ligand binding but does not prevent receptor targeting to the cell plasma membrane. Brain Res Mol Brain Res 72:195-204.

Somers DL, Somers MF (1999) Treatment of neuropathic pain in a patient with diabetic neuropathy using transcutaneous electrical nerve stimulation applied to the skin of the lumbar region Physical Therapy 79 (8): 767-775.

Makman MH, Dobrenis K and Surratt CK (1998) Properties of mu3 opiate alkaloid receptors in macrophages, astrocytes, and HL-60 human promyelocytic leukemia cells. Adv Exp Med Biol 437:137-148.

Somers DL, Clemente FR (1998) High frequency transcutaneous electrical nerve stimulation (TENS) alters thermal but not mechanical allodynia following chronic constriction injury of the rat sciatic nerve, Archives of Physical Medicine and Rehabilitation 79:1370-1376.

Spivak CE, Beglan CL, Seidleck BK, Hirshbein LD, Blaschak CJ, Uhl GR, Surratt CK.(1997) Naloxone activation of  opioid receptors mutated at a histidine residue lining the opioid binding cavity. Mol Pharmacol 52:983-992.

Gillo B, Chorna I, Cohen H, Cook B, Manistersky I, Devary O, Arnon A, Baumann A, Kaupp UB, Pollock J, Selinger Z, B. Minke (1996) Co-expression of Drosophila TRP and TRPL in Xenopus oocytes reconstitutes a capacitative Ca2+ entry similar to the light-activated conductance. Proceedings of the National Academy of Science USA 93, 14146-14151.

Somers DL, Clemente FR (1996) The neurophysiological basis of peripheral electrical nerve stimulation for the treatment of causalgia Physical Therapy Reviews. 1:1-12.

Uhl GR, et al. (1995) Opiate receptor: expression, transgenic mice, and influences of C-terminal and 3'-untranslated regions. Analgesia 1:801-804.

Surratt, CK, et al. (1994) Opiate receptor structure/function relationships. Regulatory Peptides 54:289-290.

Surratt CK, Johnson PS, Moriwaki A, Seidleck BK, Blaschak CJ, Wang JB, Uhl GR (1994) Opiate receptor: charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity. J Biol Chem 269:20548-20553.