Jelena M. Janjic

Associate Professor
School of Pharmacy
Graduate School of Pharmaceutical Sciences

Mellon Hall 415
Phone: 412.396.6369
janjicj@duq.edu
http://www.painnanomedicine.org

Education:

Ph.D., Medicinal Chemistry, University of Pittsburgh, 2005
Diplomirani Farmaceut, Belgrade University, 1998
Expertise & Background

Dr. J's experstise includes:

  • Design and synthesis of novel drug delivery formulations with focus on liquid and semisolid dosage forms and nanosystems
  • Design, synthesis, and biological evaluation of theranostic dosage forms (nanoemulsions, nanogels, gels, capsules, etc.) for imaging and treatment of inflammation in varied pathological states (cancer, neuronal injury, inflammatory bowel disease, muscle diseases)
  • Applying theranostics and nanotechnology to studying immune system and nervous system interplay in chronic pain
  • Development of nanotechnology based therapeutic interventions for chronic pain.

Background

Chronic Pain Research Consortium (CPRC), Duquesne University, Pittsburgh, PA
Founder & Co-Director, May 2011–Present

The CPRC takes an integrated and multidisciplinary approach to the study of all aspects of chronic pain. . Consortium members are faculty across the Duquesne University campus, representing expertise in neuroscience, biology, pharmacy, nursing, physical therapy, molecular biology, biochemistry, medicinal chemistry, neuropharmacology, molecular imaging, and psychology. Consortium has to date obtained more than 5 million dollars in external funding for research and education with members serving as PIs and/or Co-Is. CPRC held 5 research retreats, regular bimonthly journal club since 2012, and hosted several distinguished speakers in the field. The Consortium has become a locally and nationally recognized group for interdisciplinary and holistic research of pain and chronic pain in varied disciplines, from neuroscience, to education and nanotechnology. It continues to foster and support projects with unique partnerships between health practitioners and scientists.

Duquesne University School of Pharmacy and Graduate School of Pharmaceutical Sciences, Pittsburgh, PA
Associate Professor of Pharmaceutics (Tenured), July 2009–Present

  • Mentor and train students (PhD, MS, PharmD, undergraduate) in drug formulation design, molecular imaging, nanotechnology and pharmaceutics in a laboratory setting
  • Direct MS/PhD research theses
  • Design and synthesize novel drug delivery agents
  • Design, synthesize and biologically evaluate theranostic dosage forms (nanoemulsions, nanogels, gels, capsules) for imaging and treatment of inflammatory diseases and disorders (IBD, cancer, neuroinflammation, muscle diseases)
  • Study tumor inflammation using natural products and molecular imaging
  • Study interplay of immune and nervous systems in chronic pain animal models
  • Design, development and manufacturing of first examples of pain nanomedicines.

AIRMED Program, 59th Medical Wing United States Airforce, USAISR, San Antonio, TX
ORISE Faculty Fellow, Principal Scientist, July 2018–Present

  • Advise, mentor and train surgical residents and medical fellows at the USAISR
  • Direct research on design and development of nanomedicine for the medical needs of the warfighter and their families
  • Post-trauma and surgical pain therapeutic development
  • Nanomedicine applied to post-surgical care, transplantation and organ preservation in combat casualty care scenarios
  • Coordinate collaborative research between AIRMED program and academic groups.

McGowan Research Institute for Regenerative Medicine, Pittsburgh, PA
Faculty Member, May 2014–Present

  • Nanotechnology, drug delivery and imaging systems development applied to regenerative medicine
  • Inflammation and pain therapeutic and diagnostic strategies in regeneration, transplantation and surgical recovery
  • Monitoring/treatment of rejection with nanotechnology and localized immunosupression delivery systems.

Duquesne University School of Pharmacy and Graduate School of Pharmaceutical Sciences, Pittsburgh, PA
Assistant Professor of PharmaceuticsJuly 2009–June 2015

Carnegie Mellon University Department of Biological Sciences, Pittsburgh PA
Visiting Scientist, July 2009–Dec. 2011

  • Formulate and assess in vitro multimodal biosensor /19F MRI reagents for tracking therapeutic cells and immunotherapy

Celsense Inc., Pittsburgh, PA
Director of Pharmaceutical Chemistry, Oct. 2008–July 2009

  • Designed, synthesized and formulated the first Phase I clinical 19F MRI reagent for monitoring immunotherapeutic cells in humans
  • Designed and formulated preclinical grade 19F MRI reagents for quantification of inflammation
  • Transferred technology from academic to industrial laboratories 
  • Coordinated team efforts in producing MRI reagents for pre-clinical and clinical use
  • Coordinated team efforts in analytical chemistry development for evaluating MRI reagents
  • Consulted on biological in vitro assay development for testing MRI reagents 
  • Trained formulation scientists in microfluidization nanoreagent production

Celsense Inc., Pittsburgh, PA
Senior Research Scientist, 2006-08

  • Designed, synthesized, formulated and biologically evaluated novel MRI reagents
  • Designed and formulated several novel MRI reagents currently under development towards commercialization
  • Developed analytical assay for MRI reagents
  • Processed data and evaluated protocol for scale up, analysis and follow up of novel MRI reagents produced in industrial setting
  • Trained research biologists in evaluation of MRI reagents

Carnegie Mellon University Department of Biological Sciences, Pittsburgh PA
Research Biologist (Special Faculty), 2006-09

  • Designed, synthesized and formulated novel in vivo MRI contrast reagents and tracers for in vivo cell tracking
  • Designed, synthesized and formulated the first dual fluorescence/19F MRI reagents
  • Developed assays for in vitro evaluation of MRI tracers (19F NMR, cell based assays, fluorescence imaging, biochemical techniques, confocal microscopy)
  • Coordinated and/or directed grant writing, project development, and research efforts of graduate students, staff and external collaborators

The Scripps Research Institute, Jupiter, FL
Research Associate, 2005-06

  • Developed HTS cell-based assays for large compound, DNA and RNA collection screens targeting cancer and inflammation pathways
  • Screened focused small molecule libraries (>1000 members)
  • Screened focused DNA library (>1000 members)

University of Pittsburgh School of Pharmacy, Pittsburgh, PA
Graduate Student Research/Teaching Fellow, 2002-05

  • Conducted microwave chemistry
  • Conducted medicinal chemistry (small molecule synthesis, analog design, SAR, protein-ligand interactions, computational modeling)
  • Conducted cell-based assays (cell-based screening studies, luminescence assays, protein expression, cell transformation via plasmid transfection)
  • Conducted fluorescence-polarization assays for in vitro drug screening
  • Trained undergraduate researchers in microwave chemistry, cell-based assays and data analysis

University of Pittsburgh Cancer Institute, Pittsburgh, PA
Research Specialist, 2000-01

  • Conducted flow cytometry, ELISA, western blot and cell culture cytoxicity assays
  • Conducted cancer cell biology research

Pharmacy "Labud", Belgrade, SR Yugoslavia
Pharmacist, 1999-00

  • Compounded pharmaceutical and cosmetic preparations
  • Developed cosmetics products
  • Retail pharmacy and patient counseling

National Reserves of Republic of Serbia, SR Yugoslavia
Pharmacist Administrator, 1998-99

  • Managed medical supplies, prescription and over-the-counter medications in national reserves
Awards & Recognition

Awards & Recognition

2019 Defense Tech Connect Innovator Award Challenge – Oct 8, 2019, National Harbor, Washington DC
2018 Pittsburgh Business Times 2018 Innovator Award
2018 Inducted into Duquesne University Research Hall of Fame
2018 Faculty Award, School of Pharmacy, Duquesne University, for excellence in teaching, scholarship and service
2018 Nomination for the President's Award of Excellence in Service to the Mission of Duquesne University, nominated by the School of Pharmacy, Duquesne University
2018 Selected to represent Duquesne University at 2018 Collegium at the College of the Holy Cross, June 2018
2013 Faculty Member of The Rho Chi Society, The Academic Honor Society in Pharmacy
2013 Wakonse Fellow, selected by Center of Teaching Excellence (Duquesne University) to present at and attend Wakonse Teaching Conference
2004 Graduate Student Excellence Award, School of Pharmacy, Univ. of Pittsburgh, Pittsburgh, PA
2004 National Medicinal Chemistry Symposia Travel Award, Madison, WI
2001 JHF-CORO Health Sciences Fellowship, Pittsburgh, PA

Recognition In Public Media

2019 TEDxCMU Invited Speaker for "Ripple Effect" Main Conference, March 30, 2019
2019 Article in Duquesne Times on USAF Visit
2018 Duquesne times article on Innovator 2018 Award
2018 Interview with Joe Palca, NPR
2018 Highlights From the American Pain Society Scientific Summit: Can Nanomedicine Play a Role in the Future of Pain Treatment? A session at the March 4-6, 2018, event featured animal studies on macrophage-targeted nanomedicine by Ashley Cowie on 29 May 2018
2018 Interview for WTAE (Channel 4 News)
2018 "Duquesne Researchers Working On Drug That Could Be Upgrade To Current Anti-Inflammatories" By JOAQUIN GONZALEZ • APR 3, 2018 NPR, WESA interview
2017 Interview for the podcast Regenerative Medicine Today - Janjic - Podcast #167
2014 "Duquesne Professors Collaborate To Pioneer Research On Chronic Pain" September 23rd, 2014
Duquesne University Magazine, Fall 2014
2014 "Where Does It Hurt? New Processes Development by Duquesne's Chronic Pain Consortium Could Provide the Answer" April 16, 2014, Duquesne University News
2014 "Got Collaboration? New Provost Award Encourages Interdisciplinary Research" Duquesne University Times April 9, 2014
2012 "Grant Funds Chronic Pain Study at Duquesne University", Duquesne University News, February 1, 2012
2012 "University Researchers Collaborate to Study Chronic Pain" in The Chronicle, a quarterly newsletter published by American Chronic Pain Association, March 2012
2011 "Personalizing Nanomedicine", front page featured full article by Lauren K. Wolf , Chemical and Engineering News, 89 (39), pp 29-32, September 26, 2011
2004 Pittsburgh Tribune Review Newsmaker, August 22, 2004
2003 "Winning Combination", full feature article by Kris B. Mamula, PITT Magazine, Summer Issue
2003 "Combinatorial Libraries: Life's Tinker Toys" by By Gail Dutton in The Scientist May 9, 2003

Memberships In Professional Organizations

2017–Present The Transplantation Society
2017–Present International Society of Vascularized Composite Allotransplantation
2014–19 American Pain Society, member (Membership committee member)

2013–Present

The International Society for Optics and Photonics (SPIE)
2013–Present The Association for Contemplative Mind in Higher Education
2011–Present International Association for the Study of PAIN
2009–Present American Association of Colleges of Pharmacy
2008–Present American Chemical Society, Fluorine Division
2002–Present American Association of Pharmaceutical Scientists
2002–04 American Chemical Society, Medicinal Chemistry Division
Scholarship

Peer Reviewed Publications

(*Corresponding author; Chronologically ordered from most recent; Scopus H index = 17, Google Scholar H index = 19)

  1. Stevens AM, Liu L, Bertovich D, Janjic JM, Pollock JA. Differential Expression of Neuroinflammatory mRNAs in the Rat Sciatic Nerve Following Chronic Constriction Injury and Pain-Relieving Nanoemulsion NSAID Delivery to Infiltrating Macrophages. Int J Mol Sci. 2019 Oct 24;20(21). pii: E5269. doi: 10.3390/ijms20215269
  2. E. Lambert, V. Gorantla, J.M. Janjic* "Pharmaceutical Design and Development of Perfluorocarbon Nanocolloids for Oxygen Delivery in Regenerative Medicine" Nanomedicine 2019, Published Online:28 Oct 2019https://doi.org/10.2217/nnm-2019-0260 Part of Special Issue "Nanomedicinein Organ Transplantation and Regenerative Surgery -Advances, Applications, and Future Directions" Nanomedicine, November, 2019, Co-Edited by. V.S. Gorantla and J.M. Janjic
  3. M Saleem, B Deal, E. Nehl, JM Janjic, JA Pollock* "Nanomedicine-driven neuropathic pain relief in a rat model is associated with macrophage polaritry and mast cell activation." Acta Neuropathol Commun. 2019. 7, Article number: 108
  4. M. Herneisey, E.Lambert, A. Kachel, E. Shychuck, J. K. Drennen III and J.M. Janjic* "Quality by Design Approach Using Multiple Linear and Logistic Regression Modeling Enables Microemulsion Scale Up" Molecules 2019, 24(11), 2066; https://doi.org/10.3390/molecules24112066
  5. M Saleem, AM Stevens, B Deal, L Liu, J Janjic, JA Pollock* "A New Best Practice for Validating Tail Vein Injections in Rat with Near-infrared-Labeled Agents." Journal of visualized experiments: JoVE 2019 (146), e59295, doi:10.3791/59295
  6. J. M. Janjic "Inflammation Targeted Nanomedicine: A perspective on the promise and potential of biomedical technologies for pain diagnosis and management." (Invited Article) Practical Pain Management 2019, Vol (19), Issue 1, pages: 33-35
  7. E. Lambert, J.M. Janjic* "Multiple Linear Regression Applied to Predicting Droplet Size of Complex Perfluorocarbon Nanoemulsions for Biomedical Applications" Pharmaceutical Development and Technology 2019, 24, 700-710
  8. M. Herneisey¶, L. Liu¶, E. Lambert, N. Schmitz, S. Loftus, and J.M. Janjic* Development of Theranostic Perfluorocarbon Nanoemulsions as a Model Non-Opioid Pain Nanomedicine Using a Quality by Design (QbD) Approach AAPS PharmSciTech 2019, 20: 65. https://doi.org/10.1208/s12249-018-1287-6
  9. J. M. Janjic* and V.S. Gorantla* "Novel Nanoimaging Strategies for Noninvasive Graft Monitoring in Vascularized Composite Allotransplantation" invited commentary, Current Transplantation Reports 2018, 5 (4), 369-372 https://doi.org/10.1007/s40472-018-0221-x
  10. J. M. Janjic*, K. Vasudeva, M. Saleem, L. Liu, S.K. Patel, A. Stevens, J.A. Pollock* "Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in Rat" Journal of Neuroimmunology 2018, http://www.jni-journal.com/article/S0165-5728(18)30012-2/fulltext (The first Theranostic Pain Nanomedicine)
  11. J. M. Janjic* and V. Gorantla "Clinically translatable nanotheranostic platforms for peripheral nerve regeneration: design with outcome in mind", Proc. SPIE 10508, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X, 1050803 (20 February 2018); doi: 10.1117/12.2289288; https://doi.org/10.1117/12.2289288
  12. J. M. Janjic* and V. Gorantla "Peripheral Nerve Nano-Imaging: Monitoring Treatment and Regeneration" 2017, AAPS J. Sep;19(5), 1304-1316 (invited review)
  13. Herneisey, M., Williams, J., Mirtic, J., Liu, L., Potdar, S., Bagia, C., Cavanaugh, J.E., Janjic, J.M.* Development and characterization of resveratrol nanoemulsions carrying dual-imaging agents Therapeutic Delivery 2016, 7 (12), 795-808
  14. BJ Kolber, JM Janjic, JA Pollock, KJ Tidgewell Summer undergraduate research: A new pipeline for pain clinical practice and research BMC Medical Education 2016 (1), 16:135 DOI: 10.1186/s12909-016-0648-7
  15. Janjic, J.M.*, Berlec, A., Bagia, C., Liu, L.S., Jeric, I., Gach, M., Janjic, B.M., Strukelj, B.NIR and MR imaging supported hydrogel based delivery system for anti-TNF alpha probiotic therapy of IBD (2016) Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9723, art. no. 972309
  16. Liu, L., Bagia, C., Janjic, J.M.* "The First Scale up Production of Theranostic Nanoemulsions" Bioresearch Open Access 2015, 4(1): 218-228. (Invited Paper)
  17. Patel, S.K., Beaino, W., Anderson, C.J., Janjic, J.M.* Theranostic Nanoemulsions for Macrophage COX-2 Inhibition in a Murine Inflammation Model Clinical Immunology 2015, 160, 59-70.
  18. S.K. Patel and J.M. Janjic* "Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases" Theranostics 2015, (2), 150
  19. Vasudeva, K., Vodovotz, Y., Azhar, N., Barclay, D., Janjic, J.M., Pollock, J.A.* "In Vivo and Systems Biology Studies Implicate IL-18 as a Central Mediator in Chronic Pain" Journal of Neuroimmunology 2015, 283, 43-49
  20. Wen, Y., Liu, W., Bagia, C., Zhang, S., Bai, M., Janjic, J.M., Giannoukakis, N., Gawalt, E. S., Meng, W.S.* "Antibody-Functionalized Peptidic Membranes for Neutralization of Allogeneic Skin Antigen-Presenting Cells" Acta Biomaterialia 2014, 10 (11), 4759-4767
  21. Jia, N., Zhang, S., Shao, P., Bagia, C., Janjic, J.M., Ding, Y. and Bai, M.* "Cannabinoid CB2 Receptor as a New Phototherapy Target for Inhibition of Tumor Growth." Molecular Pharmaceutics 2014, 11 (6), 1919-1929
  22. Janjic, J.M.*, Shao, P., Zhang, S., Yang, X., Patel, S.K., Bai, M.* "Perfluorocarbon nanoemulsions with fluorescent, colloidal and magnetic properties" Biomaterials 2014, 35 (18), 4958-4968
  23. Mountain, G.A., Jelier, B.J., Bagia, C., Friesen, C.M., Janjic, J.M.* "Design and formulation of nanoemulsions using 2-(poly (hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro (polyethylene glycol dimethyl ether)"Journal of Fluorine Chemistry 2014, 162, 38-44
  24. K. Vasudeva, K. Andersen, B. Zeyzus-Johns, T.K. Hitchens, S.K. Patel, A. Balducci, J.M. Janjic, J. A. Pollock* "Imaging Neuroinflammation In Vivo in a Neuropathic Pain Rat Model with Near-Infrared Fluorescence and 19F Magnetic Resonance" PloS one 2014, 9 (2), e90589
  25. M.J. Patrick¥, J.M. Janjic¥, H. Teng, M.R. O'Hear, C.W. Brown, J.A. Stokum, B.F. Schmidt, E.T. Ahrens*, A.S. Waggoner "Intracellular pH measurements using perfluorocarbon nanoemulsions" Journal of the American Chemical Society 2013, 135 (49), 18445-18457. (¥Co-first authors)
  26. S.K. Patel, J. Williams, J.M. Janjic* "Cell labeling for 19F MRI: New and Improved Approach to Perfluorocarbon Nanoemulsion Design" Biosensors 2013, 3(3), 341-359 (open access)
  27. S.K. Patel, M.J. Patrick, J.A. Pollock, J.M. Janjic* "Two-color fluorescent (near-infrared and visible) triphasic perfluorocarbon nanoemulsions" Journal of Biomedical Optics 2013, 18 (10), 101312,
  28. J.M. Janjic*, S.K. Patel, M.J. Patrick, J.A. Pollock, E. DiVito, M. Cascio "Suppressing inflammation from inside out with novel NIR visible perfluorocarbon nanotheranostics" (Invited Paper) Progress in Biomedical Optics and Imaging - Proceedings of SPIE 2013, 8596, art. no. 85960L
  29. S.K. Patel, Y. Zhang, J.A. Pollock, J.M. Janjic* "Cyclooxygenase-2 Inhibiting Perfluoropoly (ethylene glycol) ether Theranostic Nanoemulsions - In Vitro Study" PloS one 2013, 8(2):e55802.
  30. A. Balducci, Y. Wen, Y. Zhang, B.M. Helfer, T.K. Hitchens, W.S. Meng, A.K. Wesa, J.M. Janjic*, "A novel probe for the non-invasive detection of tumor-associated inflammation" Oncoimmunology 2013, 2 (2), e23034
  31. C.E. O'Hanlon, K.G. Amede, M.R. O'Hear, J.M. Janjic* "NIR-labeled perfluoropolyether nanoemulsions for drug delivery and imaging" Journal of Fluorine Chemistry 2012, 137, 27-33
  32. T.K. Hitchens, Q. Ye, D.F. Eytan, J.M. Janjic, E.T. Ahrens, C. Ho "19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells" Magnetic Resonance in Medicine 2011, 65, 1144-1153
  33. D.K.K. Kadayakkara, J.M. Janjic, L.K. Pusateri, W.B. Young, E.T. Ahrens "In vivo observation of intracellular oximetry in perfluorocarbon-labeled glioma cells and chemotherapeutic response in the CNS using fluorine-19 MRI" Magnetic Resonance in Medicine 2010, 64,1252-1259
  34. B. Helfer, A. Balducci, A. Nelson, J.M. Janjic, R.R. Gil, P. Kalinski, J. M. de Vries, E.T. Ahrens, R. Mailliard, "Functional assessment of human dendritic cells labeled for in vivo 19F MRI cell tracking" Cytotherapy 2010, 12, 238-250.
  35. D.K.K. Kadayakkara, P. Beatty, J.M. Janjic, M. Turner, E. Ahrens, O. Finn "Inflammation driven overexpression of the hypoglycosylated abnormal MUC1 links inflammatory bowel disease (IBD) and pancreatitis" Pancreas 2010, 39, 510-515
  36. M. Srinivas, M.S. Turner, J.M. Janjic, P.A. Morel, D.H. Laidlaw, E.T. Ahrens "In vivo cytometry of antigen specific T-cells using 19F MRI" Magnetic Resonance in Medicine 2009, 62, 747-753
  37. J.M. Janjic, E.T. Ahrens "Fluorine-containing nanospheres for MRI" Advanced Reviews, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, Sept./Oct. 2009, 1, 492-501, invited by editors
  38. J.M. Janjic, M. Srinivas, D.K.K. Kadayakkara, E.T. Ahrens "Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection", Journal of American Chemical Society 2008, 130, 2832-2413. (highly cited paper, cited >200 times)
  39. Sarachine, M.J.; Janjic, J.M.; Wipf, P; Day, B.W. "Biphenyl C-cyclopropylalkylamides as new scaffolds for targeting estrogen receptor β" Bioorganic Medicinal Chemistry Letters 2009, 19, 2404-2408.
  40. Wipf, P.; Gong, H.; Janjic, J.M.; Li, S.; Day, B.W.; Xie, W. "New Opportunities for pregnane X receptor (PXR) targeting in drug development. Lessons from enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues" Mini Reviews Medicinal Chemistry 2007, 7, 617-625
  41. Wipf, P.; Coleman, C.M.; Janjic, J.M.; Iyer, P.S.; Fodor, M.D.; Shafer, Y. A. Stephenson, C.R. J.; Kendall, C.; Day, B.W. "Microwave-Assisted "Libraries from Libraries" Approach toward the Synthesis of Allyl- and C-Cyclopropylalkylamides," Journal of Combinatorial Chemistry 2005, 7, 322-330.
  42. Poloyac, S.M.; Rohan, L.C.; Janjic, J.M.; Gibbs, R.B.; Kroboth, P.D.; Smith, R.B.; "GEAR-UP (Graduate Education And Research at the University of Pittsburgh), A Program for Educating Students about Pharmaceutical Research," American Journal of Pharmaceutical Education 2005, 69, 91-97. (co-wrote the paper, co-designed the study, served on the organizational committee of the program 2001-2004)
  43. Janjic, J.M.; Mu, Y. ; Kendall, C.; Stephenson, C.R. J.; Balachandran, R.; Raccor, B. S. ; Lu, Y.; Zhu, G.; Xie, W.; Wipf, P.; Day, B. W. "New Antiestrogens from a Library Screen of Homoallylic Amides, Allylic Amides and C-Cyclopropylalkylamides," Bioorganic and Medicinal Chemistry 2005, 13, 157-164.
  44. Wipf, P.; Janjic, J.M.; Stephenson, C.R. "Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation-transmetalation-aldimine addition sequence," Organic and Biomolecular Chemistry 2004, 2, 443-445.
  45. Lu, G.; Janjic, B.M.; Janjic, J.; Whiteside, T.L.; Storkus, W.J.; Vujanovic, N.L. "Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1), -beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand," Journal of Immunology 2002, 168, 1831-1839.
Book Chapters
  1. W. Meng* and J.M. Janjic Book chapter "Principles of Nanomedicine " in book titled: Nanomedicine for Inflammatory Diseases edited by Lara Sheherazade Milane and Mansoor M. Amiji, invited by the editors, 2017 Nanomedicine for Inflammatory Diseases, 39-66
  2. J.M. Janjic* and S.K. Patel "Perfluorocarbon Theranostic Nanomedicines: Pharmaceutical Scientist's Perspective" book chapter in book titled: Fluorine Magnetic Resonance Imaging Edited by Ulrich Flögel & Eric Ahrens, invited by the editors, Pan Stanford Publishing Pte. Ltd. 2016 DOI: 10.1201/9781315364605-15
  3. J.M. Janjic*, S.K. Patel, C. Bagia "Utilization of Near-Infrared Fluorescent Imaging for Pharmaceutically Relevant Applications" Book chapter in 2016 In Vivo Fluorescence Imaging: Methods and Protocols, 97-108, edited by Mingfeng Bai, PhD, Springer New York 2016 DOI: 10.1007/978-1-4939-3721-9_10, invited by the editors
  4. J.M. Janjic and M. Bai "Design and Development of Theranostic Nanomedicines" Chapter in: Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, Edited by Mikhail Berezin, John Wiley & Sons, Inc; 2014, invited by the editors
Patents
  1. E.T. Ahrens and J.M. Janjic "Compositions and methods for producing emulsions for nuclear magnetic resonance techniques and other applications" 2016, US Patent 9,352,057, Assignee Celsense Inc.
  2. J.M. Janjic and E.T. Ahrens "Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques" 2012, US Patent 8,227,610, Assignee Carnegie Mellon University

Research Grants

Active Projects:

2019–21 PR180093P1 CDMRP, RTRP, Investigator-Initiated Research Award
Project Title: "A Novel Graft Implanted Macrophage-Enzyme Responsive Immunosuppressive Therapy (MERIT) to Prevent Chronic Rejection in Vascularized Composite Allotransplantation"
Role: Partnering PI with Initiating PI: Vijay Gorantla MD, PhD, WFIRM and Partnering PI: Praveen Vemula, PhD, Institute for Stem Cell Biology and Regenerative Medicine

2017–20 FA8650-17-2-6836 AIR FORCE MEDICAL SUPPORT AGENCY (AFMSA)
Project Title: A Targeted, Local, Non-Opioid Therapeutic Strategy for Mitigation, Modulation, and Management of Trauma Induced Neuropathic Pain
Role: Extramural PD/PI with Intramural PI: Col Erik Weitzel, MD 59th MDW, USAISR and Extramural Co-PI: Vijay Gorantla MD, PhD, WFIRM

Completed Projects:

2016–19 NIH R21EB023104-01 National Institute of Biomedical Engineering and Imaging
Project Title: "Multimodal (PET/MR/NIR) imaging supported drug delivery in inflammatory diseases"
Role: Principal Investigator (MPI with Carolyn Anderson, PhD, University of Pittsburgh)

2015–18 NIH R21 DA039621-01 National Institute on Drug Abuse
Project Title: "Theranostic Pain Nanomedicines: imaging inflammation, reducing pain and need for opioids."
Role: Principal Investigator

2017–18 Pennsylvania State Health Formula Research Grants Program (C.U.R.E. Award)
Project Title: "Investigation of the molecular basis of neuroinflammatory pain associated with cancer and cancer therapy; an exploration guided by nanotechnology"
Role: Co-Investigator (PI: J.A. Pollock)

2016–17 Leach Fund Award
Project Title: "An Innovative Anti-inflammatory Treatment for Duchenne Muscular Dystrophy"
Role: Co-Investigator (PI: Mathew Kostek, PhD)

2016-–17 Leach Fund Award
Project Title: "Investigation of the molecular basis of neuroinflammatory pain with nanotechnology; a potential therapy for chronic pain in animals and people"
Role: Co-Investigator (PI: J.A. Pollock)

*2014–17 The Provost's Office Interdisciplinary Research Consortia Seed Funds for the support of the Chronic Pain Research Consortium at Duquesne University
Founder and Co-Director (award Co-PI): Jelena M. Janjic, PhD (Pharmacy)
Co-Director (award Co-PI): John A. Pollock, PhD (Biological Sciences, BSNES)
Research and Education Coordinator (award Co-I): Benedict Kolber, PhD (Biological Sciences, BSNES)
Grant and Funding Coordinator (award Co-I): Kevin A. Tidgewell, PhD (Pharmacy)

2014 N00014-14-1-0723 Office of Naval Research
Project Title: Acquisition of a shear rheometer for research on tissue scaffold ECM hydrogels and other biomaterials
PI: Sachin Velankar, PhD (Swanson School of Engineering, University of Pittsburgh)
Role: Co-Investigator, (theranostic hydrogels design and development, rheological assessment of complex hydrogels)

2011–14 1R15AI081218-01A2 NIH, NIAID (National Institute of Allergy and Infectious Diseases)
Project Title: "Non-viral Genetic Modification of Antigen-presenting Cells in Allografts"
PI: Wilson Meng, PhD (Pharmacy, Duquesne University)
Role: Co-Investigator, Imaging support (MRI/optical reagent design and development, in vitro assessment)

2011–13 Pittsburgh Tissue Engineering Initiative Interface Seed Grant Fund
Project Title: "Acute to Chronic Pain Transition in Postsurgical Recovery: Combined input from immune system and peripheral nervous system"
Role: Partnering PI (with John Pollock, PhD)

2011–13 Pennsylvania State Health Formula Research Grants Program (C.U.R.E. Award)
Project Title: "From Insoluble Perfluorocarbon Oils to Multifunctional Nanoparticles for Breast Cancer Imaging and Treatment"
Role: Principal Investigator

*2010–12 Faculty Development Funds, Duquesne University
Project Title: "Perfluorocarbon nanoemulsions for simultaneous delivery of COX2 inhibitor and antiproliferative agents to breast tumors"
Role: Principal Investigator

2009–10 STTR, 1R41EB009618 - 01A1 NIH, NIBIB (National Institute of Biomedical Imaging and Bioengineering)
Project Title: "Dual Mode Nanoemulsions for 19F MRI and Fluorescence Detection"
Role: Principal Investigator (Consortium with Celsense Inc, Pittsburgh PA)

2008–13 5P41EB001977-22 NMR Center Grant "A MULTIDISCIPLINARY NMR CENTER FOR BIOMEDICAL RESEARCH" Program Director Prof. Chen Ho, Carnegie Mellon University;
Project TRD3 "Cell Labeling Chemistry to Make In-vivo MRI a Practical Method"
Project Leader: Alan S. Waggoner, PhD, Carnegie Mellon University
Role: Investigator (2008-2009), MRI/Optical bimodal nanoreagent development, formulation design, quality control and assessment

2006–07 1R21NS056998-01 NIH, NINDS (National Institute of Neurological Disorders and Stroke) "Assay Development for Identification of ER-NFkB Pathway Selective Agents"
PI: K. Nettles, PhD, Scripps Florida
Role: Research Associate (2006), HTS assay development for small molecule drug screening

2004– 05 BC030739 Department of Defense Breast Cancer Research Program
Project Title: "Design, Synthesis and Biological Evaluation of Focused Combinatorial Libraries of Antiestrogens" Pre-doctoral Fellowship
Role: Principal Investigator, ER ligand design, synthesis, SAR and pharmacological testing in vitro

Education Grants Awarded

2014 Procurement of specialized equipment (Microfluidizer M-110EH-30) and professional training for the graduate course GPSC 508: Pharmaceutical Manufacturing Laboratory (Spring 2014). Microfluidics Corp. and Divitech donated 6 months equipment rental and training.

2014–19 NIH R25 SEPA "Partnerships in Neuroscience Education.
This award from the Office of the Director is for public science education on issues of neuroscience including pain, learning, and memory using multimedia and digital devices.
PI: John A. Pollock, PhD (Biological Sciences, Duquesne University)
Role: Scientific content editor and advisor

Scholarly Presentations

(Presenter is underlined; *Corresponding author)

Invited Lectures (National & International)
  1. Janjic J.M. "Peripheral Nerve Injury: Opportunities and Challenges for Diagnosis and Treatment using Nanotechnology" NeuroTrauma 2019, LW9: Neuroscience Tools for Neurotrauma; July 3, 2019, Pittsburgh, PA
  2. Janjic J.M. "Engineering Personalized Nanomedicine for Inflammation and Pain" MD Anderson Anesthesiology & Neuroscience Seminar Series, January 10th, 2019, Huston, Texas
  3. Janjic J.M. "Novel Nanomedicine Strategies for Non-Invasive Monitoring of Neuroinflammation and Non-Opioid Pain Management in Service Members and Veterans" Session: Restorative Endeavor for Service members Through Optimization of Reconstruction (RESTOR) at AMSUS Annual Meeting, November 30, 2018, National Harbor, Washington DC
  4. Janjic J.M.* Keynote lecture: "Nanomedicine Advances in Targeted Imaging and Treatment of Inflammation: Potential and Prospects in VCA" at American Society for Reconstructive Transplantation (ASRT) 6th Biennial Meeting, November 15 - 17, 2018 in Chicago, IL.
  5. Janjic J.M.* "Nanomedicine Strategies for VCA - Prospects and Potential" State-of-the-Art Session: Novel Technologies and Tools in VCA (Vascular Composite Allotransplantation) at 27th International Congress of the Transplantation Society in Madrid, Spain, July 2, 2018 and Session co-chair for "Oral Abstracts in VCA" on July 5, 2018 https://tts.guide/webapp/timeslot/257
  6. Janjic J.M.* "Personalized Nanomedicine Strategies for Regenerative, Resuscitative and Restorative Combat Casualty Applications" Tri-Symposium Science Seminar at USAISR, RESTOR Program, 59th Medical Wing, Airforce, San Antonio Texas, Feb 21, 2018, Hosted by Col. Erik Weitzel
  7. Janjic J.M.* (Chair, Symposia: Exploiting Cellular and Molecular Mechanisms of Neuroinflammation for New Treatments of Chronic Pain at APS Scientific Summit March 4-6, 2018 Anaheim, CA | Disneyland® Hotel. Symposia presenters: Jelena M. Janjic, Theodore Price, PhD, University of Texas in Dallas and Edgar Alfonso Romero-Sandoval, MD PhD, Wake Forest University
  8. Janjic, J.M. Invited speaker, talk title: "Theranostic Fluorous Nanocolloids: A Story of Powerful Droplets" International Symposium on Fluorous Technologies - 2017 (ISoFT17), Boston, MA, USA, Aug 9-11, 2017
  9. Janjic, J.M. Invited speaker and panelist at: The Sixth Annual Meeting of the American College of Wound Healing and Tissue Repair December 1-3, 2016 Chicago, IL in the Session 4: Stem Cell and Regenerative Medicine: Talk: "Nanotheranostics: Targeted NIRF Labeled Drug Delivery to Visualize Macrophage Activity in Inflammation and Regeneration" and Roundtable Discussion: "How Can We Tackle Large Scale Tissue Regeneration and Reconstruction Through Precision Medicine?"
  10. Janjic, J.M. Engineering perfluoropolyether colloids for multimodal (19F MR/PET/NIR) imaging supported drug delivery (POLY 222): Invited talk at Polymeric Materials as Imaging Agents & Theranostics Symposia at 252nd ACS National Meeting in Philadelphia, PA, August 21-25, 2016.
  11. Janjic J.M.* (Chair, Symposia: Expanding the Toolbox: Theranostic Nanomedicine and Systems Biology Applied to Pain Research and Treatment at American Pain Society Scientific National Meeting in Palm Springs, CA, June 13-16th, 2015. Symposia presenters: Prof. Gerard Gebhart, University of Pittsburgh; Prof. Yoram Vodovotz, University of Pittsburgh and Prof. John A. Pollock, Duquesne University and Jelena M. Janjic, Duquesne University.
  12. Janjic J.M.* talk title: Triphasic (Fluorous/Organic/Aqeous) Nanoemulsions as a Theranostic Nanomedicine Platform for Inflammatory Diseases, 21st International Symposium on Fluorine Chemistry which is organized jointly with the International Symposium on Fluorous Technologies 2015 in Como (Italy), 23-28, August 2015
  13. Janjic J.M.* (session Chair with J. A. Pollock as Co-Chair) for the working session titled: "Chronic Pain and Inflammation" at McGowan Institute Research Retreat at Nemacolin Woodlands Resort, Farmington, PA, USA March 9-11 2014, Janjic J.M. talk titled: "Theranostic Pain Nanomedicine: Entry to the New Era of Inflammatory Pain Research?"
  14. Janjic, J.M.* "Perfluorocarbons as a new platform for personalized medicine" 21st Winter Fluorine Conference St. Jan 13-18 2013 Pete's Beach, FL, USA, invited by Prof. Michael Gerken, Conference Chair
  15. Janjic, J.M.* "Suppressing inflammation from inside out with novel NIR visible perfluorocarbon nanotheranostics" SPIE Photonics West, Feb 2-7 2013 invited by the session chair Walter Akers, PhD, University of Washington School of Medicine, San Francisco, CA
  16. Janjic, J.M.* "Perfluorocarbons: Promising Materials for Pharmaceutical Process-Friendly Theranostics" UMass Boston Chemistry Colloquium invited and hosted by Prof. Wei Zhang Oct 24th 2012, Boston, MA
  17. Janjic, J.M.* "From Inert Perfluorocarbons to Theranostic Agents: A road less travelled" Invited lecture at The Faculty of Pharmacy, University of Ljubljana, invited and hosted by Prof. Borut Strukelj, March 3rd, 2011, Ljubljana, Slovenia (EU)
Regional & Local
  1. Janjic J.M. Session chair: Emerging Military Threats, Combat Casualty Gaps and Opportunities for Innovation at McGowan Institute for Regenerative Medicine 2019 Annual Retreat; Talk title: Inflammation Targeted Nanomedicine for Military Applications: Design, Manufacturing, and Quality Control"
  2. Janjic J.M. "Pain Nanomedicine: The Lived Experience" talk at the GRADUATE PROGRAM AWARDS DINNER, University of Pittsburgh School of Pharmacy, Graduate Program in Pharmaceutical Sciences, Wednesday, June 21, 2017
  3. Janjic J.M. "Nature, Nurture and Nanomedicine.The Future of Immunotherapy is Nanocolloids"" presented at The Center for Cellular and Molecular Engineering (CCME), McGowan Institute for Regenerative Medicine, University of Pittsburgh, May 2nd, 2017
  4. Janjic J.M. "Nanotheranostics: Modulation of Macrophage Activity in Inflammation, Regeneration and Pain" Seminar at Integrative Graduate Education and Research Traineeship (IGERT), West Virginia University, March 28th , 2017
  5. Janjic J.M. "Theranostic Pain Nanomedicine" McGowan Injury, Repair and Regenerative Medicine Seminar Series, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, February 7th, 2017
  6. Janjic J.M.* "Theranostic nanoemulsions in pain and inflammation" October 29th, 2014 Department of Radiology Research Seminar, University of Pittsburgh, host Prof. Carolyn Anderson, Department of Radiology
  7. Janjic J.M.* "COX-2 Inhibiting Theranostic Nanoemulsions and their Application to Inflammation Investigations from Cancer to Chronic Pain" University of Pittsburgh Cancer Institute Basic & Translational Research Seminar Series, invited and hosted by Dr. Michael Gach, University of Pittsburgh Cancer Institute January 21, 2014, Pittsburgh, PA
  8. Janjic J.M.* "All Dosage Forms Theranostic; All Medicine Personalized Medicine." Fall 2013 Seminar Series Department of Biological Sciences, BSNES, Duquesne University, invited and hosted by Dr. John Pollock Sept 6th, 2013, Pittsburgh, PA
  9. Janjic J.M.* "Perfluorocarbon Theranostics for Imaging and Treatment of Inflammation in Preclinical Models" Center for Inflammation and Regeneration Modeling (CIRM), McGowan Institute for Regenerative Medicine, University of Pittsburgh, invited and hosted by Prof. Yoram Vodovotz, May 24th 2012, Pittsburgh, PA
  10. Janjic, J.M.* "Perfluorocarbon Theranostics: From a Pharmaceutical Scientist's Perspective" invited seminar at University of Pittsburgh School of Medicine, Department of Radiology, invited and hosted by Prof. Mingfeng Bai, PhD Dec 9th 2011, Pittsburgh, PA

Oral Presentations

(Presenter is underlined; *Corresponding author)

National & International
  1. J. M. Janjic, L. Liu, M. Herneisey, E. Lambert, F. Zor, H. Karagoz, V. Gorantla: "It Only Takes One: Chronic Inflammation and Pain Control with a Single Dose of a Targeted Nanomedicine" 2019 TechConnect World Innovation Conference & Expo, June 16-19, Boston, MA; Session Name: Nanoparticles in Diagnostics & Imaging/ Session Chair.
  2. Janjic J.M. "Perfluoropolyether Nanomedicines as Controllable Immunomodulators in Inflammatory Diseases"" Advances in Functional Materials, UCLA, LA, CA, August 13-17, 2017 - Session Chair
  3. Janjic, J.M. * "The Road to True Theranostic Nanoreagents is Paved with Perfluorocarbons" Symposium in Honor of Donald J. Burton: Fluorine Chemistry the Iowa Way, American Chemical Society 242nd National Meeting, Aug. 29 - Sept. 1 2011, Denver, CO
  4. Janjic, J.M.; Kadayakkara, D.K.K.; Hitchens, K.T.; Ahrens, E.T.* "Multispectral 19F MRI Reagents - Design, Synthesis and Biological Evaluation" Fluorine Chemistry Symposia, American Chemical Society 236th National Meeting Aug. 17-21 2008, Philadelphia, PA
  5. Janjic, J.M.; Srinivas, M.; Kadayakkara, D.K.K.; Ahrens, E.T.* "Synthesis of novel dual-mode 'self-delivering' nanoparticles for in vivo fluorine-19 MRI and fluorescence cell tracking" Joint Molecular Imaging Conference, Sep. 8-11 2007, Providence, RI

Select Abstracts from Poster and Oral Presentations

National, International & Regional
  1. J Janjic*, L Liu, T Komatsu, M Herneisey, S Loftus, E Lambert, F Zor, V. Gorantla (136) "Dual Targeted Theranostic Nanomedicines for Local and Systemic Non-Opioid Analgesia in Trauma" American Pain Society National Meeting, April 1, 2019 Milwaukee, WI: published in The Journal of Pain 2019, 20 (4), S10
  2. M. Herneisey, G. Mejia, G. Pradhan, I. Sankaranarayanan, M. Kume, G. Dussor, T. Price, J. Janjic*, Abstract PSN507 Resveratrol Loaded Nanoemulsions and Microemulsions Designed as Safe, Natural Alternatives to Opioids for the Treatment of Surgically Induced Chronic Pain, IASP 17th WORLD CONGRESS ON PAIN, 2018, Boston, MA, USA
  3. E. Lambert, V.S. Gorantla, J. M. Janjic*, Abstract PTH252 Mixture Models to Predict Colloidal Properties of Triphasic Nanoemulsions Designed for Pain Treatment and Neuroregeneration, IASP 17th WORLD CONGRESS ON PAIN, 2018, Boston, MA, USA
  4. L. Liu, M. Herneisey, S. Loftus, E. Lambert, J. Janjic*, Abstract PST170 Analgesic and Anti-inflammatory COX-2 Targeted Locally Injectable Nanoemulgel in a Murine Inflammatory Pain Model, IASP 17th WORLD CONGRESS ON PAIN, 2018, Boston, MA, USA
  5. Lu Liu, Takaaki Komatsu, Fatih Zor, Vijay S. Gorantla, Jelena M. Janjic* "Sustained analgesic and anti-inflammatory efficacy of single dose COX-2 inhibiting nanomedicine in a murine inflammatory pain model" American Pain Society scientific Summit 2018 in Anaheim, CA, United States, March, 2018
  6. Matthew J. Wordsworh, Lu Liu, Shannon Loftus, Michele L. Herneisey, Vijay S. Grantla, Erik K. Weitzel, Jelena M. Janjic* "A novel targeted local analgesia platform to mitigate neuroinflammation and promote neuroregeneration" American Pain Society scientific Summit 2018 in Anaheim, CA, United States, March, 2018
  7. Andrea Stevens, Muzmil Saleem, Yongrim Lee, Lu Liu, Jelena M. Janjic, John A. Pollock* "Differential gene expression of neuroinflammatory mediators following administration of macrophage targeted nanoparticles in peripheral neuropathy" American Pain Society scientific Summit 2018 in Anaheim, CA, United States, March, 2018
  8. Muzmil Saleem, Jelena M. Janjic, Lu Liu, John A. Pollock* "Peripheral and DRG expression of MCP-1 following administration of anti-inflammatory drug-loaded nanoemulsion in a rat CCI model" American Pain Society scientific Summit 2018 in Anaheim, CA, United States, March, 2018
  9. Stevens A, Saleem M, Liu S, Janjic J, Pollock J. "Peripheral gene expression changes in chronic constriction injury (CCI) rat model at the sciatic nerve following administration neuroinflammation targeted nanoparticles" American Pain Society Annual Scientific Meeting. May 17 - 20, 2017. Pittsburgh, PA. Abstract in The Journal of Pain 18 (4), S16-S17
  10. Michele Herneisey (PhD Candidate) "Design and formulation of nanoemulsion drug delivery systems with multimodal (NIR, MRI and PET) imaging properties (POLY 218) at Polymeric Materials as Imaging Agents & Theranostics Symposia at 252nd ACS National Meeting in Philadelphia, PA, August 21-25, 2016
  11. Abadjian M-C, Herneisey M, Janjic JM, Anderson CJ. Synthesis of chelator-fatty acid derived surfactants for nanoemulsion formulation of multimodality positron emission tomography (PET) and MR imaging drug delivery systems. Oral presentation; 252nd ACS National Meeting, Philadelphia, PA, August, 2016.
  12. Lambert, E., Ford. T, Kothapalli, SV, Chen, H and Janjic, JM "Formulation development of PFPE nanoemulsions for HIFU-triggered drug delivery" at 252nd ACS National Meeting in Philadelphia, PA, August 21-25, 2016
  13. Takaaki Komatsu (Fellow), Lu Liu (PhD Candidate), J.M. Janjic* "Investigation of macrophage targeted analgesic nanoparticles in an LPS mouse model" Poster Presented at 16th World Congress on Pain by IASP in Yokohama, Japan, September 26-30, 2016
  14. Michele Herneisey, Simai Liu, and Jelena M. Janjic* Title: "Active targeting of inflammatory macrophages with folate decorated nanoemulsions containing bimodal fluoropolymers." Presented at: 15th Annual McGowan Institute for Regenerative Medicine Scientific Retreat, Farmington, PA. (March 2016)
  15. Michele Herneisey, Marie Caline Abadjian, Wissam Beaino, Sravan Kumar Patel, Carolyn J. Anderson, Kevin T. Hitchens, Jelena M. Janjic* Title: "Modification of Nanoemulsions with 19F MRI Imaging Capabilities to Incorporate PET Imaging Modalities." Presented at: Pittsburgh MR Imaging Community Retreat, Pittsburgh, PA, November 2015.
  16. Beaino W, Patel S, Herneissy M, Abadjian MC, Janjic J, Anderson CJ*. Image-Guided Drug Delivery to Macrophages for Targeting Inflammation. World Molecular Imaging Conference, September, 2015, Honolulu, Hawaii
  17. Saleem, M., Vasudeva, K., Patel, S.K., Hitchens, K.T., Stevens, A., Janjic, J.M., Pollock, J. A.* Mechanical hypersensitivity reversal with drug-loaded nanoemulsion in a CCI model. Program No. 62.23. Neuroscience 2015 Abstracts. Chicago, IL: Society for Neuroscience, 2015. Online.
  18. Saleem, M., Vasudeva, K., Patel, S.K., Hitchens, K.T., Stevens, A., Janjic, J.M.*, Pollock, J. A. Theranostic nanoemulsion-loaded drug reverses hypersensitivity in a rat CCI model. Barriers to the Translation of Pain Research meeting, University of Pittsburgh, Pittsburgh PA. June 11 and 12 2015. - Awarded Gerald F Gebhart Distinguished Research Prize for poster presentation.
  19. Saleem, M., Janjic, J.M.,Vasudeva, K., Andersen, B., Zeyzus-Johns, T.K., Hitchens, T.K., Patel, S.K., Pollock, J.A. Nanotheranostics as a tool for search, rescue and discovery: Understanding chronic pain processing in the peripheral nervous system. Program No. 243.02. Neuroscience 2014 Abstracts. Washington, DC: Society for Neuroscience, 2014. Online.
  20. Michele Herneisey, Marie Caline Abadjian, Carolyn Anderson, and Jelena M. Janjic. Title: "Design and formulation of nanoemulsion drug delivery systems with multimodal (NIR, MRI, and PET) imaging properties." AAPS Student Symposium, Duquesne University, Pittsburgh, PA. October 2016
  21. Michele Herneisey, Marie Caline Abadjian, Simai Liu, Carolyn J. Anderson, and Jelena M. Janjic* Title: Perfluorocarbon Nanoemulsions Revisited: Strategies for the improvement of anti-inflammatory theranostic nanoemulsion platforms. Presented at: 28th Annual UPCI Scientific Retreat, University of Pittsburgh at Greensburg, PA. June 2016
  22. Michele Herneisey, Marie Caline Abadjian, Wissam Beaino, Sravan Kumar Patel, Caroline J. Anderson, Jelena M. Janjic* Title: "Formulation of Nanoemulsions with Positron Emission Tomography Imaging Modalities." Presented at: 11th Annual Metals in Biology Mini-Symposium, Duquesne University, Pittsburgh, PA. September 2015
  23. Michele Herneisey, Janja Mirtic, Jonathan Williams, Lu Liu, Sneha Potdar, Christina Bagia, Jane C. Cavanaugh, and Jelena M. Janjic* Title: "Theranostic Resveratrol Nanoemulsions Target Inflammation via the Macrophage." Presented at: AAPS Student Symposium, West Virginia University, Morgantown, WV. June 2015
  24. Michele Herneisey, Sneha Potdar, Janja Mirtic, Christina Bagia, Lu Liu, Sravan Kumar Patel, Jonathan Williams, Jane Cavanaugh, Jelena M. Janjic* Title: "Resveratrol-loaded theranostic nanoemulsions target inflammation via the macrophage." Presented at: 14th Annual McGowan Institute for Regenerative Medicine Scientific Retreat, Farmington, PA. March 2015
  25. Patel, S.K., Beaino, W., Bagia, C., Anderson, C., Janjic J.M.* "Theranostic Nanoemulsions for Macrophage Targeted Drug Delivery and Imaging in Inflammatory Diseases" 2014 AAPS Annual Meeting and Exposition, November 2-6, 2014, San Diego, CA (Abstract # 897)
  26. Bagia C., George S.,Domenech T., Yang X., Hitchens K., Velankar S., Janjic J.M.* "Polyamine Cross-Linked Perfluorocarbon Gels as Bimodal (Optical/MRI) Imaging Supported Delivery Platform" 2014 AAPS Annual Meeting and Exposition, November 2-6, 2014, San Diego, CA (Abstract # 2703)
  27. Jeric, I., Bagia C., George S., Yang X., Liu L., Domenech T., Velankar S. and Janjic J.M.* "Theranostic Emulgels for Imaging Supported Drug Delivery" 2014 AAPS Annual Meeting and Exposition, November 2-6, 2014, San Diego, CA (Abstract # 1305)
  28. Zhang S., Shao P., Jia N., Bagia C., Janjic J.M., Ding Y., Bai M.* "CB2 Receptor: a New Target for Phototherapy Treatment" World Molecular Imaging Congress Sept 17-20 2014, Seoul, Korea
  29. Janjic J.M.*, Bagia C., Patel S.K. "Theranostics nanoemulsions as new tools for studying inflammation in chronic pain preclinical models" American Pain Society 33rd Annual Scientific Meeting April 30-May 3 2014, Tampa, FL Abstract published in: The Journal of Pain 2014, Vol. 15 (4), S76-S76
  30. Vasudeva K., Patel S., Saleem M., Balducci A., Hitchens T., Janjic J.M., Pollock J.A.* "In-vivo imaging of neuro-inflammation in rat model of chronic neuropathic pain using a dual mode nanoemulsion" American Pain Society 33rd Annual Scientific Meeting April 30-May 3 2014, Tampa, FL Abstract published in: The Journal of Pain 2014, 15 (4), S49-S49
  31. Bagia C., Domenech T., Jeric I., George S., Yang X., Janjic B., Hitchens T.K., Berlec A., Strukelj B., Velankar S., Janjic J.M.* "Theranostic Perfluorocarbon Hydrogels: Novel Integrated Approach to Therapeutic Payload Delivery" McGowan Institute Research Retreat March 9-11 2014, Nemacolin Woodlands Resort, Farmington, PA
  32. Patel, SK and Janjic, J.M.* "Perfluorocarbon Nanoemulsions as a Versatile Platform for Anti-inflammatory Drug Delivery and Inflammation Imaging" World Molecular Imaging Congress September 19-23, 2013, Savannah, GA (Travel award winner)
  33. Janjic, J.M.*, Moutnain, G., Pate. S.K., DiVito, E., Cascio M., Pollock, J.A. "Theranostic Nanomedicine for Chronic Pain: Opportunities unexplored" Midwest Regional Pain Interest Group (MRPIG) Annual Meeting, Aug 23-24 2013, Cincinnati, OH
  34. Janjic, J.M.*, Patel, S.K., Wen, Y., Balducci, A., Meng, W. "Theranostic Perfluorocarbon Nanoemulsions" Gordon Research Conference: Colloidal, Macromolecular & Polyelectrolyte Solutions, February 5-10, 2012, Ventura, CA
  35. Janjic, J.M.*, Patel, S.K., Vasudeva, K., Andersen, K., Zhang, Y., Balducci, A., Hitchens, T.K., Pollock, J.A. "First Perfluorocarbon Nanotheranostic for Neuroinflammation Imaging and Treatment" CHI World Pharma Congress: Targeting Pain with Novel Therapeutics, June 6-7 2012, Philadelphia, PA
  36. Patel, S.K., Janjic, J.M.* "Preparation and Optimization of Perfluorocarbon and Hydrocarbon Nanoemulsions using Non-ionic Surfactants for Drug Delivery and Imaging" American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, October 23-27, 2011, Washington, D.C.
  37. Patel, S.K., O'Hanlon, C.E., Janjic, J.M.* "Perfluorinated Lipids for Drug Delivery" Winter Fluorine Conference Jan. 9-14 2011 St. Pete's Beach, FL, 1st PRIZE WINNER for BEST POSTER
  38. O'Hanlon, C.E.; Amede, K.; Kadayakkara, D.K.K.; Ahrens, E.T.; Janjic, J.M.* "Self-assembling perfluorocarbon nanoemulsions for drug delivery and imaging" American Association of Pharmaceutical Scientists (AAPS) National Biotechnology Conference May May 16-18, 2011 San Francisco, CA
  39. Janjic, J.M.*, O'Hanlon, C.E., Tunney, R. "PFC Based, MR Detectable Nanoemulsions for Celocoxib Delivery to Breast Tumors" CHI World Pharmaceutical Congress, Philadelphia, PA, June 16-17, 2010
  40. Patel, S.K., Jaswal,S., Kadayakkara, D.K.K., O'Hanlon, C.E., Ahrens, E.T., Janjic, J.M.* "Fluorinated Nanoemulsions and Liposomes for Drug Delivery: Design, Synthesis and Formulation" Pharmaceutics Graduate Student Research Meeting (PGSRM) 17-19 June, 2010 Columbus, Ohio
  41. Janjic, J.M.; Patrick, M.J.; Schmidt, B.F.; Mailliard, R.; Waggoner, A.S.; Ahrens, E.T.* "Multimodal fluorine containing nanoemulsions with biosensing properties" World Molecular Imaging Congress, Sept. 23-26, 2009, Montréal, Canada
  42. Janjic, J.M.; Kadayakkara, D.K.K.; Pusateri, L.K.; Ahrens, E.T. "Novel perfluorocarbon nanoemulsions for 19F MRI cell trackgin of two cell populations in vivo" International Society for Magnetic Resonance in Medicine International Meeting (ISMRM) 17th Scientific Meeting & Exhibition Honolulu, Hawai'i, USA 18-24 April 2009, e-poster
  43. Saranchine, M.; Janjic, J.M.; Coleman, C.; Wipf, P.; Day, B.W. "Biphenyl C-Cyclopropylkylamides as New Scaffolds for Targeting Estrogen Receptor Beta" 31st National Medicinal Chemistry Symposium, American Chemical Society, June 15-18th, Pittsburgh, PA, 2008, poster
  44. Srinivas, M.; Turner, M. S.; Morel, P. A.; Janjic, J. M.; Laidlaw, D. H.; Ahrens, E. T. "Longitudinal tracking and quantification of T cells using in vivo 19F MRI" International Society for Magnetic Resonance in Medicine International Meeting (ISMRM) 16th Scientific Meeting & Exhibition, Toronto, Canada, May 3-9 2008, oral presentation - 4th best abstract
  45. Kadayakkara, D. K.; Pusateri, L. K.; Xu, H.; Janjic, J. M.; Ahrens, E.T. "In vivo intracellular pO2 measurements of perfluorocarbon labeled 9L glioma cells" International Society for Magnetic Resonance in Medicine International Meeting (ISMRM) 16th Scientific Meeting & Exhibition, Toronto, Canada, May 3-9 2008, oral presentation
  46. Hitchens, T. K.; Ye, Q.; Zhang, H.; Foley, L. M.; Janjic, J. M.; Ahrens, E. T.; Ho, C. " 19F MRI Detection of Acute Cardiac Allograft Rejection with In Situ Perfluorocarbon Labeling of Immune Cells" International Society for Magnetic Resonance in Medicine International Meeting (ISMRM) 16th Scientific Meeting & Exhibition, Toronto, Canada, May 3-9 2008, poster
  47. Janjic, J.M.; Saranchine, M.; Coleman, C.; Wipf, P.; Day, B.W. "New Ligands for Estrogen Receptors, American Chemical Society National Meeting, Washington DC, 2005, poster
  48. Janjic, J.M.; Wipf, P.; Day, B.; "New Antiestrogens from Libraries of Homoallylic amides, Allylic amides and C-Cyclopropylalkylamides", Era of Hope, Philadelphia, PA, 2005, poster
  49. Janjic, J.M.; Coleman, C.; Wipf, P.; Day, B.W.; "Targeting Agents for ERα and ERβ: Fluorescence Polarization Based Screening," CHI High-Content Analysis, San Francisco CA, 2005, poster
  50. Janjic, J.M.; Coleman, C.; Kendall, C.; Stephenson, C.R. J.; Mu, Y.; Xie, W.; Day, B.W.; Wipf, P.; "New Antiestrogens from Library Screens of Homoallylic Amides, Allylic Amides and C-Cyclopropylalkylamides" National Medicinal Chemistry Symposium, Madison WI, 2004, poster
Teaching

Teaching areas include: Pharmaceutics, Pharmaceutical Manufacturing, Molecular Imaging, Drug Delivery, Pharmacology, Medicinal Chemistry, Physiology and Pathophysiology.

Graduate Courses Taught (2009–Present)

Duquesne University Graduate School of Pharmaceutical Sciences, Pittsburgh, PA
GPSC 501 Pharmaceutical Unit Operations and Formulation (1 credit/team taught, 3 cr. course). Formulation and manufacturing of liquids and semisolids
GPSC 508 Pharmaceutical Manufacturing Laboratory (2 credits/team taught, 3 cr. course). Formulation and manufacturing of liquids and semisolids, nanoemulsions project leader, experimental design
GPSC 513 Principles of Drug Action, Design, and Delivery (course-master, 1.5 credit/team taught/course master, 3 cr. course). Medicinal chemistry section and drug discovery
GPSC 617 Pharmaceutical Biotechnology (0.5 credit/team taught, 2 cr. course). Design of imaging reagents
GPSC 619 Drug Delivery Systems (course master, 2 cr. course). Drug delivery vehicle design and targeting, focus on cancer therapeutics, theranostics, imaging agents, Biodesign and product development.

PharmD Courses Taught (2007–Present)

Duquesne University School of Pharmacy, Pittsburgh, PA
PHBM 355 Human Physiology and Pathophysiology I (course-master, 1.5 credits/team taught, 4 cr. course). Chemistry of life, basic biochemical topics in genetics and pharmacogenetics, genetic diseases
PHBM 442 Biomedical Sciences and Therapeutics: Gastroenterology (0.7 credits/team taught, 3 cr. course). Gastrointestinal disorder therapeutics (medicinal chemistry) and pharmacology
PHBM 442-71 Biomedical Sciences and Therapeutics: Gastroenterology (0.7 credits/team taught, 3 cr. course). Gastrointestinal disorder therapeutics (medicinal chemistry) and pharmacology
BSMT 426-71 Biomedical Sciences & Therapeutics: Infectious Disease (2 credits/team taught, 3 cr. course). Medicinal chemistry of infectious disease drugs
BMST 425-71 Biomedical Sciences & Therapeutics: Endocrine/Nutrition (1 credit/team taught, 3 cr. course). Medicinal chemistry of steroid and hormonal drugs
PHBM 435 Biomedical Sciences & Therapeutics: Pain, Musculoskeletal, and Connective Tissue Disorders (0.2 credit/team taught, 2 cr. course).
PHCE 360 Pharmaceutical Principles and Drug Delivery Systems I (1 credit/team taught, 3 cr. course).
PHPR 427-61/
UPNS 491-61
Etiology, Assessment and Treatment of Pain for the Health Care Professional (0.5 credit/team taught, 2 cr. course). Medicinal chemistry of analgesics, inflammation and pain, mindfulness/meditation in pain management. Cross- disciplinary course offered through School of Nursing and School of Pharmacy
University of Pittsburgh School of Pharmacy, Pittsburgh, PA (2001-2004)
PHARM 5318 Endocrinology, (guest lecturer, 0.5 credit, 3 cr. course). Lectures and practicum on steroid hormones, estrogens, SERMs and breast cancer

Presentations Pertaining to Teaching & Service

National Meetings
  • Janjic, J.M. 60 minutes Practice Session "Taste of Mindfulness and Embodied Learning in Pharmaceutical Sciences" at the 8th annual Association for Contemplative Mind in Higher Education Conference, "Transforming Higher Education: Fostering Contemplative Inquiry, Community, and Social Action," October 7-9, 2016 at the University of Massachusetts Amherst, Amherst MA.
  • Janjic, J.M. "Mindfulness in the classroom" Round table discussion/presentation, Wakonse Faculty Conference, May 24-29, 2013, Camp Miniwanca on Lake Michigan. (20 session participants)
  • Janjic, J.M. 60 minutes Practice Session "Welcoming the emotional life of teaching through mindfulness practice," at the fifth annual Association for Contemplative Mind in Higher Education Conference, "Integrity of Practice: A Contemplative Vision for Higher Education," Amherst College, Amherst, MA, November 8-10, 2013
Local/Regional Events
  • Janjic, J.M. "The unlikely scientist. Embracing the unknown and trusting the inner voice " at "Women in Science Evening" at Chemistry Club at Seton Hill University, Greensburg, PA, April 2015
  • Janjic, J.M. "Trusting that you'll get there! From pharmacy school freshman to pharmacy school professor." Career seminar at 2nd Annual MGDB-CBMP Scientific Retreat, University of Pittsburgh, May 31st 2013 at the Hilton Garden Inn Pittsburgh University Place
  • Janjic, J.M. "Got some perfluorocarbons? A medicinal chemist's story" April 23rd 2012: University of Pittsburgh School of Pharmacy AAPS student chapter "How we got here: Career development in basic and clinical pharmaceutical sciences", joint alumni and career event with Duquesne University and West Virginia University
University Events
  • Symposium Chair and Lead Organizer "State of the Art Symposium: ADVANCED BIOMEDICAL STRATEGIES FOR DEFENSE APPLICATIONS: Need, Opportunities and Challenges for Collaborative Research" March 13, 2019, Power Center, Duquesne University 
  • Soloist (lead organizer) at "Healing power of music" Chronic Pain Research Consortium/City Music Center Piano Recital, July 26th, 2017
  • Designer and leader of a Workshop: "Integrating the Inner/Outer World in Teaching" for faculty at the Department of Instruction and Leadership in Education (DILE) annual retreat on May 4, 2016 (Designer and leader)
  • Panelist at the founding meeting of Women in Science, Duquesne University, July 2016
  • Organizer and facilitator of SPEAK UP event for elementary and middle school girls with Women in Science, Duquesne University, April 1, 2017 - event focused on teaching young girls negotiation skills
  • Panelist (with Mathew Kostek) at Workshop: "Spiritan Pedagogy Across Classroom Contexts." Led by Dr. Darlene Weaver, March 2015
  • Presentation/practice (Janjic): "Contemplative focus on your story" at the Inspired Teaching Retreat May 15-16, 2014. Theme: What Our Stories Teach Us. Leaders: Jelena M. Janjic (Pharmacy), Matt Kostek (Physical Therapy), Leslie Lewis (Gumberg), Steve Hansen & Laurel Willingham-McLain (Center for Teaching Excellence).
  • Presentation/practice (Janjic): "Mindful Teachers" and "Mindful Teaching" at the Inspired Teaching Retreat May 9-10, 2013. Theme: Teaching as Whole Persons. Leaders: Jelena M. Janjic (Pharmacy), Leslie Lewis (Gumberg), Steve Hansen & Laurel Willingham-McLain (Center for Teaching Excellence).
  • Presentation/Practice (Janjic): "Mindfulness" at the Inspired Teaching Retreat May 11-12, 2012. Theme: Integrating Life and Learning. Leaders: Susan Goldberg (Psychology) Jelena M. Janjic (Pharmacy), Leslie Lewis (Gumberg), Steve Hansen & Laurel Willingham-McLain (Center for Teaching Excellence).
  • Presenters: Steven Hansen (CTE), Ann Marie Hansen (Occupational Therapy) and Jelena M. Janjic (Pharmacy: "Mindfulness: A Practice that Deepens Learning" February 22, 2012. Center for Teaching Excellence Workshop, Duquesne University
Service

University, School, or Department Service

Duquesne University
2011–Present Founder and Co-Director of Chronic Pain Research Consortium, Duquesne University
2016–Present Women in Science @Duquesne University, founding committee member
2018 Organizer of DOD Funding workshop for faculty, staff and students - cosponsored by CPRC and WIS of Duquesne University
2017 Hosted and organized the Exhibit Booth for Chronic Pain Research Consortium at the at American Pain Society Scientific Meeting, Pittsburgh, PA, May 2017
2017 Truth, Racial Healing and Transformation Center, led by Darlene Weaver - planning committee member (volunteered)
2016 Chair and facilitator for symposia and events of 2016 Chronic Pain Research Consortium Retreat - 5th Anniversary Celebration, Duquesne University
2016–18 Faculty advisor for Veterans Engagement Consortium
2017–Present Women in Science Mentoring subcommittee chair
2016, 2017 Day of Learning and Speaking Out (DLSO) held on March 22, 2016 - Organizing committee member
2012–15 Inspired Teaching Retreat with the Center for Teaching Excellence (Co-organizer, dialogue group leader, presenter)
2014–Present Member, dialogue participant and workshop panelist at the events of Spiritan Pedagogy movement led by Dr. Darlene Weaver
2012 CTE faculty workshop presenter and discussion leader
2011–15 Chronic Pain Research Consortium Research Retreats (Leading organizer)
School of Pharmacy and Graduate School of Pharmaceutical Sciences
2018 Pharmaceutics Discipline representative on the Seminar Series organizing committee
2016–18 Pharmaceutics Discipline faculty coordinator
2016–Present Faculty development committee
2016–17 Biomedical Sciences Journal Club (founding organizer, shared with Dr. Manickam)
2014–Present Committee for Faculty Development (Member, appointed by the Dean)
2010–16 Graduate Council (Member, appointed by the Dean)
2010–11 Division of Pharmaceutical Sciences Seminar Series Committee (Chair)
2012–Present Division of Pharmaceutical Sciences Seminar Series Committee (Discipline representative)
2013, 2015, 2017 AAPS Research Symposium poster and podium presentations Judge
2012, 2016 Oral Research Proposal Defense workshop for graduate students (leader and/or organizer)
2012 Medicinal Chemistry Faculty Search Committee (Member)
2011–12 ACPE Self-Study Faculty and Staff Subcommittee (Member)
2011–12 ACPE Self-Study Graduate Student Subcommittee (Member)
2011 Workgroup-Mentoring Program for Students, Faculty and Staff (Member)
2010 BMS PharmD Curricular Workgroup (Member)
2010–11 Original Research Proposal Defense Workshop for Graduate Students (Leader)
2010 Summer pharmaceutics research journal club (Organizer)
University of Pittsburgh
2001–05 Graduate Education and Research at the University of Pittsburgh (GEAR-UP) Program (Organizational Committee Member)
2003–04 Graduate Student Organization, School of Pharmacy (President)
2002 School of Pharmacy Dean Search Committee (Graduate Student Representative)
2002–03 Graduate Student Organization, School of Pharmacy (Vice-President)

Service Focused on Promoting Wellness and Wellbeing

2016–18 Mindful Mondays, ongoing practice workshop for scientists, students, faculty and staff started in the Fall 2016 (founder/facilitator).
2014–Present Student wellness mini-workshops in Living/Learning Centers
2013–14 Student Coping Skills Workgroup in School of Pharmacy (Co-chair)
2014 Wellness seminar on mindfulness and stress reduction in the pharmacy pre-professional program (co-developer and presenter)
2014–15 "Contemplative Scientist" weekly dialogue group for researchers (leader, founder)
2013–14 Mindfulness in daily life/learning discussion leader with RAs in Living/Learning Centers
2011–Present "Dr. J's De-Stressor" resource folder in blackboard sites in PharmD and graduate courses - live discussions on stress reduction in graduate school life
2011–12 "Skeptic's guide to stress reduction and meditation" presented at faculty meetings and to graduate students

Professional Service

2019 Guest Editor, Molecules, Special Issue "Targeted and Personalized Nanomedicines"
2019 Guest Co- Editor (with V.S. Gorantla, WFIRM, guest editor), Nanomedicine, Special focus issue on the topic 'Nanomedicine in Organ Transplantation and Regenerative Surgery - Advances, Applications, and Future Directions'
2019 External advisory board member, Cellular Approaches to Tissue Engineering and Regeneration (CATER) training program, University of Pittsburgh, Pittsburgh, PA
2018–19 Organizing committee member, McGowan Institute of Regenerative Medicine Scientific Retreat/ Session organizer/chair on 3 symposiums: Event held on March 11-12, 2019, UPITT University Club, Pittsburgh, PA

Peer Review for Grants

2019 NCI Innovative Research in Cancer Nanotechnology
2019 AAAS Reviews
2016, 2017, 2018 NIDA CEBRA R21 study section (Served 5 times)
2017 NIBIB CMIP Study section (ad hoc)
2016 NIH Special panel applications reviewer
2013–15 Grant reviewer for Prostate Cancer Foundation UK
2013 Grant reviewer for Polish Academy of Sciences
2011 Grant reviewer for Duquesne University Faculty Development Fund

Invited Peer Review for Scholarly Publications

2018–19 Reviewer for Nanoscale
2015–17 Reviewer for Molecular Pharmaceutics
2014 Reviewer for Food and Function
2014–16 Reviewer for Journal of American Chemical Society
2014 Reviewer for Nature Chemistry
2014 Reviewer for The Journal of Neuroscience
2014 Reviewer for ChemPhysChem
2014 Reviewer for Chemical Science
2014 Reviewer for PLOS One
2013, 2014 Reviewer for World Molecular Imaging Congress abstracts submissions
2013 Reviewer for Nanomedicine
2013 Reviewer for Small
2013, 2015 Reviewer for International Journal of Pharmaceutics
2013 Reviewer for Journal of Materials Chemistry
2012 Reviewer for ChemMedChem
2011–15 Reviewer for Advanced Functional Materials
2010 Reviewer for ACS Medicinal Chemistry Letters
2010–15 Reviewer for Journal of Pharmaceutical Innovation

Community Service

2016, 2017, 2018 Science and cultural mini workshops in Mt. Lebanon Extended Day Program
2015 Volunteering in select school events at Markham Elementary School
2014 Fundraising for Serbian Flood Relief (Raised monetary funds and goods)
2011–12 Walk for the Cure (Susan G Komen Breast Cancer Foundation)
(Raised funds for Pittsburgh affiliate of Susan G. Komen)
2010 Juvenile Diabetes Research Foundation Walk