The Administration Building, “Old Main,” the first building constructed on the Duquesne campus, was dedicated in 1885.  It houses the Executive Offices of the University, Office of Admissions, Registrar’s Office, Spiritan Campus Ministry, Business Offices, Financial Aid Office, Learning Skills Center, and the offices of Development and Alumni. Adjoining the building is The Chapel of the Holy Spirit, which offers daily Masses.

Assumption Hall was dedicated in 1954 as Duquesne's first residence hall. A four-story structure situated above the Assumption Commons, the building has a student capacity of over 250, and offers both single and double occupancy rooms. The Living Learning Center includes a front desk area equipped with security cameras and ID card readers. It is home to the Honors College, student and administrative offices as well as the main office of Residence Life.

The Bayer Learning Center is a modern classroom building with multimedia classrooms/laboratories, complete with internet and interactive student personal response systems.  The Bayer Learning Center houses. Academic Research Center for Pharmacy Care of the Mylan School of Pharmacy. 

Brottier Hall is an apartment complex with impressive views of the Downtown skyline. The Office of Residence Life partners with Capstone On-Campus Management in the operation of Brottier Hall. It houses approximately 650 students in fully equipped studio, one-bedroom and two-bedroom apartments. Brottier Hall is a 20-story apartment complex built in 1967, with 314 total units. There is a fitness center, indoor parking garage, and study lounge. The facility includes a front desk area equipped with security cameras and ID card readers. The Brottier Hall Housing agreement begins in August and runs for 11.5 months. Meal plans are not required. However, a meal plan option is available on a voluntary basis. Upper-class, graduate and law students are welcome to apply for an apartment with an August start date. University policy does not permit children to reside in the Living Learning Centers.

The Bushinski Building (1204 Fifth Avenue) houses the Department of Facilities Management.

Canevin Hall, the oldest classroom building on campus, was built in 1922 and completely renovated in 1968.  The building received major upgrades in 2008.   A four-story building, it houses the School of Education, the Reading Clinic, the Guidance and Counseling Center, and the UCEA Center for Social Justice.

College Hall, a six-story classroom and office building dedicated in 1970, is the seat of the McAnulty College and Graduate School of Liberal Arts, housing the majority of its departments and facilities. Special instructional facilities include public computer laboratories, communication, interactive media, mathematics and social science computer laboratories, the Writing Center, TV/DVD Studio, and lecture halls.

The Cooper Building (916 Fifth Avenue) houses additional offices for Computing & Technology Services, Purchasing, Facilities Management and the Office of Environmental Health and Safety.

Des Places Living-Learning Center, opened in Fall 2012. Located next to McCloskey Field, this 12-story building offers 1, 2 and 3 bedroom suites for approximately 400 upper-class resident students. Each suite includes its own bathroom facilities. The building also houses the indoor bicycle storage area for the campus community. Des Places LLC was constructed with a commitment to sustainability and is LEEDTM Gold certified.

The Duquesne Towers, a 17-story, double-tower residence for approximately 1,100 men and women featuring separate housing wings for fraternities, sororities and student groups of all academic classes, was dedicated in 1970. The facility features a full-size indoor swimming pool, the Spiritan Campus Ministry Center, student mail center, and the Hogan Dining Center. The Duquesne Towers is also home to a computer lab that is available 24 hours a day to all students. The facility includes a front desk area equipped with security cameras and ID card readers.

The Duquesne Union. Since its dedication in 1967, the Duquesne Union has served as the center of campus life and student activities. The Union is home to many student organization and departmental offices which include the Center for Career Development, the Center for Student Involvement, Commuter Affairs, Greek Life, Student Conduct, Office of Diversity and Inclusion, Office of International Programs, Health Services, Freshman Development and Special Services. This facility also includes the Center for Pharmacy Care, the Information Center, Parking and DU Card Services, Les Idees Art Gallery, four dining options, Computer Store, Barnes and Noble Connections, Starbucks, meeting rooms, and lounges. The Union also houses the NiteSpot, a popular gathering place for programing and recreation, with events happening every night of the week.

Fisher Hall houses the Rangos School of Health Sciences’ Departments of Health Management Systems and Speech-Language Pathology, including the Speech-Language-Hearing Clinic, the University Counseling and Wellbeing Center, Risk Management, Center for Teaching Excellence, faculty and staff offices, and teaching and research laboratories.

The Center for Environmental Research and Education (CERE) and the administrative offices of the Forensic Science and Law Program of the School of Science and Engineering are located on the 3rd floor of Fisher Hall.  The Department of Physics and the office of the Director of Student Services for the School of Science and Engineering are located on the 2nd and 3rd floors of Fisher Hall.

Fisher Hall also houses the Department of Theology, Department of Modern Languages and Literatures, computer labs, classrooms, and research laboratories. The School of Nursing is located on the fifth floor and includes administrative and faculty offices, a nursing computer laboratory, resource center, and lecture halls.

The Genesius Theater contributes significantly to the performing arts experience at Duquesne. Named after the patron saint of actors, musicians, and performers, the Genesius Theater is an academic building at Duquesne that hosts an intimate 120-seat Black Box Theater, a Rehearsal Hall, a Lobby and support areas. Together these facilities serve for the preparation and presentation of live theatrical, musical, and multi-media performances. These live performances foster learning experiences that manifest, demonstrate, and reinforce the lessons taught in the classroom. They also provide visibility of the performing arts at Duquesne to the wider community. The Genesius Theater is the home of the Duquesne University Red Masquers, the oldest, continually producing theater company in Pennsylvania; as well as other performing arts groups on campus.

The performing arts play a central role in the liberal arts experience for Duquesne students - contributing to their processes of acquiring knowledge, achieving academic and personal growth, teamwork, critical thinking, creative expression, and cultivating the qualities that prepare them to participate constructively in the life of the University and their communities. All live performances in the Genesius Theater contribute to the Catholic mission of the University and the Spiritan tradition of Education for the Mind, Heart, and Spirit, and cultural diversity.

Hanley Hall, dedicated in 1982 and named for Edward J. Hanley, houses School of Law offices, amphitheater lecture halls, seminar and classroom areas, moot courtrooms, research and study rooms, interview rooms, a coffee shop, student and faculty lounges, and offices for student organizations. Over the last decades, the School of Law completed substantial renovations and new construction at the facilities. The John E. Murray, Jr. Pavilion and extensive renovations to the Duquesne Kline Law Library, combined to increase the School of Law's space to approximately 125,000 square feet. The School of Law renovated Room 303 to create an auditorium with seating for more than 140, and a mock courtroom space. The building also houses the Bridget and Alfred Pelaez Legal Writing Center, home to the School of Law's nationally ranked Legal Research and Writing program. A full-service law career center operates daily. The entire building has been regularly upgraded with the latest technology.

The School of Law's Tribone Center for Clinical Legal Education, located at 914 Fifth Avenue, is within blocks of downtown Pittsburgh's courthouses, public agencies and law offices. The Tribone Center features multiple client meeting rooms, conference spaces, classrooms, and a moot courtroom equipped with state-of-the-art technology. Our clinical education program started in 1995, originally named for a donor, as the Hugo L. Black Law Clinic. In 2013, it was named in honor of Tom Tribone, Chief Executive Officer Franklin Park Investments, whose gift helped fund the clinic's move to Fifth Avenue.
Additional funding for the Center for Clinical Legal Education was recieved and the center was upgraded in 2015. This was provided in part through a $500,000 grant from the state's Redevelopment Assistance Capital Program and a $250,000 Community Infrastructure and Tourism Fund grant from the Redevelopment Authority of Allegheny County. The Tribone Center enjoys a unique location in a three-story building at 912-914 Fifth Avenue. It is easily accessible to clients and provides much-needed services to residents of Pittsburgh and the region.

Health Sciences Building, dedicated in 1991, resulted from the renovation of the old gymnasium.  The four-story building is the home of the John G. Rangos, Sr. School of Health Sciences with its departments of athletic training, occupational therapy, physical therapy, physician assistant studies and Ph.D. program in Rehabilitation Science.  The building provides faculty and staff offices and teaching and research laboratories.

Koren Building (718 Fifth Avenue) houses the offices of Human Resource Management, Student Health Insurance, Risk Management, and Office of Marketing and Communications.

Laval House houses the Spiritan Vocation Office.

Libermann Hall is a combination of academic and office space. The facility houses the Biomedical Engineering Program, Center for International Relations, Enrollment Management, Center for Catholic Faith and Culture, Center for Spiritan Studies, a teaching laboratory for the Rangos School of Health Sciences' Department of Occupational Therapy, and the Learning and Simulation Center for the School of Nursing.

Locust Garage Office houses Events and Conference Services.

McCloskey Field, dedicated in the mid-1970s, and renovated in 1998, is used by the Duquesne track and field teams. The 60-yard lighted field, located next to UPMC Cooper Fieldhouse, features an artificial turf surface surrounded by a four-lane all-weather track.

Richard King Mellon Hall of Science, a four-story structure dedicated in 1968 and an award-winning building designed by Mies van der Rohe, houses the Departments of Biological Sciences and Chemistry and Biochemistry, the Dean’s Office for the School of Science and Engineering, and faculty offices, classrooms and laboratories.  The fourth floor and the basement are occupied by the Academic Research Centers for Pharmaceutical Technology, for Pharmacy Practice, and for Pharmaceutical Information and by faculty and administrative offices and laboratories of the Mylan School of Pharmacy and the Graduate School of Pharmaceutical Sciences.   Instructional facilities include two large amphitheater-style lecture halls with seating capacities of 250 each and science computer facilities.

Mendel Hall, located on Forbes Avenue.

Murphy Building (20 Chatham Square) houses the Center for Community-Engaged Teaching and Research.

The Mary Pappert School of Music, dedicated in 1967, has 68 Steinway pianos, six organs and a substantial inventory of orchestral, band and electronic instruments available for student use. The building features acoustically treated classrooms, practice rooms and rehearsal spaces. The PNC Recital Hall is equipped with two Steinway model D concert grand pianos.  The newly renovated Dr. Thomas D. Pappert Center for Performance and Innovation provides an additional performance venue and includes a state-of-the art mastering suite designed for multi-channel audio production, audio for video and live webcasting. The Fender Electronic Studio, Recording Studio, Keyboard Lab, and Music Technology Center all feature up-to-date facilities and equipment for composing, performing and recording music.

The Power Center, a 130,000-square-foot multipurpose facility, was named for Duquesne’s first president and Spiritan priest, the Rev. William Patrick Power, C.S.Sp. It is a Green Building Alliance silver certified LEED building. The center is located at the corner of Chatham Square and Forbes Avenue, and includes Barnes & Noble at Duquesne; the Power Recreation Center; and two dining facilities—a full-service restaurant, The Red Ring Bar & Grille, and a Freshens fresh food studio. The top level of the building, which is the equivalent of eight stories, holds the Charles J. Dougherty Ballroom, featuring panoramas of the city, balconies and 7,500 square feet capable of accommodating up to 700 people. High-tech lighting, projection screens, a dance floor and portable stage are among the ballroom’s amenities. Soundproof panels allow the room to be configured to meet numerous needs, while the Fides Shepperson Suite provides a spacious pre-event area featuring four plasma screens. The penthouse level also features a full-service kitchen. Access is provided to the Forbes Parking Garage and campus via the Sklar Skywalk, the city’s highest pedestrian walkway.

The Power Recreation Center, an 80,000-square-foot-area comprising the second, third, mezzanine, and fourth floors of the Power Center, is open seven days a week during the academic year (not in the summer) for Duquesne students and employees. Features include: secure access, separate student and staff locker facilities, several fitness studios, and 60 cardio fitness machines with personal viewing screens, two multi-purpose courts, walking/running track, two free weight rooms, racquetball courts, and offices.

The Public Safety Building is headquarters for the University’s Public Safety Office.

Rockwell Hall, dedicated in 1958, is a 10-story structure which houses the A.J. Palumbo School of Business Administration and the John F. Donahue Graduate School of Business and whose skywalk connects downtown Pittsburgh with Duquesne’s campus.  Rockwell Hall also houses a student lounge/vending machine area, Carfang Commons, team suites, the School of Business Technology Center, Computing and Technology Services, Small Business Development Center, Psychology Clinic, Printing and Graphics Department, the Beard Institute, and the Mills Complex.

Arthur J. Rooney Athletic Field. Located high atop the Bluff in the center of the Duquesne University campus, Arthur J. Rooney Athletic Field, the home of DU football, soccer and lacrosse, is one of the most unique multi-purpose facilities in the nation. Bordered by Academic Walk on one side and Mellon Hall of Science and Keller Fieldhouse on either end, Rooney Field offers scenic views of downtown Pittsburgh, the Monongahela River and Pittsburgh's historic South Side.

Bolstered by a two-phase, $4 million renovation completed in 2011, the lighted, FieldTurf-covered facility celebrates its 27th full-season anniversary in 2020-21.

The completion of Rooney Field - named in honor of Duquesne University football letterman and founder of the Pittsburgh Steelers National Football League team, Art Rooney - in 1993 enabled the Dukes to play football on campus for the first time since 1929.

Foresight and planning turned a former staff and faculty parking lot into what is now the focus of the Duquesne campus. The initial space limitations caused Rooney Field to be one of the few in college athletics that run east-to-west. Workers had to cut down approximately six feet to finish the playing surface. The excavation created both excellent sight lines and the terrace effect that allowed for concrete bleachers on the Academic Walk side of the field and grassy knoll on the Bluff Street side of the field.

The first phase of renovation work, completed late in the summer of 2008, included the creation of permanent grandstand seating on Bluff Street - replacing temporary bleachers that had been installed for the previous 14 years. Permanent concession stands and restrooms were also added to the south side of the field in 2008. The Academic Walk sideline also gained additional seating.

Keller Fieldhouse, which was formally dedicated with a ribbon-cutting ceremony on August 6, 2011, made up the second stage of the renovation. The project, which began following the 2010 season, was funded by private donations and is named after Jerome C. Keller, E'65, H'91, who provided a lead gift for the facility.

In addition, two new scoreboards were installed during the summer of 2011 replacing ones that were part of the original construction of the field.

The 2014 season saw completion of new locker room facilities for men's and women's soccer as well as women's lacrosse.

In October 2015, the Department of Athletics dedicated the Leigh Bodden Atrium. The atrium, which serves as the main entrance to Keller Fieldhouse, was renovated thanks to the generosity of Bodden, a Duquesne alumnus who spent nine seasons playing in the National Football League.

The Rooney Field artificial playing surface was most recently replaced prior to the 2019 season and new lights were installed in the summer of 2020.

In addition to serving as home for the DU men's and women's soccer, football and lacrosse teams, numerous other activities are held on Rooney Field. Various camps, team practices and intramural activities keep the field in constant use.

St. Ann Living-Learning Center, dedicated in 1964, is a seven-floor coed residence hall which houses over 500 freshman students. The residence hall includes a front desk area equipped with security cameras and ID card readers. St. Ann's also features a recreational lounge.

St. Martin Living-Learning Center will be closed for renovations during the 2021-2022 academic year.

Trees pool, located just beyond the east end zone of Rooney Field, serves as the home of the two-time Atlantic 10 Champion Duquesne swimming & diving team. Part of Towers Living and Learning Center, the 25-yard pool features eight lanes as well as permanent bleacher seating.

Trinity Hall, dedicated in 1952, is the residence of the Spiritans who serve the University as administrators and teachers. The grounds of the hall include an attractive yard, chapel and grotto.

UPMC Cooper Fieldhouse is the primary facility for Duquesne Athletics and the competition venue for men's and women's basketball as well as volleyball. Located on the corner of Forbes Avenue and Magee Street (formerly the A.J. Palumbo Center), the UPMC Cooper Field house reopened in February of 2021 after the completion of a comprehensive renovation. The building is named in honor of Duquesne basketball legend Charles "Chuck" Cooper. Cooper captained the men's basketball team before going on to become the first African-American to be drafted into 1950. His barrier-breaking legacy was recognized in 2019 when he was inducted into the Naismith Memorial Basketball Hall of Fame.

The renovations to the UPMC Cooper Fieldhouse have created a consolidated, total performance center and "hub" for Duquesne student-athletes. In adition to the main arena, this multi-purpose facility houses all the athletic training, sports performance and academic support services including:

  • The Folino Sports Performance Center: an 8,000 sq/ft space that features state-of-the-art, custom training equipment to be utilized by all Duquene student-athletes as well as fueling station and nutrition bar.
  • The Joe and Kathy Guyaus Player Development Center: a practice facility that includes two regulation basketball courts and indoor training space for all athletics teams.
  • The Gilliand Center for Academic Success and PNC Leadership Academy: Housing offices, individual and group study spaces, this 1500 sq area places academics within the same building as the training facilities and provides a central, exclusive study location for student -athletes.
  • Athletic Training: An updated and expanded space with an adjacent a 1,000sq/ft medical sutie that includes a dedicated physical therapy space, chiropractic services and dedicated recovery area. The renovation also included the expansion of the Physicians Exam Room.

The UPMC Cooper Fieldhouse also contains administrative offices, locker room facilities and the Rowing team offices. Other renovation highlights include:

  • A moderized facade that engages the building as a major thoroughfare from the Bluff to the Uptown neighborhood
  • Wider, more accessible concourses with improved concessions areas
  • The MFA Wealth Financial Club Lounge with a full-service bar and game day eating space
  • Six Luxury Suites
  • Expanded and upgraded technology throughout the facility, including state-of-the-art video boards, concourse and club-level televisions, along with an upgraded sound system.
  • New ticket office and team shop
  • Renovated office space for coaches and athletics staff.

 Beyond service as the home for matriculation and graduation ceremonies, Duquesne's home arena has been the site of multiple external athletics events including the:

  • Atlantic 10 Volleyball Championship (four-time host)
  • 2019 Atlantic 10 Women's Basketball Championship
  • 2018 NCAA Division II and Division III Valleyball National Championships
  • Men's and Women's National Invitation Tournment games as well as numerous high school tournaments and playoff games have also been contested at DU's on-campus home.

Van Kaam Building (1308 Fifth Avenue) houses Army ROTC.

Vickroy Hall, an upper-class coed residence hall that opened in 1997 with a bed capacity of approximately 280 residents, is a facility with double and triple rooms and bathrooms shared by two rooms (4 or 5 people). The facility includes a front desk area equipped with security cameras and ID card readers. A Ground floor multi-purpose room is available for meetings, programs, building functions, and has an available kitchen for residents.

Willms Building (18 Chatham Square) houses the Office of Community Engagement.